Results 51 to 60 of about 8,769 (230)
Advanced Science, EarlyView.Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija +22 more
wiley +1 more source
Transcriptional profiling of single fiber cells in a transgenic paradigm of an inherited childhood cataract reveals absence of molecular heterogeneity. [PDF]
, 2019 Our recent single-cell transcriptomic analysis has demonstrated that heterogeneous transcriptional activity attends molecular transition from the nascent to terminally differentiated fiber cells in the developing mouse lens.
Bhat, Suraj P +6 more
core
Potential of human γD-crystallin for hair damage repair : insights into the mechanical properties and biocompatibility [PDF]
, 2013 The objective of this work was to develop a new strategy to physically ‘repair’ chemically damaged hair. Hence the human eye γD-crystallin, a protein from the superfamily characterized structurally by the Greek key motif, was studied.
Andersson +25 more
core +1 more source
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, EarlyView.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
Crystallins are regulated biomarkers for monitoring topical therapy of glaucomatous optic neuropathy. [PDF]
PLoS ONE, 2013 Optic nerve atrophy caused by abnormal intraocular pressure (IOP) remains the most common cause of irreversible loss of vision worldwide. The aim of this study was to determine whether topically applied IOP-lowering eye drugs affect retinal ganglion ...
Verena Prokosch +2 more
doaj +1 more source
Future Postharvest and Food, EarlyView.By lowering oxidative stress and lens protein aggregation, nutraceuticals enriched with antioxidants may reduce the development of senile cataracts, demonstrating their potential as supplemental, non‐pharmacological cataract preventive methods. ABSTRACT This review explores the emerging evidence to accommodate the developing requirement of non ...
Moubani Dutta +2 more
wiley +1 more source
Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics
Materials, 2022 Radiopacity is sometimes an essential characteristic of biomaterials that can help clinicians perform follow-ups during pre- and post-interventional radiological imaging. Due to their chemical composition and structure, most bioceramics are inherently radiopaque but can still be doped/mixed with radiopacifiers to increase their visualization during or ...
Maziar Montazerian +10 more
openaire +3 more sources
In vitro interactions of histones and α-crystallin
Biochemistry and Biophysics Reports, 2018 The aggregation of crystallins in lenses is associated with cataract formation. We previously reported that mutant crystallins are associated with an increased abundance of histones in knock-in and knockout mouse models.
Paul D. Hamilton, Usha P. Andley
doaj +1 more source
Functional Role of γ-Crystallin N in the Auditory Hindbrain. [PDF]
PLoS ONE, 2016 γ-crystallins are major components of the vertebrate lens but show expression in other tissues as well. Their extralenticular functions remain so far unclear.
Heiner Hartwich +5 more
doaj +1 more source
Comparison of the Lens Protein Profiles of Three Species of Ozark Salamanders [PDF]
, 1979 The vertebrate lens has a high protein content (35%), 80-90% of which is composed of the soluble, lens-specific structural proteins, the crystallins. The lens protein profiles of urodelan species have been found to be qualitatively distinct.
Britton, James M.
core +2 more sources