Results 111 to 120 of about 14,674 (226)
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Stomach cancer (SC) or gastric cancer (GC) is one of the most common gastrointestinal malignancies. Currently, some studies based on competing endogenous RNAs (ceRNA) network analysis have been assessed for this cancer. The construction and analysis of ceRNA network is a novel approach for identification of RNA‐based biomarkers in cancer ...
Habib MotieGhader +2 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Clustered regularly interspaced short palindromic repeat (CRISPR) is transforming Huntington's disease research through allele‐selective huntingtin (HTT) targeting, transcriptional and RNA suppression, and advanced disease modelling. Progress towards precision therapy depends on safe central nervous system (CNS) delivery, reduced off‐target and immune ...
Kairat Zhakipbekov +11 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.This review summarises the detection methods for severe fever with thrombocytopenia syndrome virus based on CRISPR platforms. (A) CRISPR with fluorescent reporter. (B) CRISPR with lateral flow test strip. (C) CRISPR with DNAzyme. (D) Digital CRISPR. (E) CRISPR with single micro‐ring resonator biosensor. (F) self‐amplifying signal amplification strategy
Junhu Wang +8 more
wiley +1 more source
, 2020 Current CRISPR-Cas-based nucleic acid sensing methods relying on the preassembled Cas-crRNA complexes are generally limited to the detection of protospacer-adjacent motif (PAM)-containing sequences, and nonspecific backgrounds are inevitable.
Wei Ren (267391) +4 more
core +1 more source
Hot and crispy : CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus [PDF]
, 2013 The CRISPR (clustered regularly interspaced short palindromic repeats) and Cas (CRISPR-associated) genes are widely spread in bacteria and archaea, representing an intracellular defence system against invading viruses and plasmids.
Zhang, Jing, White, Malcolm F.
core +1 more source
Plag1 Regulates Sensorimotor Modulation in Zebrafish
International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.PLAG1 regulates early neurobehavioural development in zebrafish. Reducing plag1 alters craniofacial patterning, increases thigmotaxis and changes responses to light and acoustic stimuli, while gross brain structure and motor neuron development remain largely intact.
Jemma G. Gasperoni +5 more
wiley +1 more source
Communications BiologyThe CRISPR system finds extensive application in molecular biology, but its continuous activity can yield adverse effects. Leveraging programmable CRISPR/Cas9 function via nano-device mediation effectively mitigates these drawbacks.
Mohammad Hashemabadi +5 more
doaj +1 more source
MicrobiologyOpen, Volume 15, Issue 5, October 2026.This graphical abstract illustrates a rapid diagnostic platform for Mycoplasma bovis detection using Recombinase Polymerase Amplification coupled with CRISPR–Cas12a targeting the uvrC gene. The assay operates at 37°C–39°C, delivers results within 1 h, and demonstrates complete concordance with PCR in cattle and bison clinical samples.
Diba Yaghoubi, Viju V. Pillai
wiley +1 more source
High-accuracy crRNA array assembly strategy for multiplex CRISPR
Molecular Therapy Nucleic AcidsSimultaneous targeting of multiple loci with the CRISPR system, a tool known as multiplex CRISPR, offers greater feasibility for manipulating and elucidating the intricate and redundant endogenous networks underlying complex cellular functions. Owing to the versatility of continuously emerging Cas nucleases and the use of CRISPR arrays, multiplex ...
Xiangtong Zhao +11 more
openaire +3 more sources