Post-translationally modified human lens crystallin fragments show aggregation in vitro
Biochemistry and Biophysics Reports, 2017 Background: Crystallin fragments are known to aggregate and cross-link that lead to cataract development. This study has been focused on determination of post-translational modifications (PTMs) of human lens crystallin fragments, and their aggregation ...
O.P. Srivastava +3 more
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Significance of interactions of low molecular weight crystallin fragments in lens aging and cataract formation [PDF]
, 2008 Analysis of aged and cataract lenses shows the presence of increased amounts of crystallin fragments in the high molecular weight aggregates of water-soluble and water-insoluble fractions.
Murugesan, Raju +3 more
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Protein refractive index increment is determined by conformation as well as composition. [PDF]
, 2018 The refractive index gradient of the eye lens is controlled by the concentration and distribution of its component crystallin proteins, which are highly enriched in polarizable amino acids.
Bierma, Jan C +4 more
core
Cataract-associated P23T γ 3D-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH [PDF]
, 2017 Cataracts cause vision loss through the large-scale aggregation of eye lens proteins as a result of ageing or congenital mutations. The development of new treatments is hindered by uncertainty about the nature of the aggregates and their mechanism of ...
Boatz, JC +4 more
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Elucidating the mechanism of anti-apoptotic activity of α-crystallin and its therapeutic potential [PDF]
Journal of Stress Physiology & Biochemistryα- Crystallins are the structural proteins of the eye lens which possess anti-apoptotic activity. Both αA- and αB- crystallins are distinct antiapoptotic regulators which can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family in order
Aparajita Chakraborty +2 more
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Crystallin αB acts as a molecular guard in mouse decidualization: Regulation and function during early pregnancy [PDF]
, 2014 Ru-Juan Zuo +5 more
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Studia Universitatis Babes-Bolyai ChemiaCataract, the leading cause of blindness worldwide, is characterized by the presence of a cloudy area in the eye lens resulting in a loss of transparency.
Călin G. FLOARE +3 more
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A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues
Redox Biology, 2015 Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration, the
Sarah A. Hibbert +7 more
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Influence of Thermal Perturbation of the Oligomeric Size of -Crystallin on its Chaperone Function – A Biophysical Study [PDF]
, 2010 -Crystallin is the major protein component of the vertebrate eye lens and is composed of two subunits A- and B-, 20 kDa each having 57% sequence homology between them. Both subunits associate to form large oligomer of 800 kDa average molecular weight. It
Laha, B
core
Lens Crystallins of Invertebrates [PDF]
, 1996 Stanislav I. Tomarev, Joram Piatigorsky
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