Results 61 to 70 of about 8,769 (230)
Age-related changes in local water and protein content of human eye lenses measured by Raman microspectroscopy [PDF]
, 1991 The Raman microspectroscopic method was used to determine the local water and protein content in human lenses. In 18 lenses of varying age position-defined water/protein content measurements were carried out along the visual and the equatorial axis.\ud ...
Greve, J. +3 more
core +3 more sources
Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy
PROTEOMICS, EarlyView.ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling +6 more
wiley +1 more source
Mechanism of action of VP1-001 in cryAB(R120G)-associated and age-related cataracts [PDF]
, 2019 PurposeWe previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind ...
Andley, Usha P. +10 more
core +2 more sources
Integrative Zoology, EarlyView.Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong +7 more
wiley +1 more source
The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function [PDF]
PeerJ, 2017 Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or ...
Mason Posner +9 more
doaj +2 more sources
Carbon turnover in the water-soluble protein of the adult human lens. [PDF]
, 2013 PurposeHuman eye lenses contain cells that persist from embryonic development. These unique, highly specialized fiber cells located at the core (nucleus) of the lens undergo pseudo-apoptosis to become devoid of cell nuclei and most organelles. Ostensibly
Buchholz, Bruce A +7 more
core +1 more source
A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid [PDF]
, 2016 published_or_final_versio
Cheng, MH +7 more
core +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To compare the inflammatory response in the eye after trabeculectomy to after phacoemulsification, focusing on anterior chamber flare (AC flare) and central macular thickness (CMT). Methods Data from 436 participants in two randomized controlled trials were analysed.
Yasmeen Ahmed +5 more
wiley +1 more source
PLoS ONE, 2018 The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life.
Usha P Andley +3 more
doaj +1 more source
Interaction of C-terminal truncated human alphaA-crystallins with target proteins. [PDF]
PLoS ONE, 2008 Significant portion of alphaA-crystallin in human lenses exists as C-terminal residues cleaved at residues 172, 168, and 162. Chaperone activity, determined with alcohol dehydrogenase (ADH) and betaL-crystallin as target proteins, was increased in alphaA(
Anbarasu Kumarasamy, Edathara C Abraham
doaj +1 more source