Results 11 to 20 of about 37,852,591 (164)

Antibacterial and Antifungal Activities of Poloxamer Micelles Containing Ceragenin CSA-131 on Ciliated Tissues [PDF]

Molecules, 2018
Ceragenins were designed as non-peptide mimics of endogenous antimicrobial peptides, and they display broad-spectrum antibacterial and antifungal activities, including the ability to eradicate established biofilms.
Marjan M. Hashemi, Brett S. Holden, Maddison F. Taylor, John Wilson, Jordan Coburn, Brian Hilton, Tania Nance, Shawn Gubler, Carl Genberg, Shenglou Deng, Paul B. Savage   +10 more
doaj   +6 more sources

Peanut-shaped gold nanoparticles with shells of ceragenin csa-131 display the ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model [PDF]

Cancers (Basel), 2021
Gold nanoparticles-assisted delivery of antineoplastics into cancerous cells is presented as an effective approach for overcoming the limitations of systemic chemotherapy.
Joanna Depciuch, Natalia Marcińczyk, Justyna Klimek, Michał T. Marzec, Robert Bucki, Marzec, Michał T., Piktel, Ewelina, Marcińczyk, Natalia, Klimek, Justyna, Parlińska-Wojtan, Magdalena, Paul B. Savage, Magdalena Parlińska-Wojtan, Suprewicz, Łukasz, Wolak, Przemysław, Bucki, Robert, Piotr M. Zieliński, Oscilowska, Ilona, Chabielska, Ewa, Ewa Chabielska, Ilona Oscilowska, Przemysław Wolak, Głuszek, Katarzyna, Ewelina Piktel, Łukasz Suprewicz, Depciuch, Joanna, Savage, Paul B., Katarzyna Głuszek, Zieliński, Piotr M.   +27 more
core   +8 more sources

In Vitro Activities of the Cationic Steroid Antibiotics CSA-13, CSA-131, CSA-138, CSA-142, and CSA-192 Against Carbapenem-resistant Pseudomonas aeruginosa [PDF]

Turk J Pharm Sci, 2020
Objectives: Pseudomonas aeruginosa is an important opportunistic pathogen that is difficult to treat because of the antibiotic resistance that has developed in recent years. Increasing carbapenem resistance has led to a rise in hospital infections caused
Savage, Paul, Avci, Nevin Meltem, Bozkurt Guzel, Cagla   +2 more
core   +4 more sources

Bactericidal activity of ceragenin CSA-13, CSA-44 and CSA-131 against bacteria causing bloodstream infections [PDF]

Frontiers in Microbiology
IntroductionThe constantly growing resistance of bacteria causing bloodstream infections and the lack of alternative antibiotics generate the need to develop new therapeutic strategies. In this study, the antibacterial properties of synthetic cholic acid
Angelika Mańkowska, Paulina Paprocka, Łukasz Suprewicz, Agata Lesiak, Kamila Fortunka, Grzegorz Król, Jakub Spałek, Jakub Spałek, Sławomir Okła, Sławomir Okła, Bonita Durnaś, Tamara Daniluk, Ewelina Piktel, Paul B. Savage, Robert Bucki, Robert Bucki   +15 more
doaj   +5 more sources

Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells [PDF]

International Journal of Nanomedicine, 2020
Ewelina Piktel,1 Karolina H Markiewicz,2 Agnieszka Z Wilczewska,2 Tamara Daniluk,1 Sylwia Chmielewska,1 Katarzyna Niemirowicz-Laskowska,1 Joanna Mystkowska,3 Paulina Paprocka,4 Paul B Savage,5 Robert Bucki1,4 1Department of Medical Microbiology and ...
Piktel E, Markiewicz KH, Wilczewska AZ, Daniluk T, Chmielewska S, Niemirowicz-Laskowska K, Mystkowska J, Paprocka P, Savage PB, Bucki R   +9 more
doaj   +5 more sources

