Results 171 to 180 of about 2,441,948 (283)

Optimized tissue sample preparation for cryo-electron tomography using serial lift-out. [PDF]

Biophys Rep
Du W, Yang J, Guo Q.
europepmc   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

A variational framework with composite sparse regularization for cryo-electron tomography reconstruction. [PDF]

Bioinformatics
Yu C, Xu Z, Zeng Q, Wan X, El-Messiry H, Zhang F, Han R.   +6 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

CeO2‐Based Electrocatalysts for the Oxygen Evolution Reaction: Design, Dynamic Mechanisms, and Electrolyte Adaptability

Advanced Science, EarlyView.
This Review shows how cerium oxide helps water‐splitting catalysts work better and last longer. It explains how CeO2 tunes electronic structure, oxygen‐vacancy behavior, and surface reconstruction, while adapting to alkaline, acidic, and seawater conditions.
Zhen Cui, Ailing Song, Zirui Cui, Manman Duanmu, Zhipeng Ma, Hao Liu, Guangjie Shao, Xinyi Tan, Guoxiu Wang, Hao Tian   +9 more
wiley   +1 more source

Applications and prospects of cryo-electron tomography in drug discovery and understanding disease. [PDF]

Curr Opin Struct Biol
Clemente CM, Mobarec JC, Bharat TAM.
europepmc   +1 more source

A Fluorogenic Cysteine‐Tetrapeptide Tagging Strategy for Nonperturbative Protein Labeling and Protein–Ligand Interaction Tracking

Advanced Science, EarlyView.
A compact Phe‐Cys‐Pro‐Phe (FCPF) tag and an environment‐sensitive SBD‐Cl‐derived probe form a sequence‐selective fluorogenic pair for wash‐free live‐cell protein imaging. This minimally perturbing chemistry allows flexible insertion at termini or loops, produces strong fluorescence upon local microenvironment confinement, supports FRET‐assisted ...
Xiao Wang, Xingcan Pan, Yongling Ying, Ziqian Bai, Jingming Zhang, Zhuang Shao, Jialiang Qian, Hongwei Li, Ning Zhang, Fan Yang, Yuan Liu, Xing Yang   +11 more
wiley   +1 more source

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

In situ architecture of plasmodesmata in Physcomitrium patens resolved by cryo-electron tomography. [PDF]

Nat Plants
Dickmanns M, Pöge M, Xu P, Gombos S, Barr ZK, Miras M, Plitzko JM, Simon R, Schulze WX, Frommer WB, Baumeister W.   +10 more
europepmc   +1 more source

Phosphonium Ionic Liquids for Electrochemical Energy Storage: Structure–Property–Interphase Relationships and Design Rule

Advanced Science, EarlyView.
Phosphonium ionic liquids offer a versatile platform for safer and more durable energy storage. This Review connects cation–anion structure with solvation, ion transport, electrochemical stability, and interphase formation across diverse battery chemistries.
Amir Haghipour, Ishanka Thennakoon, Aishwaryaba Jadeja, Daniel Rauber, Markus Gallei, Rolf Hempelmann, Sangwon Kim, Jungtae Kim   +7 more
wiley   +1 more source