Results 131 to 140 of about 1,216 (181)

Venom-derived peptides for breaking through the glass ceiling of drug development. [PDF]

Front Chem
Freuville L, Matthys C, Quinton L, Gillet JP.   +3 more
europepmc   +1 more source

Snake venom bioprospecting as an approach to finding potential anti-glioblastoma molecules. [PDF]

J Venom Anim Toxins Incl Trop Dis
Orozco-Mera J, Montoya-Gómez A, Lopes DS, Jiménez-Charris E.   +3 more
europepmc   +1 more source

Mechanistic insights from experimental autoimmune encephalomyelitis into immune regulation, autophagy, gut microbiota, blood-brain barrier integrity, and NLRP3 inflammasome-mediated pyroptosis in multiple sclerosis: potential clinical implications. [PDF]

Front Neurosci
Zhang SM, Tang WC, Liu FF, Bai QQ, Guo Y, Bai XZ, Wang YF, Ma XY, Pan SJ, Yang YH, Du GQ, Fan H.   +11 more
europepmc   +1 more source

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Synergism of the two subunits of crotoxin

Toxicon, 1982
Crotoxin, a potent neurotoxin from the venom of Crotalus durissus terrificus, is composed of an acidic subunit which is non-toxic and enzymatically inactive and a basic subunit which possesses a phospholipase activity and low toxicity. It is shown that crotoxin very efficiently blocks the cholinergic post-synaptic response of the isolated electroplaque
C Bon
exaly   +3 more sources

Crotoxin induces aggregation of human washed platelets

Toxicon, 1994
Crotoxin, the main toxic component isolated from the venom of the South American rattlesnake Crotalus durissus terrificus, is a reversible protein complex composed of a non-toxic non-enzymatic acidic polypeptide (crotapotin) and a toxic basic phospholipase A2 (PLA2).
E C, Landucci, A, Condino-Neto, A C, Perez, S, Hyslop, A P, Corrado, J C, Novello, S, Marangoni, B, Oliveira, E, Antunes, G, de Nucci   +9 more
openaire   +3 more sources

Influence of temperature upon effects of crotoxin and gamma-irradiated crotoxin at rat neuromuscular transmission

Toxicology Letters, 2000
The influence of temperature upon the effects of crotoxin (CTX), from Crotalus durissus terrificus venom, and gamma-irradiated (60Co, 2000 Gy) crotoxin (iCTX) was studied in rat neuromuscular transmission 'in vitro'. Indirect twitches were evoked in the phrenic-diaphragm preparation by supramaximal strength pulses with a duration of 0.5 ms and ...
Gallacci, M., Nascimento, N., Rogero, JR, Vassilieff, V. S.   +3 more
openaire   +4 more sources

Cytotoxicity of crotoxin on murine erythroleukemia cellsin vitro

Investigational New Drugs, 1993
The cytotoxic effect of crotoxin, a heterodimeric phospholipase A2 from the venom of Crotalus durissus terrificus, was examined on murine erythroleukemia cells in vitro. Crotoxin cytocidal effect on cell growth had an EC50 of approximately 0.1-0.2 microM (3.0-5.0 micrograms/ml) in serum-free medium.
Juan C Vidal, Robert E Corin, J C Vidal
exaly   +3 more sources

Crotoxin acceptor protein isolated from Torpedo electric organ: binding properties to crotoxin by surface plasmon resonance

Toxicon, 2003
Crotoxin, a potent neurotoxin from the South American rattlesnake Crotalus durissus terrificus, is a heterodimeric phospholipase A(2) (EC 3.1.1.4), which blocks the release of acetylcholine from peripheral neurons. We previously have suggested the existence of a 48 kDa crotoxin-binding protein in the presynaptic membranes of the electric organ of ...
Grazyna Fauré, Alenka Ćopić, Igor Krizaj   +2 more
exaly   +3 more sources

Biochemistry and pharmacology of the crotoxin complex

Naunyn-Schmiedeberg's Archives of Pharmacology, 1971
H Breithaupt
exaly   +3 more sources

The mechanism of inhibition of phospholipase activity of crotoxin B by crotoxin A

Toxicon, 1983
In the crotoxin complex isolated from Crotalus durissus terrificus venom, the component A inhibits the phospholipase A2 activity of crotoxin B only when the substrate is in the aggregated form, preventing the interaction of the enzyme with lecithin--water interfaces.
G, Canziani, C, Seki, J C, Vidal
openaire   +2 more sources