Results 41 to 50 of about 303,551 (337)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Optical Correction of Keratoconus with a Scleral Gas-Permeable Lenses
Oftalʹmologiâ, 2019 The optical properties of the cornea are determined by its ability to refract and transmit light. Keratoconus changes cornea’s shape, the surface of the cornea becomes irregular, which leads to a violation of light refraction and the occurrence of ...
A. V. Myagkov +4 more
doaj +1 more source
RNA Crosslinking Methods [PDF]
, 2009 RNA-RNA crosslinking provides a rapid means of obtaining evidence for the proximity of functional groups in structurally complex RNAs and ribonucleoproteins. Such evidence can be used to provide a physical context for interpreting structural information from other biochemical and biophysical methods and for the design of further experiments.
Michael E, Harris, Eric L, Christian
openaire +2 more sources
Protein flexibility is key to cisplatin crosslinking in calmodulin [PDF]
, 2012 Chemical crosslinking in combination with Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) has significant potential for studying protein structures and proteinprotein interactions.
Jimenez-Roldan, J. Emilio +6 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Tough Materials Through Ionic Interactions
Frontiers in Chemistry, 2021 This article introduces butyl acrylate-based materials that are toughened with dynamic crosslinkers. These dynamic crosslinkers are salts where both the anion and cation polymerize.
Linda Salminen +3 more
doaj +1 more source
Ultraviolet Corneal Crosslinking
Annals of the Russian academy of medical sciences, 2016 This review presents basic information on UV corneal crosslinking. The method is widely used in ophthalmology to treat various types of ectasia, which are characterized by progressive degenerative changes in the cornea, associated with its thinning , hazing and scarring, which leads to a significant reduction in visual acuity.
M M, Bikbov, A R, Khalimov, E L, Usubov
openaire +3 more sources
Gating mechanism of elongating β-ketoacyl-ACP synthases. [PDF]
, 2020 Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative ...
Bartholow, Thomas G +9 more
core
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
UV cross-linked polyvinylpyrrolidone electrospun fibres as antibacterial surfaces
Science and Technology of Advanced Materials, 2019 Many bacteria become progressively more resistant to antibiotics and it remains a challenging task to control their overall levels. Polymers combined with active biomolecules come to the forefront for the design of antibacterial materials that can ...
Barbara M. Maciejewska +9 more
doaj +1 more source