Results 141 to 150 of about 423,178 (287)

Acta Crystallographica Section A: Foundations of Crystallography [PDF]

, 2005
D. Schwarzenbach
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Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

MicroED: Unveiling the Structural Chemistry of Plant Biomineralisation

Molecules
Plants are able to produce various types of crystals through metabolic processes, serving functions ranging from herbivore deterrence to photosynthetic efficiency.
Damian Trzybiński, Marcin Ziemniak, Barbara Olech, Szymon Sutuła, Tomasz Góral, Olga Bemowska-Kałabun, Krzysztof Brzost, Małgorzata Wierzbicka, Krzysztof Woźniak   +8 more
doaj   +1 more source

Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design

, 2018
Francesco Manzoni, Johan Wallerstein, Tobias E. Schrader, Andreas Ostermann, Leighton Coates, Mikael Akke, Matthew P. Blakeley, Esko Oksanen, Derek T. Logan   +8 more
openalex   +1 more source

Careers in industry following a PhD in crystallography [PDF]

, 2015
Rachel Macmaster
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Dual Regulation of Molecular Rigidity and Orbital Engineering of Pt(II) Emitters for High‐Performance Deep‐Blue OLEDs

Advanced Science, EarlyView.
Four novel tetradentate Pt(II) emitters (PtCY, PtCY‐F, PtCY‐tBu, PtCY‐tBuF) are designed through synergistic strategy of molecular orbital engineering and steric hindrance effect. PtCY‐tBuF‐based device B4 achieves a high maximum luminance of 45 621 cd m−2, and record high external quantum efficiency (EQE) of 27.1%, 24.3%, and 21.7% at high brightness ...
Chengyao Zhang, Kewei Xu, Yun‐Fang Yang, Yuanbin She, Guijie Li   +4 more
wiley   +1 more source

Martensite crystallography and chemistry in dual phase and fully martensitic steels

, 2018
Cheng-Ran Du, J.P.M. Hoefnagels, Sebastian Kölling, M.G.D. Geers, Jilt Sietsma, Roumen Petrov, Vitaliy Bliznuk, P. M. Koenraad, D. Schryvers, Behnam Amin-Ahmadi   +9 more
openalex   +2 more sources

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Infrared protein crystallography [PDF]

, 2011
McGeehan, John, Ravelli, Raimond B. G., Sage, J. Timothy, Van Thor, Jasper J., Weik, Martin, Zhang, Yunbin   +5 more
core   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source