Results 21 to 30 of about 1,649,172 (225)

P14.10.AMYD88L265P MUTATION IN THE DIAGNOSIS OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL): CORRELATION BETWEEN TUMOUR TISSUE AND CEREBROSPINAL FLUID (CSF) BY LIQUID BIOPSY [PDF]

Neuro-Oncology, 2023
Abstract BACKGROUND Primary Central Nervous System Lymphomas (PCNSLs) harbour MYD88L265P activating mutations in up to 70% of patients. Whether detection of MYD88L265P by liquid biopsy may be an accurate, non-invasive procedure for diagnosis and disease monitoring of PCNSL patients is a matter of ...
Francesco Bruno, Luca Bertero, Simone Ferrero, Federica Cavallo, Michele Clerico, Daniela Drandi, Martina Ferrante, Luca Mangherini, Alessia Andrea Ricci, Claudia Manini, Edoardo Pronello, Rosa Palmiero, Alessia Pellerino, Diego Garbossa, Riccardo Soffietti, Benedetto Bruno, Roberta Rudà   +16 more
openalex   +2 more sources

A Clinical Audit: Assessing the Diagnostic Delay of Primary Brain Tumors, Glioblastoma IDH-Wild Type and Primary CNS Lymphoma; Exploring the Use of CSF Liquid Biopsy

SVOA Neurology, 2023
Background: Diagnostic delay is a critical issue in healthcare, often leading to delayed treatment and poor patient outcomes. Diagnostic errors contribute to about 10% of patient deaths annually. Delays are very prevalent in Glioblastoma and Primary CNS Lymphoma.
Sana J. Ghosheh
openalex   +2 more sources

BIOM-12. LIQUID BIOPSIES IN CNS TUMORS: A COMBINED APPROACH TO PROFILING CSF

Neuro-Oncology
Abstract In precision medicine, molecular profiling of pediatric tumors is crucial for diagnosis, prognosis, and therapeutic decision-making. Traditional biopsy methods, often invasive, have inherent risks and may not capture a tumor’s heterogeneity. Liquid biopsy, however, offers a minimally invasive and comprehensive alternative.
Liana Nobre, Yoshiko Nakano, Ian Burns, Monique Johnson, Javal Sheth, Mansuba Rana, Richard Yuditskiy, Logine Negm, Michal Zápotocký, Ana Guerreiro Stücklin, Craig Erker, Chantel Cacciotti, Adam Fleming, Sylvia Cheng, Annie Huang, Andrew Bondoc, M Lim Fat, Anirban Das, Vanan Magimairajan, J Bennet, Robert Siddaway, Uri Tabori, Cynthia Hawkins   +22 more
openalex   +2 more sources

Tumor-derived cell-free DNA detected in cerebrospinal fluid enables minimally invasive profiling of pediatric brain tumors [PDF]

The Journal of Clinical Investigation
BACKGROUND Liquid biopsy has emerged as a minimally invasive method for tumor diagnosis, monitoring, and therapeutic guidance. For CNS tumors, cerebrospinal fluid (CSF) provides a reliable and accessible source of tumor-derived cell-free DNA (ctDNA ...
Liana Nobre, Yoshiko Nakano, Ian Burns, Robert Siddaway, Michal Zápotocky, Monique Johnson, Mansuba Rana, Cyril Li, Rodney K. Lyn, Richard Yuditskiy, Michelle Ku, Javal Sheth, Adrian B. Levine, Cody L. Nesvick, Anirban Das, Chantel Cacciotti, Shayna Zelcer, Seth A. Climans, Maria MacDonald, Logine Negm, Jiil Chung, Julie Bennett, Andrew Bondoc, Jim Loukides, Lucie Stengs, Melissa Edwards, Eric Bouffet, Vijay Ramaswamy, Anthony P.Y. Liu, Annie Huang, Ute Bartels, Peter B. Dirks, Uri Tabori, Cynthia Hawkins   +33 more
doaj   +2 more sources

Liquid biopsy in pediatric brain tumors [PDF]

