Results 161 to 170 of about 48,476 (320)
Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing
Advanced Science, Volume 13, Issue 3, 14 January 2026.Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley +1 more source
Aβ antibodies target not only amyloid plaques but also distinct brain cells and vessels
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract BACKGROUND Amyloid beta (Aβ) antibodies are the only therapies to slow cognitive decline in Alzheimer's disease (AD). Yet the sites where antibodies engage Aβ in the brain and mechanisms that lower Aβ are not fully understood. Defining Aβ antibody localizations in the brain is essential to understand how immunotherapy is beneficial for AD ...
Gehua Wen +6 more
wiley +1 more source
Cryoprotectant kinetic analysis of a human articular cartilage vitrification protocol
, 2016 Nadia Shardt +5 more
openalex +1 more source
AAV‐PHP.eB Peripheral Delivery and Central Expression in Cre Mice
Journal of Comparative Neurology, Volume 534, Issue 1, January 2026.Retro‐orbital injection of AAV‐PHP.eB‐FLEX‐tdTomato into four different strains of Cre mice produced various and distinct patterns of transduction efficiency and tropism across brain regions and cell types. We found many target neurons expressing tdTomato in most but not all strains, along with a low level of nonspecific (Cre‐independent) expression ...
Haidong Zhu, Joel C. Geerling
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Pitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Yan Zhao +13 more
wiley +1 more source
Freezing without cryoprotectant [PDF]
Acta Crystallographica Section A Foundations and Advances, 2016 Yvonne Thielmann +4 more
openaire +1 more source
Health Science Reports, Volume 9, Issue 1, January 2026.ABSTRACT Background and Aims The escalation of chronic wounds necessitates advanced therapeutic strategies beyond current interventions. Hydrogel dressings, particularly injectable hydrogels, offer promising solutions due to their water absorption capacity, structural resilience, and ease of application.
Mohammad Ebrahim Astaneh +5 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.Maternal supplementation with a synbiotic nutraceutical consisting of jabuticaba peel and Limosilactobacillus fermentum strains during gestational diabetes mellitus (GDM) induces targeted shifts in gut microbial structure and attenuates systemic inflammatory signaling.
Deborah Emanuelle de Albuquerque Lemos +8 more
wiley +1 more source