Results 91 to 100 of about 8,769 (230)
Protein Science, Volume 35, Issue 4, April 2026.Abstract TAR DNA‐binding protein 43 (TDP‐43) is a nucleic acid‐binding protein that regulates processes of mRNA metabolism, during which it undergoes condensation mediated by its C‐terminal low‐complexity domain (TDP‐43LCD). TDP‐43 aggregation and condensation are associated with neurodegenerative disease.
Thomas B. Walker +7 more
wiley +1 more source
Development of cataract caused by diabetes mellitus: Raman study [PDF]
, 2004 Diabetes mellitus succeeded by diabetic cataract was induced to experimental animals (Wistar rats) by applying an Alloxan injection. Eye properties deterioration were monitored from clinical standpoint and using Raman and infrared spectroscopies.
Furić, Krešimir +2 more
core +1 more source
Catalytic Amyloids: Turning Fibrils Into Biocatalysts
Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito +3 more
wiley +1 more source
Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. [PDF]
, 2014 The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens.
Anastas, Sara +9 more
core +3 more sources
A 17‐year‐old male with chronic epilepsy status post remote functional hemispherectomy
Brain Pathology, EarlyView.
Claire Voyles +3 more
wiley +1 more source
c‐MAF Transcriptionally Activates Slc40a1 to Repress Ferroptosis in Sepsis‐Associated Encephalopathy
CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.c‐MAF and its downstream target Slc40a1 were identified as key regulators of ferroptosis in septic mouse hippocampi. Neuron‐specific knockdown of either gene aggravated CLP‐induced cognitive deficits and ferroptosis, whereas their overexpression exerted protective effects.
Wenqin Song +5 more
wiley +1 more source
UV-radiation Induced Disruption of Dry-Cavities in Human γD-crystallin Results in Decreased Stability and Faster Unfolding [PDF]
, 2012 Age-onset cataracts are believed to be expedited by the accumulation of UV-damaged human γD-crystallins in the eye lens. Here we show with molecular dynamics simulations that the stability of γD-crystallin is greatly reduced by the conversion of ...
Huynh, Tien +4 more
core +2 more sources
Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT The vital cofactors NADH and NADPH are prone to hydration, forming hydroxylated redox‐inactive derivatives (NADHX and NADPHX) in cells. These damaged metabolites are repaired by two highly conserved enzymes, an NAD(P)HX dehydratase (NAXD) and an NAD(P)HX epimerase (NAXE).
Myrto Patraskaki +6 more
wiley +1 more source
Mass Spectrometry Reviews, Volume 45, Issue 2, Page 218-230, March/April 2026.ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley +1 more source