Results 51 to 60 of about 10,378 (206)

Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy. [PDF]

, 2018
PurposePediatric diffuse midline glioma (DMG) are highly malignant tumors with poor clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M (H3K27M) mutation, which correlates with a poorer clinical outcome, and is also used as a ...
Aboian, Mariam S, Kline, Cassie, Cha, Soonmee, Berens, Michael E, Kambhampati, Madhuri, Packer, Roger J, Hwang, Eugene I, Nazarian, Javad, Myseros, John S, Panditharatna, Eshini, Warren, Katherine E, Crawford, John R, Kilburn, Lindsay B, Magge, Suresh N, Resnick, Adam C, Prados, Michael, Gordish-Dressman, Heather, Mueller, Sabine, Gupta, Nalin, Liang, Winnie S   +19 more
core   +1 more source

Liquid biopsy in gliomas: A RANO review and proposals for clinical applications [PDF]

, 2022
BACKGROUND: There is an extensive literature highlighting the utility of blood-based liquid biopsies in several extracranial tumors for diagnosis and monitoring.
Vogelbaum, Michael A, van den Bent, Martin J; https://orcid.org/, Ahluwalia, Manmeet S, van den Bent, Martin J.; id_orcid, Ahluwalia, Manmeet S., Wen, Patrick Y, Galanis, Evanthia; https://orcid.org/, Warren, Katherine E; https://orcid.org/, Le Rhun, Émilie; https://orcid.org/, Jaeckle, Kurt A., van den Bent, Martin J, Thon, Niklas, Weller, Michael; https://orcid.org/, Mellinghoff, Ingo K, Wen, Patrick Y., Chang, Susan M, Chang, Susan M., De Groot, John F, Le Rhun, Emilie, Mellinghoff, Ingo K., De Groot, John F., Seoane, Joan, Weller, Michael, Warren, Katherine E., Gilbert, Mark R., Rudà, Roberta, Umemura, Yoshie, Galanis, Evanthia, Warren, Katherine E, Soffietti, Riccardo; https://orcid.org/, Bettegowda, Chetan, Gilbert, Mark R, Vogelbaum, Michael A., Jaeckle, Kurt A, Soffietti, Riccardo, van den Bent, Martin J.   +35 more
core   +1 more source

DataSheet_1_Unique Genomic Alterations of Cerebrospinal Fluid Cell-Free DNA Are Critical for Targeted Therapy of Non-Small Cell Lung Cancer With Leptomeningeal Metastasis.pdf [PDF]

, 2021
We reported unique molecular features of cerebrospinal fluid (CSF) of nonsmall cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM), suggesting establishing CSF as a better liquid biopsy in clinical practices.
Liyun Miao (5478500), Chengyun Yao (9422990), Guoren Zhou (3536906), Qi Zhao (124612), Hongping Xia (137466), Yanzhe Yu (11518324), Yang W. Shao (3612329), Hui Li (32376), Yongsheng Wang (169356), Mingke Shi (11518321), Hourong Cai (6309875), Ruixue Xia (10276163), Ming Li (91180), Yan Li (23143), Feng Jiang (95012)   +14 more
core   +1 more source

Cerebrospinal fluid: A unique source of circulating tumor DNA with broad clinical applications

Translational Oncology, 2023
Malignancies involving the central nervous system present unique challenges for diagnosis and monitoring due to the difficulties and risks of direct biopsies and the low specificity and/or sensitivity of other techniques for assessment.
Richard A. Hickman, Alexandra M. Miller, Maria E. Arcila   +2 more
doaj   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Detection of EGFR Mutations in Cerebrospinal Fluid of EGFR-Mutant Lung Adenocarcinoma With Brain Metastases

Frontiers in Oncology, 2021
BackgroundWe aimed to investigate the feasibility of detecting epidermal growth factor receptor (EGFR) mutations in cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) and plasma of advanced lung adenocarcinoma (LADC) with brain metastases (BMs) by ...
Liang Shi, Junfang Tang, Hong Tao, Lili Guo, Weihua Wu, Hongbo Wu, Zichen Liu, Li Tong, Wei Wu, Hongxia Li, Qiyi Meng, Liyan Xu, Nanying Che, Zhe Liu   +13 more
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Recommendations for using molecular assays on liquid biopsy: the first document provided by intersociety Group AIOM, SIF, SIAPEC-IAP, SIBioC [PDF]

, 2019
Liquid biopsy in cancer patients is mainly based on the analysis of circulating tumor DNA (ctDNA) enriched from biological fluids. This approach has more recently been proposed for the detection of oncogenic alterations in blood, cerebrospinal fluid (CSF)
Barberis M, Crino L., Marchio C., Gori S., Truini M., Gori S, Capoluongo E., Marchetti A, Del Re M, Marchetti A., Sapino A, Truini M, Normanno N, Danesi R., Danesi R, Bianchi AS, Russo A, Bianchi A. S., Normanno N., Capoluongo E, Venesio T, Marchiò C, Barberis M., Pinto C., Sapino A., Pinto C, Crinò L, Venesio T., Re M. D., Russo A.   +29 more
core   +1 more source

Reply to “Improving Specificity of CSF Liquid Biopsy for Genetic Testing” [PDF]

Annals of Neurology, 2021
Seyeon Kim, Sara Baldassari, Stéphanie Baulac, Jeong Ho Lee   +3 more
openaire   +2 more sources

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source