Journal of Neuro-OncologyLiquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, it is increasingly recognized that multi-omic molecular approaches are a powerful avenue through which to understand complex and heterogeneous disease biology. We hypothesize that merging these two promising frontiers of cancer research
G Zadeh
exaly +3 more sources
Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors
Translational OncologyElena Pentsova
exaly
Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy. [PDF]
Theranostics, 2020 Background: In the era of precision medicine, cancer treatment is increasingly tailored according to tumor-specific genomic alterations. The analysis of tumor-derived circulating nucleic acids in cerebrospinal fluid (CSF) by next generation sequencing (NGS) may facilitate precision medicine in the field of CNS cancer. We therefore evaluated whether NGS
von Baumgarten L +14 more
europepmc +4 more sources
Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma [PDF]
Neurospine, 2023 Objective Although cerebrospinal fluid (CSF)-based liquid biopsy was proved to be practical in molecular analysis of intracranial gliomas, liquid biopsy of primary intramedullary astrocytoma was rarely reported.
Lei Cheng +9 more
doaj +3 more sources
Case Report: Concordance of cerebrospinal fluid-derived circulating tumor DNA with tumor tissue in spinal glioblastoma associated with Lynch syndrome [PDF]
Frontiers in OncologyBackgroundSpinal glioblastoma (GBM) is an exceptionally rare entity and poses significant diagnostic challenges due to a substantial risk of neurological morbidity with surgical biopsy. Tissue-based analyses are frequently limited by sampling constraints
Carlen A. Yuen +17 more
doaj +2 more sources
Cerebrospinal Fluid miRNA Profiling as a Potential Liquid Biopsy for Vestibular Schwannomas [PDF]
Non-Coding RNABackground/Objectives: This study aimed to identify a characteristic miRNA expression profile in the CSF of patients diagnosed with vestibular schwannoma and evaluate its potential for tumor assessment.
Małgorzata Litwiniuk-Kosmala +7 more
doaj +2 more sources
Liquid biopsy in pediatric brain tumors [PDF]
Frontiers in Genetics, 2023 Malignant primary brain tumors are the most common cancer in children aged 0–14 years, and are the most common cause of death among pediatric cancer patients.
Arushi Tripathy +5 more
doaj +2 more sources
Is liquid biopsy mature enough for the diagnosis of Alzheimer’s disease?
Frontiers in Aging Neuroscience, 2022 The preclinical diagnosis and clinical practice for Alzheimer’s disease (AD) based on liquid biopsy have made great progress in recent years. As liquid biopsy is a fast, low-cost, and easy way to get the phase of AD, continual efforts from intense ...
Xun Gong +9 more
doaj +3 more sources
Targeted liquid biopsy for brain tumors
The Journal of Liquid BiopsyCerebrospinal fluid (CSF) is a promising source of molecular biomarkers in the detection and monitoring of brain malignancies. Unlike peripheral blood, where biomarker detection is hindered by the blood-brain barrier and the complex nature of biofluids ...
Muhammad Izhar +3 more
doaj +2 more sources
Role of Machine Learning in Liquid Biopsy of Brain Tumours [PDF]
Journal of the Pakistan Medical AssociationLiquid biopsy has multiple benefits and is used extensively in other fields of oncology, but its role in neuro-oncology has been limited so far. Multiple tumour-derived materials like circulating tumour cells (CTCs), tumour-educated platelets (TEPs ...
Zanib Javed +3 more
doaj +2 more sources