Results 21 to 30 of about 1,761,915 (233)
Frontiers in Bioscience-Landmark, 2021 The molecular profiling of tumors is fundamental in the management of advanced non-small-cell lung cancer (NSCLC). A tissue specimen obtained from biopsy is needed for diagnosis and mutation analysis. However, this may not be feasible for some metastatic
Chi-Lu Chiang +3 more
doaj +1 more source
OS1.4 Liquid biopsy of the CSF in a series of GBM patients: preliminary results [PDF]
Neuro-Oncology, 2019 Abstract BACKGROUND Liquid biopsy (LB) by cerebrospinal fluid (CSF) can be useful to identify circulating tumour DNA (ctDNA), thus offering information about the heterogeneity of the neoplastic genome.
R Rudà +9 more
openaire +1 more source
P16.02.B DIAGNOSTIC ACCURACY OF CSF LIQUID BIOPSY AND MRI FOR LEPTOMENINGEAL METASTASES IN SOLID CANCERS: A META-ANALYSIS [PDF]
Neuro Oncol, 2023 Abstract BACKGROUND Leptomeningeal metastasis (LM) is a life-threatening and quickly advancing complication in patients with solid cancer. Reliable diagnosis is challenging. CSF cytology remains the standard diagnostic test for LM, though the sensitivity has been reportedly at un-satisfactory levels ...
Y Nakasu +6 more
europepmc +2 more sources
Diagnostics, 2021 Recent studies have suggested the feasibility of detecting H3K27M mutations in the cerebrospinal fluid of diffuse midline glioma (DMG) patients. However, cerebrospinal fluid from patients in these studies were collected mainly during biopsy, ventriculo ...
Jotaro On +11 more
doaj +1 more source
Beyond the Blood: CSF-Derived cfDNA for Diagnosis and Characterization of CNS Tumors
Frontiers in Cell and Developmental Biology, 2020 Genetic data are rapidly becoming part of tumor classification and are integral to prognosis and predicting response to therapy. Current molecular tumor profiling relies heavily on tissue resection or biopsy. Tissue profiling has several disadvantages in
Abbye E. McEwen +8 more
doaj +1 more source
, 2022 BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving
Chunhui Li (501186) +4 more
core +1 more source
Cerebrospinal Fluid biomarkers in pediatric brain tumors: A systematic review
Neoplasia: An International Journal for Oncology Research, 2023 Central nervous system (CNS) tumors are the leading cause of cancer death in pediatric patients. Though these tumors typically require invasive surgical procedures to diagnose, cerebrospinal fluid (CSF) liquid biopsy presents a potential method for rapid
Kurt R. Lehner +4 more
doaj +1 more source
, 2022 BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving
Chunhui Li (501186) +4 more
core +1 more source
Clinical Application of Liquid Biopsy In CNS Tumors With Reference To Exosomes And Mirna [PDF]
, 2023 In most cases, it is difficult to make an earlier diagnosis of the Central nervous system (CNS) tumour, which continues to be the most lethal cancer. Patients with chemo-resistance who completed their primary therapy are shown to later develop recurrent ...
Manish Tenguria, Vishal Rajput, Meenu Gupta, Neha Sharma, Sanjay Gupta
core +1 more source
Genome-wide methylation analysis of circulating tumor DNA: A new biomarker for recurrent glioblastom
Heliyon, 2023 Background: Glioblastoma (GBM) is a malignant tumor with a short survival and poor prognosis and a lack of clinically validated biomarkers for diagnosis and prognosis.
Lin Dai, Zhihui Liu, Yi Zhu, Lixin Ma
doaj +1 more source