Results 71 to 80 of about 15,579 (272)

Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.

PLoS ONE, 2018
The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life.
Usha P Andley, Eric Tycksen, Brittney N McGlasson-Naumann, Paul D Hamilton   +3 more
doaj   +1 more source

Identification of subunit-subunit interaction sites in αA-WT crystallin and mutant αA-G98R crystallin using isotope-labeled cross-linker and mass spectrometry. [PDF]

PLoS ONE, 2013
Cataract is characterized by progressive protein aggregation and loss of vision. α-Crystallins are the major proteins in the lens responsible for maintaining transparency.
Rama Kannan, Puttur Santhoshkumar, Brian P Mooney, K Krishna Sharma   +3 more
doaj   +1 more source

Carbon turnover in the water-soluble protein of the adult human lens. [PDF]

, 2013
PurposeHuman eye lenses contain cells that persist from embryonic development. These unique, highly specialized fiber cells located at the core (nucleus) of the lens undergo pseudo-apoptosis to become devoid of cell nuclei and most organelles. Ostensibly
Buchholz, Bruce A, Falso, Miranda JS, FitzGerald, Paul G, Hammock, Bruce D, Lango, Jozsef, Nambiar, Krishnan P, Rocke, David M, Stewart, Daniel N   +7 more
core   +1 more source

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

Ca2+ binding enhanced mechanical stability of an archaeal crystallin. [PDF]

PLoS ONE, 2014
Structural topology plays an important role in protein mechanical stability. Proteins with β-sandwich topology consisting of Greek key structural motifs, for example, I27 of muscle titin and (10)FNIII of fibronectin, are mechanically resistant as shown ...
Venkatraman Ramanujam, Hema Chandra Kotamarthi, Sri Rama Koti Ainavarapu   +2 more
doaj   +1 more source

Site-directed mutations in the C-terminal extension of human aB-Crystalline affect chaperone function and block amyloid fibril formation [PDF]

, 2007
Copyright: 2007 Treweek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
A Karshikoff, A Karshikoff, A Rekas, AF van Rijk, B Raman, BK Das, C Cambillau, CB Anfinsen, CB Anfinsen, CD Syme, Danielle M. Williams, DC Thorn, DM Hatters, DP Kreil, Edathara Abraham, FA Burstein, GJ Stege, HA Sathish, HA Sathish, HE Ecroyd, HE White, Heath Ecroyd, HMJ Farrell, J Frydman, J Horwitz, J Horwitz, J-H Liao, JA Aquilina, JA Aquilina, JA Carver, JA Carver, JA Carver, JA Carver, JC Young, JG Ghosh, JI Clark, JJN Liang, JM Barral, John A. Carver, K Kamei, K Kato, KC Giese, KK Kim, L Nielsen, L Takemoto, LL Randall, LVS Kumar, M Ehrnsperger, M Haslbeck, M Stefani, Mark J. Walker, MJ Kelley, MJ Kronman, MP Bova, MR Leroux, N Ochi, P Fernando, P Thampi, R Copeland, R Klemenz, RA Kammerer, RA Lindner, RA Lindner, RHPH Smulders, RLM van Montfort, S Bera, S Studer, Sarah Meehan, SM Kelly, SY Pasta, Teresa M. Treweek, TM Treweek, UP Andley, WW de Jong, Y Sun, YC Kudva   +75 more
core   +4 more sources

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Spatial Analysis of Single Fiber Cells of the Developing Ocular Lens Reveals Regulated Heterogeneity of Gene Expression

iScience, 2018
Summary: The developing eye lens presents an exceptional paradigm for spatial transcriptomics. It is composed of highly organized long, slender transparent fiber cells, which differentiate from the edges of the anterior epithelium of the lens (equator ...
Rajendra K. Gangalum, Dongjae Kim, Raj K. Kashyap, Serghei Mangul, Xinkai Zhou, David Elashoff, Suraj P. Bhat   +6 more
doaj   +1 more source

From A. rhizogenes RolD to Plant P5CS: Exploiting Proline to Control Plant Development [PDF]

, 2018
The capability of the soil bacterium Agrobacterium rhizogenes to reprogram plant development and induce adventitious hairy roots relies on the expression of a few root-inducing genes (rol A, B, C and D), which can be transferred from large virulence ...
Costantino, Paolo, Mattioli, Roberto, Trovato, Maurizio   +2 more
core   +1 more source

A Comparative Analysis of Receptor‐Like Kinases in Chlorophyta Reveals the Presence of Putative Cell Wall Integrity Sensors

Physiologia Plantarum, Volume 178, Issue 1, January/February 2026.
ABSTRACT Receptor‐like kinases (RLKs) detect external and internal signals, triggering responses essential for growth and adaptation. Among internal cues, cell wall integrity (CWI) sensing plays a key role, as changes in cell wall structure activate responses critical for development and defense.
Demetrio Marcianò, Bastien G. Dauphin, Fabian Basso, Christiane Funk, Laura Bacete   +4 more
wiley   +1 more source