Science, 1937 Sumner, James B. and Dounce, Alexander L. Crystalline Catalase, 1937 ; https://digitalcommons.rockefeller.edu/pamphlets-offprints-and-reprints/1045/thumbnail ...
Sumner, James B., Dounce, Alexander L.
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Concurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens alpha-crystallin. [PDF]
PLoS ONE, 2008 Familial Danish Dementia (FDD) is an autosomal disease, which is distinguished by gradual loss of vision, deafness, progressive ataxia and dementia. Cataract is the first manifestation of the disease.
Ira Surolia +5 more
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Multiple aggregates and aggresomes of C-terminal truncated human αA-crystallins in mammalian cells and protection by αB-crystallin. [PDF]
PLoS ONE, 2011 Cleavage of 11 (αA162), 5 (αA168) and 1 (αA172) residues from the C-terminus of αA-crystallin creates structurally and functionally different proteins. The formation of these post-translationally modified αA-crystallins is enhanced in diabetes.
Ilangovan Raju +2 more
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Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts [PDF]
, 2003 Congenital cataracts are a major cause of bilateral visual impairment in childhood. We mapped the gene responsible for autosomal congenital cerulean cataracts to chromosome 2q33-35 in a four generation family of Moroccan descent. The maximum lod score (7.
Abitbol, M. +11 more
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Science, 1929 A method is described for the preparation of a crystalline protein from commercial pepsin preparations which has powerful peptic activity. The composition, optical activity, and proteolytic activity of this protein remain constant through seven successive crystallizations.
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Roles of TGFβ and FGF signals during growth and differentiation of mouse lens epithelial cell in vitro. [PDF]
, 2017 Transforming growth factor β (TGFβ) and fibroblast growth factor (FGF) signaling pathways play important roles in the proliferation and differentiation of lens epithelial cells (LECs) during development.
Gong, Xiaohua +5 more
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Analysis and update of the human aldehyde dehydrogenase (
Human Genomics, 2005 The aldehyde dehydrogenase (ALDH) gene superfamily encodes enzymes that are critical for certain life processes and detoxification via the NAD(P)+-dependent oxidation of numerous endogenous and exogenous aldehyde substrates, including pharmaceuticals and
Vasiliou Vasilis, Nebert Daniel W
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Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone. [PDF]
PLoS ONE, 2012 The transparency of the eye lens depends upon maintenance of the native state of the γ- and β-crystallins, which is aided by the abundant chaperones αA- and αB-crystallin.
Kate L Moreau, Jonathan A King
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Small heat-shock proteins: important players in regulating cellular proteostasis [PDF]
, 2015 Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection.
Carver, John A. +3 more
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Crystalline Nephropathies [PDF]
Archives of Pathology & Laboratory Medicine, 2012 Context.—The kidney is a favored site for crystal deposition because of the high concentration of ions and molecules reached at the level of the renal tubules in the course of filtration. This review focuses on crystalline nephropathies in 4 broad categories: (1) dysproteinemia- associated, (2) drug-induced, (3) calcium-containing, and (4) metabolic or
Leal C, Herlitz +2 more
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