Results 21 to 30 of about 37,852,591 (164)

Mitigating HLA Disparity in AML Transplantation: Comparable Outcomes After Haploidentical and 9/10 Mismatched Unrelated Donor Transplantation With Treosulfan and PTCy [PDF]

American Journal of Hematology, Volume 101, Issue 11, Page 2736-2745, November 2026.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a potentially curative strategy for acute myeloid leukemia (AML), but the impact of HLA disparity in the era of posttransplant cyclophosphamide (PTCy) and reduced‐toxicity conditioning remains unclear. We performed an EBMT registry study including 275 adult AML patients in first
Daniele Avenoso, Mirko Farina, Michele Malagola, Yves Chalandon, Giorgia Saporiti, Annalisa Imovilli, Enrico Derenzini, Peter Remenyi, Massimo Martino, Maija Itala‐Remes, Renato Fanin, Didier Blaise, Desiree Kunadt, Arancha Bermudez Rodriguez, Franca Fagioli, Thomas Schroeder, Irene Cavattoni, Maud Ngoya, Mohamed Houhou, Mohamad Mohty, Eolia Brissot, Fabio Ciceri   +21 more
wiley   +2 more sources

Ceragenins in Combination with Ivacaftor Prevent the Formation of Biofilm by Bacteria That Cause Rhinosinusitis [PDF]

Pharmaceutics
Background/Objectives: Ceragenins (CSAs) maintain strong antibacterial activity even in cystic fibrosis (CF) sputum. Ivacaftor (IVA), a CF transmembrane regulator modulator, provides significant clinical benefits in CF therapy. Based on these properties,
Szczepan Kaliniak, Piotr Deptuła, Jakub Spałek, Mariusz Sawieljew, Sylwia Chmielewska-Deptuła, Tamara Daniluk, Agata Lesiak, Bonita Durnaś, Paul B. Savage, Ewelina Piktel, Robert Bucki, Sławomir Okła   +11 more
doaj   +2 more sources

In vitroassessment of CSA-131 and CSA-131 poloxamer form for the treatment ofStenotrophomonas maltophiliainfections in cystic fibrosis

Journal of Antimicrobial Chemotherapy, 2020
AbstractBackgroundStenotrophomonas maltophilia is a Gram-negative bacterium resistant to several antibiotics and its prevalence in cystic fibrosis (CF) patients is increasing.ObjectivesTo evaluate the effects of ceragenins, non-peptide mimics of antimicrobial peptides, against both planktonic and biofilm forms of S.
Özlem Oyardi, Paul B Savage, Zayre Erturan, Cagla Bozkurt-Guzel   +3 more
openaire   +3 more sources

Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection

Scientific Reports, 2022
Ceragenins (CSAs) are synthetic, lipid-based molecules that display activities of natural antimicrobial peptides. Previous studies demonstrated their high in vitro activity against pathogens causing urinary tract infections (UTIs), but their efficiency ...
Urszula Wnorowska, Ewelina Piktel, Piotr Deptuła, Tomasz Wollny, Grzegorz Król, Katarzyna Głuszek, Bonita Durnaś, Katarzyna Pogoda, Paul B. Savage, Robert Bucki   +9 more
doaj   +1 more source

Childhood sexual abuse history amplifies the link between disease burden and inflammation among older adults with HIV

Brain, Behavior, & Immunity - Health, 2021
As they age, people living with HIV (PLWH) experience greater rates of inflammation-related health conditions compared to their HIV-negative peers. Because early life adversity can exaggerate proinflammatory effects of later physiological challenges ...
Heather M. Derry, Carrie D. Johnston, Mark Brennan-Ing, Stephen Karpiak, Chelsie O. Burchett, Yuan-Shan Zhu, Eugenia L. Siegler, Marshall J. Glesby   +7 more
doaj   +1 more source

Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo

BMC Microbiology, 2017
Background Cationic antibacterial peptides (CAPs) and synthetic molecules mimicking the amphiphilic structure of CAPs, such as ceragenins, are promising compounds for the development of new antimicrobials.
Bonita Durnaś, Ewelina Piktel, Marzena Wątek, Tomasz Wollny, Stanisław Góźdź, Jolanta Smok-Kalwat, Katarzyna Niemirowicz, Paul B. Savage, Robert Bucki   +8 more
doaj   +1 more source

Ultrasound diagnosis of transverse sinus hypoplasia using flow profiles of the internal jugular vein. [PDF]

PLoS ONE, 2017
Accurate diagnosis of subtypes of transverse sinus (TS) hypoplasia requires more expensive methods like magnetic resonance (MR) imaging. We hypothesized ultrasound findings of the internal jugular vein (IJV) can be surrogate indicators for diagnosis of ...
A-Ching Chao, Ke Han, Feng-Chi Chang, Hung-Yi Hsu, Chih-Ping Chung, Wen-Yung Sheng, Lung Chan, Jiang Wu, Han-Hwa Hu   +8 more
doaj   +1 more source

Ceragenins exhibit bactericidal properties that are independent of the ionic strength in the environment mimicking cystic fibrosis sputum

Frontiers in Microbiology, 2023
The purpose of the work was to investigate the impact of sodium chloride (NaCl) on the antimicrobial efficacy of ceragenins (CSAs) and antimicrobial peptides (AMPs) against bacterial and fungal pathogens associated with cystic fibrosis (CF) lung ...
Karol Skłodowski, Łukasz Suprewicz, Sylwia Joanna Chmielewska-Deptuła, Szczepan Kaliniak, Sławomir Okła, Sławomir Okła, Magdalena Zakrzewska, Łukasz Minarowski, Robert Mróz, Tamara Daniluk, Paul B. Savage, Krzysztof Fiedoruk, Robert Bucki   +12 more
doaj   +1 more source

Offsetting the cost of Community Support Agriculture (CSA) for low-income families: Perceptions and experiences of CSA farmers and members

, 2021
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is ...
Jilcott Pitts, Stephanie B., Alice S. Ammerman, Jane Kolodinsky, Karla L. Hanson, Amari Sealey, Jared T. McGuirt, Rebecca Seguin-Fowler, Marilyn Sitaker, Emily H. Belarmino, Florence Becot, Stephanie B. Jilcott Pitts, Leah Connor Volpe, Weiwei Wang   +12 more
core   +1 more source

Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells [Corrigendum]

International Journal of Nanomedicine, 2023
Piktel E, Markiewicz KH, Wilczewska AZ, et al. Int J Nanomedicine. 2020;15:4573–4589. It has been brought to the authors attention that Figure 6E showing nanosystem-mediated DNA fragmentation in DLD-1 colorectal cancer cells is a duplicate of part
Piktel E, Markiewicz KH, Wilczewska AZ, Daniluk T, Chmielewska S, Niemirowicz-Laskowska K, Mystkowska J, Paprocka P, Savage PB, Bucki R   +9 more
doaj