Design and Characterization of Model Systems that Promote and Disrupt Transparency of Vertebrate Crystallins In Vitro [PDF]
Advanced Science, 2023 Positioned within the eye, the lens supports vision by transmitting and focusing light onto the retina. As an adaptive glassy material, the lens is constituted primarily by densely‐packed, polydisperse crystallin proteins that organize to resist ...
Michael R. Bergman +4 more
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The human crystallin gene families [PDF]
Human Genomics, 2012 Crystallins are the abundant, long-lived proteins of the eye lens. The major human crystallins belong to two different superfamilies: the small heat-shock proteins (α-crystallins) and the βγ-crystallins.
Wistow Graeme
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Zebrafish as a model for crystallin-associated congenital cataracts in humans [PDF]
Frontiers in Cell and Developmental BiologyCongenital cataracts are a leading cause of vision loss in children and can be an isolated finding or associated with systemic abnormalities. Isolated congenital cataracts are most commonly associated with pathogenic variants in one of the Crystallin ...
Jennifer L. Rossen +5 more
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Characterization of the Interaction of Human γS Crystallin with Metal Ions and Its Effect on Protein Aggregation [PDF]
BiomoleculesCataracts are diseases characterized by the opacity of the ocular lens and the subsequent deterioration of vision. Metal ions are one of the factors that have been reported to induce crystallin aggregation.
Reinier Cardenas +3 more
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The Functional Significance of High Cysteine Content in Eye Lens γ-Crystallins [PDF]
BiomoleculesCataract disease is strongly associated with progressively accumulating oxidative damage to the extremely long-lived crystallin proteins of the lens. Cysteine oxidation affects crystallin folding, interactions, and light-scattering aggregation especially
Eugene Serebryany +2 more
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The Effect of Attractive Interactions and Macromolecular Crowding on Crystallins Association. [PDF]
PLoS ONE, 2016 In living systems proteins are typically found in crowded environments where their effective interactions strongly depend on the surrounding medium. Yet, their association and dissociation needs to be robustly controlled in order to enable biological ...
Jiachen Wei +3 more
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G91-deletion in βA3/A1-crystallin induces cellular and molecular changes in mouse lenses leading to congenital cataract development. [PDF]
PLoS ONECRYβA1-ΔG91 (βA3ΔG91) is a mutational hotspot in CRYβA1, which causes autosomal dominant congenital nuclear cataract in humans and mice. Previous in-vitro studies of recombinant βA3ΔG91 showed defective folding, decreased solubility, and aberrant ...
Akosua K Boateng +2 more
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In silico identification of the anticataract target of βB2-crystallin from Phaseolus vulgaris: a new insight into cataract treatment [PDF]
Frontiers in ChemistryIntroductionSevere protein clumping in the lens can block light and lead to vision issues in cataract patients. Recent studies have linked β-crystallins, which are key proteins in the lens, to the development of cataracts.
Sunday Amos Onikanni +17 more
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In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallin. [PDF]
PLoS ONE, 2014 αA-crystallin and αB-crystallin are members of the small heat shock protein family and function as molecular chaperones and major lens structural proteins.
Usha P Andley +2 more
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Mollusc Crystallins: Physical and Chemical Properties and Phylogenetic Analysis
Diversity, 2022 The purpose of the present study was to perform bioinformatic analysis of crystallin diversity in aquatic molluscs based on the sequences in the NCBI Protein database.
Irina N. Dominova, Valery V. Zhukov
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