Frontiers in Genetics, 2023
Malignant primary brain tumors are the most common cancer in children aged 0–14 years, and are the most common cause of death among pediatric cancer patients.
Arushi Tripathy, Vishal John, Jack Wadden, Seongbae Kong, Sana Sharba, Carl Koschmann   +5 more
doaj   +2 more sources

PATH-66. Double identity: molecular heterogeneity between liquid biopsy from the CSF and tissue samples of a multifocal, disseminated High-Grade Astrocytoma with Piloid Features (HGAP) in NF1 patient [PDF]

Neuro-Oncology
Abstract We describe a 46-year-old male with Neurofibromatosis type 1 (NF1) and a previously known parenchymal medullary mass identified in 2022, initially managed with surveillance. In late 2023, he developed a progressive brainstem syndrome prompting presentation to our center.
Khaled Dweik, Maciej M. Mrugała, Ehab Harahsheh, Kliment Donev, Jonathan B. Ashman, Bernard R. Bendok, Shannon P. Fortin Ensign   +6 more
openalex   +2 more sources

Decoding Brain Metastasis With Liquid Biopsy: Biomarkers and Technologies in EGFR‐Mutant NSCLC [PDF]

Cancer Medicine
Brain metastasis (BM) is a leading cause of cancer‐related mortality, particularly in patients with lung cancer. Traditional diagnostic methods, such as tissue biopsies, are often impractical, and there are currently no reliable biomarkers for early ...
Yuxiang Sun, Qinglin Wang, Pengcheng Zhu, Zhitong Li, Tongyan Liu, Rong Yin   +5 more
doaj   +2 more sources

GR.5 Establishing the utility of multi-platform liquid biopsy by integrating the CSF methylome and proteome in CNS malignancy [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Background: Liquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, the integration of multiple molecular platforms has yielded novel insights into disease biology and heterogeneity. We hypothesise that applying contemporary multi-omic approaches to liquid biopsies will improve the power of ...
AP Landry, Jeffrey Zuccato, V Patil, MR Voisin, JZ Wang, Yosef Ellenbogen, Chloe Gui, Andrew Ajisebutu, Farshad Nassiri, Gelareh Zadeh   +9 more
openalex   +2 more sources

BIOM-56. A FEASIBILITY STUDY UTILIZING SEQUENTIAL CEREBROSPINAL FLUID (CSF) - BASED LIQUID BIOPSY AND AMIDE PROTON TRANSFER (APT) MRI TO DIFFERENTIATE DISEASE PROGRESSION FROM RADIATION NECROSIS IN PATIENTS WITH BRAIN METASTASIS FROM SOLID TUMORS [PDF]

Neuro-Oncology
Abstract BACKGROUND Brain metastases affect 30–40% of patients with solid tumors, and as systemic therapies improve survival, intracranial recurrences are more common. Radiation therapy is standard of care treatment but can frequently lead to radiation necrosis, which can mimic tumor ...
Catarina Martins Maia, Shanshan Jiang, Carmen Kut, Victoria Croog, Susan C. Scott, Benjamin Levy, Mary Wilkinson, Jennifer Y. Sheng, Princess Mark-Adjeli, Cesar A. Santa‐Maria, David Kamson, Chetan Bettegowda, Solmaz Sahebjam   +12 more
openalex   +3 more sources

BIOM-02. DISSECTING CDK4/6 INHIBITOR RESISTANCE MECHANISMS IN RECURRENT PEDIATRIC BRAIN TUMORS WITH LONGITUDINAL CSF LIQUID BIOPSIES FROM THE SJDAWN CLINICAL TRIAL [PDF]

Neuro-Oncology
Abstract BACKGROUND SJDAWN (NCT03434262) is a St. Jude Children’s Research Hospital phase 1 trial that assessed the safety and benefit of CDK4/6 inhibitor-based therapy in patients with relapsed CNS tumors. To capture tumor evolution dynamics and arising resistance mechanisms in response to treatment,
Katie Han, Anna Kostecka, Kyle Smith, Sandeep Kumar Dhanda, Hong Lin, Margit Mikkelsen, Giles Robinson, Paul A. Northcott   +7 more
openalex   +2 more sources