Correction: Bucki et al. Bactericidal Properties of Rod-, Peanut-, and Star-Shaped Gold Nanoparticles Coated with Ceragenin CSA-131 against Multidrug-Resistant Bacterial Strains. Pharmaceutics 2021, 13, 425 [PDF]

Pharmaceutics
In the original publication [...]
Sylwia Joanna Chmielewska, Karol Skłodowski, Joanna Depciuch, Piotr Deptuła, Ewelina Piktel, Krzysztof Fiedoruk, Patrycja Kot, Paulina Paprocka, Kamila Fortunka, Tomasz Wollny, Przemysław Wolak, Magdalena Parlinska-Wojtan, Paul B. Savage, Robert Bucki   +13 more
doaj   +3 more sources

Erratum: Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells [Corrigendum]. [PDF]

Int J Nanomedicine, 2023
Therapeutic efficiency of ceragenins against cancers may be limited by lack of their hemocompatibility when high concentrations of molecules are required to reach a desired result. Synergistic effects observed upon administration of anticancer agents and metal nanoparticles may provide an opportunity to limit toxicity of immobilized ceragenins on the ...
Piktel, Ewelina, Markiewicz, Karolina H., Wilczewska, Agnieszka Z., Daniluk, Tamara, Chmielewska, Sylwia, Niemirowicz-Laskowska, Katarzyna, Mystkowska, Joanna, Paprocka, Paulina, Savage, Paul B., Bucki, Robert   +9 more
europepmc   +8 more sources

Investigation of the Antifungal Activities of the Cationic Steroid Antibiotic CSA-8, CSA-13, CSA-44, CSA-131 and CSA-138 Against Candida albicans Isolated from Blood Cultures [PDF]

ANKEM Dergisi, 2014
Cerageninler, antimikrobiyal peptitlere benzer aktivite gösteren, yeni bir grup katyonik steroid antimikrobiyal molekül- lerdir. Bu çalışmada kan kültürlerinden izole edilmiş Candida albicans suşlarına karşı katyonik steroid antibiyotiklerden olan CSA-8,
Çağla Güzel Bozkurt, Maryam Tüysüz, Paul B. Savage, Neşe İnan   +3 more
core   +3 more sources

Conformation‐Selective Binding Domains of Intramolecular Chemically Induced Protein Dimerisation Systems [PDF]

Angewandte Chemie, Volume 138, Issue 46, 9 November 2026.
Intramolecular chemically induced dimerisation transforms FK506‐ and cyclosporine A‐responsive protein pairs into high‐affinity pseudo‐allosteric switches. Holo‐selective binders isolated by mRNA display convert these switches into gain‐of‐signal biosensors and ultrasensitive ELISAs, enabling direct quantification of both immunosuppressants in ...
Zhenling Cui, Zhong Guo, Yi Jin Liew, Alessandro T. Caputo, Maria M. Fiorito, Cagla Ergun Ayva, Roxane Mutschler, Mayra Barrios Leguarca, Sophia Newton, Gia Nghi Lam, Robert Speight, Brett McWhinney, Yanulla Essie Georges, Carel Pretorius, Jacobus P.J. Ungerer, Kirill Alexandrov   +15 more
wiley   +3 more sources

FLIP Measurements Predict Short‐Term Outcomes After Singular EsoFLIP Dilation in Patients With Achalasia [PDF]

Neurogastroenterology &Motility, Volume 38, Issue 11, November 2026.
Changes in EGJ diameter and EGJ cross‐sectional area during EsoFLIP dilation predict short‐term symptomatic response. Intra‐procedural FLIP may help assess treatment adequacy, but prospective validation is required before clinical application. ABSTRACT Background FLIP enables real‐time measurement of esophagogastric junction (EGJ) dimensions and ...
Johann Stuby, Valeria Schindler, Joel Schnellmann, Jessica Martinez, Amanda Bianca, Daniel Pohl   +5 more
wiley   +2 more sources