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Cell-free DNA from cerebrospinal fluid cytology specimens as a novel liquid biopsy approach for pediatric patients with primary central nervous system tumors [PDF]

Acta Neuropathologica Communications
Background Assessing circulating cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) has been proposed as a promising alternative to tissue biopsy. Advances in cfDNA sequencing have further underscored the potential of CSF liquid biopsies in the clinical ...
Nicholas Chun +24 more
doaj +2 more sources

[Different Gene Mutation Spectrum of the Paired CSF and Plasma Samples in Lung Adenocarcinoma with Leptomeningeal Metastases: the Liquid Biopsy Based on Circulating Tumor DNA].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2020
Leptomeningeal metastasis (LM) are a severe complication of non-small cell lung cancer (NSCLC), and normally accompanied by poor prognosis. For the patients with targetable mutations, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are the preferred treatment, but the acquired TKI resistance is inextricable.
Huiying Li +4 more
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ID #1131 Predicting Early Tumor Progression in Patients with Atypical Teratoid/Rhabdoid Tumor with Longitudinal CSF Liquid Biopsies: A Report from Phase 2 Study (SJATRT) stratum B1.

Neuro-Oncology Pediatrics
Abstract Background Atypical teratoid/rhabdoid (AT/RT) is an aggressive pediatric brain tumor, prevalent in children < 3 years(Y) of age; methylation profiles subclassify AT/RTs into AT/RT-MYC (MYC), AT/RT-SHH (SHH), and AT/RT-TYR (TYR). At the molecular level, AT/RT shows alterations in
Aditi Bagchi +28 more
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Urine and cerebrospinal fluid biomarkers for early glioma detection: a systematic review [PDF]

Diagnostic and Prognostic Research
Background Liquid biopsies offer a minimally invasive approach for early glioma detection. However, potential non-blood biomarkers in urine and CSF are under-researched.
Craig Paterson +7 more
doaj +2 more sources

Role of Machine Learning in Liquid Biopsy of Brain Tumours [PDF]

Journal of the Pakistan Medical Association
Liquid biopsy has multiple benefits and is used extensively in other fields of oncology, but its role in neuro-oncology has been limited so far. Multiple tumour-derived materials like circulating tumour cells (CTCs), tumour-educated platelets (TEPs ...
Zanib Javed +3 more
doaj +2 more sources

GENE-41. LIQUID BIOPSY USING CELL FREE DNA FROM THE CEREBROSPINAL FLUID (CSF) IN GLIOMA [PDF]