A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid [PDF]
, 2016 published_or_final_versio
Cheng, MH +7 more
core +1 more source
The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring
Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz +8 more
wiley +1 more source
Mechanism of action of VP1-001 in cryAB(R120G)-associated and age-related cataracts [PDF]
, 2019 PurposeWe previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind ...
Andley, Usha P. +10 more
core +2 more sources
Age-related changes in local water and protein content of human eye lenses measured by Raman microspectroscopy [PDF]
, 1991 The Raman microspectroscopic method was used to determine the local water and protein content in human lenses. In 18 lenses of varying age position-defined water/protein content measurements were carried out along the visual and the equatorial axis.\ud ...
Greve, J. +3 more
core +3 more sources
Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease
Advanced Science, Volume 13, Issue 4, 19 January 2026.Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley +1 more source
The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function [PDF]
PeerJ, 2017 Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or ...
Mason Posner +9 more
doaj +2 more sources
Protein & Cell, 2016 β/γ-Crystallins are predominant structural proteins in the cytoplasm of lens fiber cells and share a similar fold composing of four Greek-key motifs divided into two domains.
Liang-Bo Qi +5 more
doaj +1 more source
Interaction of C-terminal truncated human alphaA-crystallins with target proteins. [PDF]
PLoS ONE, 2008 Significant portion of alphaA-crystallin in human lenses exists as C-terminal residues cleaved at residues 172, 168, and 162. Chaperone activity, determined with alcohol dehydrogenase (ADH) and betaL-crystallin as target proteins, was increased in alphaA(
Anbarasu Kumarasamy, Edathara C Abraham
doaj +1 more source
Expression of the gene for main intrinsic polypeptide (MIP): separate spatial distributions of MIP and beta-crystallin gene transcripts in rat lens development [PDF]
, 1988 The main intrinsic polypeptide (MIP) is the major protein present in the lens fiber cell membrane and is the product of a gene which, as far as is known, is expressed only in the lens.
Chung, Johnson +3 more
core +1 more source
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source