Results 11 to 20 of about 15,579 (272)

Zinc and Copper Ions Induce Aggregation of Human β-Crystallins

Molecules, 2022
Cataracts are defined as the clouding of the lens due to the formation of insoluble protein aggregates. Metal ions exposure has been recognized as a risk factor in the cataract formation process. The γ and β crystallins are members of a larger family and
Vanesa Ramirez-Bello, Javier Martinez-Seoane, Arline Fernández-Silva, Carlos Amero   +3 more
doaj   +1 more source

Protective Effects of Acetylation on the Pathological Reactions of the Lens Crystallins with Homocysteine Thiolactone. [PDF]

PLoS ONE, 2016
Various post-translational lens crystallins modifications result in structural and functional insults, contributing to the development of lens opacity and cataract disorders.
Zeinab Moafian, Kazem Khoshaman, Ahmad Oryan, Boris I Kurganov, Reza Yousefi   +4 more
doaj   +1 more source

Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis. [PDF]

PLoS ONE, 2013
α-Crystallins, initially described as the major structural proteins of the lens, belong to the small heat shock protein family. Apart from their function as chaperones, α-crystallins are involved in the regulation of intracellular apoptotic signals.
Séverine Hamann, Sylviane Métrailler, Daniel F Schorderet, Sandra Cottet   +3 more
doaj   +1 more source

Investigating the Role of Zebrafish Retinoschisin Homologs Rs1a and Rs1b During Retinal Development. [PDF]

Dev Neurobiol
ABSTRACT Deficiency in the retinoschisin protein (RS1) causes X‐linked juvenile retinoschisis (XLRS), a retinal degenerative disease that disrupts retinal layers and forms cystic cavities. In addition to its structural function, RS1 is believed to play a role in retinal development.
van der Veen I, Koster C, Brink JBT, Kamermans M, Boon CJF.   +4 more
europepmc   +2 more sources

Stimulation of C-Kit+ Retinal Progenitor Cells by Stem Cell Factor Confers Protection Against Retinal Degeneration

Frontiers in Pharmacology, 2022
C-kit/CD117, expressed in a series of tissue-specific progenitor cells, plays an important role in tissue regeneration and tissue homeostasis. We previously demonstrated that organoid-derived c-kit+ retinal progenitor cells can facilitate the restoration
Xi Chen, Shanshan Li, Xiaoli Liu, Jingjie Zhao, Lanting Wu, Ran You, Yanling Wang   +6 more
doaj   +1 more source

Replica exchange molecular dynamics simulations reveal self-association sites in M-crystallin caused by mutations provide insights of cataract

Scientific Reports, 2021
Crystallins are ubiquitous, however, prevalence is seen in eye lens. Eye lens crystallins are long-lived and structural intactness is required for maintaining lens transparency and protein solubility. Mutations in crystallins often lead to cataract.
Sunita Patel, Ramakrishna V. Hosur
doaj   +1 more source

Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology

Cells, 2022
In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and organs represents a powerful approach to gain insight into those cellular and molecular mechanisms regulating human development.
Aleš Cvekl, Michael John Camerino
doaj   +1 more source

βB1-crystallin: thermodynamic profiles of molecular interactions. [PDF]

PLoS ONE, 2012
β-Crystallins are structural proteins maintaining eye lens transparency and opacification. Previous work demonstrated that dimerization of both βA3 and βB2 crystallins (βA3 and βB2) involves endothermic enthalpy of association (∼8 kcal/mol) mediated by ...
Monika B Dolinska, Paul T Wingfield, Yuri V Sergeev   +2 more
doaj   +1 more source

Molecular diagnosis of autosomal dominant congenital cataract in two families from North India reveals a novel and a known variant in GJA8 and GJA3

Frontiers in Pediatrics, 2022
AimsThe study aims to detect the underlying genetic defect in two autosomal dominant congenital cataract (ADCC) families.MethodsA detailed family history was collected, pedigrees were drawn, and slit-lamp examination and lens photography were performed ...
Vanita Vanita, Shiwali Goyal, Shailja Tibrewal, Shailja Tibrewal, Suma Ganesh   +4 more
doaj   +1 more source

Crystalline Boragermenes

Angewandte Chemie, 2020
AbstractBoragermene 3 featuring a double bond between the Ge and dicoordinate B atoms has been synthesized for the first time by reacting the cyclic (alkyl)(boryl)germylene–PMe3 adduct 1 with Cl2BN(SiMe3)2 followed by reductive dehalogenation with KC8.
Bin Rao, Rei Kinjo
openaire   +4 more sources