Results 81 to 90 of about 8,769 (230)
Structural integrity of the Greek key motif in βγ-crystallins is vital for central eye lens transparency. [PDF]
PLoS ONE, 2013 BACKGROUND: We highlight an unrecognized physiological role for the Greek key motif, an evolutionarily conserved super-secondary structural topology of the βγ-crystallins.
Venkata Pulla Rao Vendra +5 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract The purpose of this exploratory investigation was to determine if acute post‐exercise skeletal muscle myosin heavy chain fragmentation (MyHCfrag) coincides with alterations in molecular chaperones and proteolytic enzymes, select markers of mammalian target of rapamycin complex 1 (mTORC1) signalling, and/or specific gene expression signatures ...
Dakota R. Tiede +10 more
wiley +1 more source
Indian Journal of Ophthalmology, 2002 Purpose: To develop and evaluate an immunoanalytical method for the detection of β - and g-crystallins and anti-crystallin antibodies. Materials and Methods: Beta and g-crystallins isolated from rat lens were used as immunogens to raise ...
Nayak Sujatha +2 more
doaj
A novel non-lens betagamma-crystallin and trefoil factor complex from amphibian skin and its functional implications. [PDF]
PLoS ONE, 2008 In vertebrates, non-lens betagamma-crystallins are widely expressed in various tissues, but their functions are unknown. The molecular mechanisms of trefoil factors, initiators of mucosal healing and being greatly involved in tumorigenesis, have remained
Shu-Bai Liu +6 more
doaj +1 more source
Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu +10 more
wiley +1 more source
Identification of hydrophobic sites on UV irradiated beta crystallins from bovine lenses [abstract] [PDF]
, 2004 only availableFaculty Mentor: Dr. Krishna Sharma, OphthalmologyThe lens of the eye is an avascular tissue of a complex network of proteins surrounded by a capsule.
Rednam, Rukmini
core
Cataract-associated P23T γ 3D-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH [PDF]
, 2017 Cataracts cause vision loss through the large-scale aggregation of eye lens proteins as a result of ageing or congenital mutations. The development of new treatments is hindered by uncertainty about the nature of the aggregates and their mechanism of ...
Boatz, JC +4 more
core +1 more source
Protein Science, Volume 35, Issue 4, April 2026.Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova +2 more
wiley +1 more source
Exploring the Universe within the Human Lens Through Raman Spectroscopy
Delhi Journal of Ophthalmology, 2017 Ever since the emergence of refined modalities of cataract surgery, the looming question has been the same - How to improve the technique, to minimize manipulation of biological components and optimize the end result? The most recent development has been,
Praveen K Malik +3 more
doaj +1 more source
Association of High Myopia with Crystallin Beta A4 (CRYBA4) Gene Polymorphisms in the Linkage-Identified MYP6 Locus [PDF]
, 2012 Background: Myopia is the most common ocular disorder worldwide and imposes tremendous burden on the society. It is a complex disease. The MYP6 locus at 22 q12 is of particular interest because many studies have detected linkage signals at this interval.
Fung, WY +4 more
core +1 more source