Results 31 to 40 of about 1,761,915 (233)

Image_1_Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis.jpeg

, 2022
BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving
Chunhui Li (501186), Lijian Zhang (387002), Hanbin Wang (1556056), Luxuan Wang (14276447), Chuan Fang (11911301)   +4 more
core   +1 more source

Cerebrospinal fluid circulating tumor DNA depicts profiling of brain metastasis in NSCLC

Molecular Oncology, 2023
Brain metastasis (BM) genetically diverges from the primary tumor in non‐small‐cell lung cancer (NSCLC). Hence, accurately capturing clinically relevant alterations is pivotal for the delivery of targeted therapies.
Jun Wu, Zhiqiang Liu, Tianxiang Huang, Ying Wang, Meng Meng Song, Tao Song, Gretchen Long, Xiaobing Zhang, Xi Li, Longbo Zhang   +9 more
doaj   +1 more source

Overview of liquid biopsy

, 2022
New studies are mainly focused on the new, minimally invasive biomarkers presenting in body fluids as the real-time representative of tumors, entitled “liquid biopsy.” Liquid biopsy contains tumor-derived cells, nucleic acids (DNA, RNA), and tumor ...
Yarandi V. A., Aghamir S. M. K., Khatami F., Rezaeian A., Fiorentino M.   +4 more
core   +1 more source

Simultaneous primary cancer occurrence of melanoma and pulmonary adenocarcinoma in leptomeningeal metastases: a case report

BMC Cancer, 2019
Background Leptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors. Diagnosis relies predominantly on neurological, radiographic, and cerebrospinal fluid (CSF) assessments.
Ann-Kathrin Stoppek, Sied Kebir, Andreas Junker, Kathy Keyvani, Stefan Zülow, Lazaros Lazaridis, Teresa Schmidt, Daniela Pierscianek, Martin Stuschke, Ulrich Sure, Christoph Kleinschnitz, Björn Scheffler, Lisa Zimmer, Martin Glas   +13 more
doaj   +1 more source

Liquid biopsy and glioblastoma

Exploration of Targeted Anti-tumor Therapy, 2023
Glioblastoma is the most common and malignant primary brain tumor. Despite a century of research efforts, the survival of patients has not significantly improved.
Robert H. Eibl, Markus Schneemann
doaj   +1 more source

Epidermal Growth Factor Receptor T790M Mutation Testing in Non-Small Cell Lung Cancer: An International Collaborative Study to Assess Molecular EGFR T790M Testing in Liquid Biopsy

, 2023
Background: The detection of the EGFR T790M (T790M) mutation in non-small cell lung cancer (NSCLC) patients who progressed under treatment with first- or second-generation EGFR-tyrosine kinase inhibitors (TKIs) is important to offer a subsequent therapy ...
Viktor Sebek, Herwig Zach, on behalf of the Liquid Biopsy Collaborative Study Group on behalf of the Liquid Biopsy Collaborative Study Group, Verena Kainz, Martin Filipits   +4 more
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Disruption of embryonic blood-CSF barrier in chick embryos reveals the actual importance of this barrier to control E-CSF composition and homeostasis in early brain development [PDF]

, 2013
In vertebrates, early brain development takes place at the expanded anterior end of the neural tube. After closure of the anterior neuropore, the brain wall forms a physiologically sealed cavity that encloses embryonic cerebrospinal fluid (E-CSF), a ...
Bueno i Torrens, David, 1965-, Parvas, Maryam   +1 more
core   +4 more sources

Liquid biopsy in CNS tumors: Current status & future perspectives

Indian Journal of Pathology and Microbiology, 2022
Precise classification of central nervous system (CNS) malignancies is vital for the treatment and prognostication. Identification of noninvasive markers can be of importance to guide treatment decisions and in monitoring treatment response.
Nuzhat Husain, Adil Husain, Sridhar Mishra, Pallavi Srivastava   +3 more
doaj   +1 more source

Liquid Biopsy of Cerebrospinal Fluid Enables Selective Profiling of Glioma Molecular Subtypes at First Clinical Presentation [PDF]

, 2023
Purpose: Current glioma diagnostic guidelines call for molecular profiling to stratify patients into prognostic and treatment sub-groups. In case the tumor tissue is inaccessible, cerebrospinal fluid (CSF) has been proposed as a reliable tumor DNA source
Santoro A., Indraccolo S., Comoglio P. M., Persico P., Boccaccio C., Giordano L., Crisafulli G., Lazzarini E., Melcarne A., Garbossa D., Gasparini A., Pessina F., Cassoni P., De Bacco F., Macagno M., Bono B., Dipasquale A., Zeppa P., Simonelli M., Barault L., Orzan F.   +20 more
core   +1 more source

Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations

Frontiers in Oncology, 2020
Background: The significance of uncommon epidermal growth factor receptor (EGFR) mutations in patients with non-small cell lung cancer (NSCLC) and brain metastasis (BM) remains unclear.
Chunhua Ma, Juncheng Zhang, Juncheng Zhang, Dongjiang Tang, Dongjiang Tang, Xin Ye, Xin Ye, Jing Li, Ning Mu, Zhi Li, Renzhong Liu, Liang Xiang, Liang Xiang, Chuoji Huang, Chuoji Huang, Rong Jiang   +15 more
doaj   +1 more source