Results 101 to 110 of about 132,225 (219)

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

Thermomechanics of Picoliter Liquids Encapsulated in Metal Microarchitectures

Advanced Materials, EarlyView.
Picoliter‐scale water is encapsulated inside hollow copper microcylinders through a single‐step localized electrodeposition process. Mechanical testing at room and cryogenic temperatures reveals that incompressible liquid and load‐bearing microscale ice enhance the strength and deformation behavior of the composite structure.
Sung‐Gyu Kang, Kyeongjae Jeong, Bárbara Bellón, Lalith Kumar Bhaskar, Leonardo Shoji Aota, Jeongin Paeng, Dipali Sonawane, Kuan Ding, Se‐Ho Kim, Allison Goetz, Benjamin Apeleo Zubiri, Erdmann Spiecker, Ayman El‐Zoka, Baptiste Gault, Gerhard Dehm, Rajaprakash Ramachandramoorthy   +15 more
wiley   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Two‐Photon 3D Printing of Functional Microstructures Inside Living Cells

Advanced Materials, EarlyView.
This study demonstrates 3D printing inside living cells by using two‐photon photo‐lithography. A bio‐compatible photoresist is injected into cells and selectively polymerized with a femtosecond laser, creating custom‐shaped intracellular structures with submicron resolution.
Maruša Mur, Aljaž Kavčič, Uroš Jagodič, Rok Podlipec, Matjaž Humar   +4 more
wiley   +1 more source

Progress towards revealing the mechanism of herpesvirus capsid maturation and genome packaging

Protein & Cell, 2020
Zhihai Li, Xuekui Yu
doaj   +1 more source

Hydrogelation via Supramolecular Copolymerization of Structural Water within Adaptive Metal–Organic Fibers

Advanced Materials, EarlyView.
Structural water is harnessed as an active co‐monomer to drive supramolecular polymerization in bulk water. Zinc(II) Salphen complexes confine water molecules to form hollow, metal–organic nanofibers that assemble into adaptive hydrogels with thermoresponsive mechanics and selective chiral recognition.
Merlin R. Stühler, Hesam Makki, Tarek Hilal, Debsena Chakraboty, Mathias Dimde, Kai Ludwig, Rainer Haag, Sabine Rosenfeldt, Dorothee Silbernagl, Andreas Schäfer, Alex J. Plajer   +10 more
wiley   +1 more source

C: Cryo-Electron Microscopy of Membrane Contact Sites and Their Components

Contact
Electron microscopy has played a pivotal role in elucidating the ultrastructure of membrane contact sites between cellular organelles. The advent of cryo-electron microscopy has ushered in the ability to determine atomic models of constituent proteins or
Cyan Ching, Julien Maufront, Aurélie di Cicco, Daniel Lévy, Manuela Dezi   +4 more
doaj   +1 more source

Positively Charged Polymer‐Brush MOFs for Large‐Area, Pressure‐Resistant Gas Separation Membranes

Advanced Materials, EarlyView.
A universal POPA strategy enables positively charged polymer‐brush MOFs with self‐adaptive interfacial interlocking to resist aggregation under fast processing. This design ensures seamless dispersion within large‐area selective layers, achieving 1 m‐wide roll‐to‐roll fabrication of pressure‐resistant MMCMs with tunable CO2 separation performance ...
Yi Yang, Ye Yuan, Yuxiu Sun, Fei Shi, Chenyang Song, Weifan Wang, Qinghua Li, Menglong Sheng, Zhihua Qiao, Jingwei Hou, Anthony K. Cheetham, Zhi Wang   +11 more
wiley   +1 more source

Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings

Advanced Materials, EarlyView.
Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed, Yu‐Hsuan Peng, Azra Atabay, Krishna Gupta, Toni Müller, Carolin Fischer, Ilka M. Hermes, Jens‐Uwe Sommer, Michael Lang, Elisha Krieg   +9 more
wiley   +1 more source