Results 1 to 10 of about 3,099 (216)

Antineoplastic properties and pharmacological applications of Crotalus durissus terrificus snake venom [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Snake toxins are widely studied owing to their importance in snakebite accidents, a serious public health issue in tropical countries, and their broad therapeutic potential.
Brunna Fernanda Arraez Alves, Rui Seabra Ferreira Jr   +1 more
doaj   +6 more sources

Fast venomic analysis of Crotalus durissus terrificus from northeastern Argentina [PDF]

Toxicon: X, 2020
The complete knowledge of the toxins that make up venoms is the base for the treatment of snake accidents victims and the selection of specimens for the preparation of venom pools for antivenom production. In this work, we used a fast and direct venomics
Luciano S. Fusco, Emidio B. Neto, Aleff F. Francisco, Jorge Alfonso, Andreimar Soares, Daniel C. Pimenta, Laura C. Leiva   +6 more
doaj   +8 more sources

Crotalus durissus terrificus crotapotin naturally displays preferred positions for amino acid substitutions [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin.
Laudicéia Alves de Oliveira, Rui Seabra Ferreira, Benedito Barraviera, Francilene Capel Tavares de Carvalho, Luciana Curtolo de Barros, Lucilene Delazari dos Santos, Daniel Carvalho Pimenta   +6 more
doaj   +10 more sources

Molecular interaction assays <i>in silico</i> of crotapotin from <i>Crotalus durissus terrificus</i> against the molecular target trypanothione reductase from <i>Leishmania braziliensis</i>. [PDF]

J Venom Anim Toxins Incl Trop Dis
Background: Leishmaniasis is a neglected disease that mainly affects impoverished populations and receives limited attention from governments and research institutions. Current treatments are based on antimonial therapies, which present high toxicity and
Macedo JM, Souza MF, Lima AM, Francisco AF, Kayano AM, Gusmão MEML, de Araújo ECS, Salvador GHM, Fontes MRM, Zuliani JP, Soares AM.   +10 more
europepmc   +4 more sources

In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu [PDF]

Pharmaceuticals, 2023
Quercetin derivatives have already shown their anti-inflammatory potential, inhibiting essential enzymes involved in this process. Among diverse pro-inflammatory toxins from snake venoms, phospholipase A2 is one of the most abundant in some species, such
Mariana Novo Belchor, Caroline Ramos da Cruz Costa, Airam Roggero, Laila L. F. Moraes, Ricardo Samelo, Isabelly Annunciato, Marcos Antonio de Oliveira, Sergio F. Sousa, Marcos Hikari Toyama   +8 more
doaj   +3 more sources

Local and systemic effects caused by Crotalus durissus terrificus, Crotalus durissus collilineatus, and Crotalus durissus cascavella snake venoms in swiss mice [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: Crotalus envenomations cause serious complications and can be fatal without appropriate treatment. Venom isoforms present and inter/intraspecific variations in the venom composition can result in different symptoms presented by bites by ...
Letícia Helena de Carvalho, Leda Fabiélen Teixeira, Kayena Delaix Zaqueo, Jéssica Felix Bastos, Neriane Monteiro Nery, Sulamita Silva Setúbal, Adriana Silva Pontes, Diana Butzke, Walter Cavalcante, Marcia Gallacci, Carla Freire Celedônio Fernandes, Rodrigo Guerino Stabeli, Andreimar Martins Soares, Juliana Pavan Zuliani   +13 more
doaj   +7 more sources

Bioaffinity Fishing Procedure Using Secretory Phospholipase A2 for Screening for Bioactive Components: Modulation of Pharmacological Effect Induced by sPLA2 from Crotalus durissus terrificus by Hispidulin from Moquiniastrum floribundum [PDF]

Molecules, 2020
Bioaffinity capturing of molecules allows the discovery of bioactive compounds and decreases the need for various stages in the natural compound isolation process.
Adeilso Bispo dos Santos Junior, Cinthia I. Tamayose, Marcelo J. P. Ferreira, Mariana N. Belchor, Caroline R. C. Costa, Marcos Antonio de Oliveira, Marcos Hikari Toyama   +6 more
doaj   +3 more sources

Crotalus durissus terrificus snake venom activates 3T3-L1 preadipocytes to release PGE₂, which depends on COX-2 expression and is modulated by PGE₂ EP2 receptor. [PDF]

Arch Toxicol
Snakebites are a worldwide public health problem with high-cost treatment in many countries. Crotalus genus snakes, commonly known as rattlesnakes, cause the most lethal snakebites in Brazil.
Teixeira DS, Maia-Marques R, Teixeira C.
europepmc   +4 more sources

Comparison of wildlife and captivity rattlesnakes (Crotalus durissus terrificus) microbiota Comparação da microbiota de cascavéis (Crotalus durissus terrificus) de vida-livre e cativeiro [PDF]

Pesquisa Veterinária Brasileira, 2009
The study evaluated and compared the aerobic microbiota from the oral cavity, cloaca and venom of Crotalus durissus terrificus snakes, recently caught from the wild and kept under quarantine (WQ), individual captivity (IC) and collective captivity (CC ...
Rui S. Ferreira Junior, Amanda K. Siqueira, Michelle V. Campagner, Tatiana Salerno, Taíssa C.S. Soares, Simone B. Lucheis, Antonio C. Paes, Benedito Barraviera   +7 more
doaj   +8 more sources

Crotoxin from Crotalus durissus terrificus is able to down-modulate the acute intestinal inflammation in mice. [PDF]

PLoS One, 2015
Inflammatory bowel diseases (IBD) is the result of dysregulation of mucosal innate and adaptive immune responses. Factors such as genetic, microbial and environmental are involved in the development of these disorders.
Almeida Cde S, Andrade-Oliveira V, Câmara NO, Jacysyn JF, Faquim-Mauro EL.   +4 more
europepmc   +4 more sources