PLoS ONE, 2020 Parkinson´s disease is characterized by the accumulation of proteinaceous aggregates in Lewy bodies and Lewy Neurites. The main component found in such aggregates is α-synuclein.
Ricardo Gaspar +2 more
doaj +1 more source
Identification and functional analysis of αB-crystallins in Pteromalus puparum
Frontiers in Physiology, 2023 Heat shock proteins, including αB-crystallins (CRYAB), are pivotal in cellular defense mechanisms and stress response. This study presents a comprehensive investigation of heat shock proteins (HSPs), with a specific focus on the CRYAB family, within the ...
Shuxing Lao +3 more
doaj +1 more source
An Insight on α-crystallin Interactions with Various Proteins in Systemic Disorders [PDF]
Journal of Stress Physiology & Biochemistry, 2023 αA- and αB- crystallins are the two principal components of the α-crystallin family of heat shock proteins which exhibit chaperone activity as well as cyto-protective function.
Aparajita Chakraborty +3 more
doaj
Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma. [PDF]
PLoS ONE, 2017 Purpose of this study was to investigate firstly specific proteomic changes within the retina in the course of an animal glaucoma model and to identify secondly new approaches for neuroprotective, therapeutic options in glaucoma by addressing those ...
Fabian Anders +8 more
doaj +1 more source
Crystalline bacterial catalase [PDF]
Biochemical Journal, 1947 It is now fifty-four years since Gottstein1 discovered that some bacteria are able to decompose hydrogen peroxide with evolution of gaseous oxygen, an activity he attributed to their possessing an intracellular enzyme which later came to be called ‘catalase’.
D, Herbert, J, Pinsent
openaire +3 more sources
Aggregation pathways of human γ D crystallin induced by metal ions revealed by time dependent methods [PDF]
PeerJ, 2020 Cataract formation is a slow accumulative process due to protein aggregates promoted by different factors over time. Zinc and copper ions have been reported to induce the formation of aggregates opaque to light in the human gamma D crystallin (HγD) in a ...
Arline Fernández-Silva +3 more
doaj +2 more sources
Changes in zebrafish (Danio rerio) lens crystallin content during development. [PDF]
, 2013 PurposeThe roles that crystallin proteins play during lens development are not well understood. Similarities in the adult crystallin composition of mammalian and zebrafish lenses have made the latter a valuable model for examining lens function.
Corbin, Rebecca W +4 more
core +1 more source
Tyrosine/Cysteine Cluster Sensitizing Human γD-Crystallin to Ultraviolet Radiation-Induced Photoaggregation in Vitro [PDF]
, 2013 Ultraviolet radiation (UVR) exposure is a major risk factor for age-related cataract, a protein-aggregation disease of the human lens often involving the major proteins of the lens, the crystallins.
King, Jonathan Alan +3 more
core +1 more source
Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, EarlyView.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein. [PDF]
, 1988 tau-Crystallin has been a major component of the cellular lenses of species throughout vertebrate evolution, from lamprey to birds. Immunofluorescence analysis of the embryonic turtle lens, using antiserum to lamprey tau-crystallin showed that the ...
de Jong, WW +6 more
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