Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong +7 more
wiley +1 more source
Functional Role of γ-Crystallin N in the Auditory Hindbrain. [PDF]
γ-crystallins are major components of the vertebrate lens but show expression in other tissues as well. Their extralenticular functions remain so far unclear.
Heiner Hartwich +5 more
doaj +1 more source
Transcriptional profiling of single fiber cells in a transgenic paradigm of an inherited childhood cataract reveals absence of molecular heterogeneity. [PDF]
Our recent single-cell transcriptomic analysis has demonstrated that heterogeneous transcriptional activity attends molecular transition from the nascent to terminally differentiated fiber cells in the developing mouse lens.
Bhat, Suraj P +6 more
core
Abstract Purpose To compare the inflammatory response in the eye after trabeculectomy to after phacoemulsification, focusing on anterior chamber flare (AC flare) and central macular thickness (CMT). Methods Data from 436 participants in two randomized controlled trials were analysed.
Yasmeen Ahmed +5 more
wiley +1 more source
Crystallins are regulated biomarkers for monitoring topical therapy of glaucomatous optic neuropathy. [PDF]
Optic nerve atrophy caused by abnormal intraocular pressure (IOP) remains the most common cause of irreversible loss of vision worldwide. The aim of this study was to determine whether topically applied IOP-lowering eye drugs affect retinal ganglion ...
Verena Prokosch +2 more
doaj +1 more source
Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein. [PDF]
tau-Crystallin has been a major component of the cellular lenses of species throughout vertebrate evolution, from lamprey to birds. Immunofluorescence analysis of the embryonic turtle lens, using antiserum to lamprey tau-crystallin showed that the ...
de Jong, WW +6 more
core
Potential of human γD-crystallin for hair damage repair : insights into the mechanical properties and biocompatibility [PDF]
The objective of this work was to develop a new strategy to physically ‘repair’ chemically damaged hair. Hence the human eye γD-crystallin, a protein from the superfamily characterized structurally by the Greek key motif, was studied.
Andersson +25 more
core +1 more source
Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics
Radiopacity is sometimes an essential characteristic of biomaterials that can help clinicians perform follow-ups during pre- and post-interventional radiological imaging. Due to their chemical composition and structure, most bioceramics are inherently radiopaque but can still be doped/mixed with radiopacifiers to increase their visualization during or ...
Maziar Montazerian +10 more
openaire +3 more sources
In vitro interactions of histones and α-crystallin
The aggregation of crystallins in lenses is associated with cataract formation. We previously reported that mutant crystallins are associated with an increased abundance of histones in knock-in and knockout mouse models.
Paul D. Hamilton, Usha P. Andley
doaj +1 more source
Comparison of the Lens Protein Profiles of Three Species of Ozark Salamanders [PDF]
The vertebrate lens has a high protein content (35%), 80-90% of which is composed of the soluble, lens-specific structural proteins, the crystallins. The lens protein profiles of urodelan species have been found to be qualitatively distinct.
Britton, James M.
core +2 more sources

