Results 1 to 10 of about 10,378 (206)

Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy [PDF]

Theranostics, 2020
Background: In the era of precision medicine, cancer treatment is increasingly tailored according to tumor-specific genomic alterations. The analysis of tumor-derived circulating nucleic acids in cerebrospinal fluid (CSF) by next generation sequencing (NGS) may facilitate precision medicine in the field of CNS cancer. We therefore evaluated whether NGS
Andreas Jung, Louisa Von Baumgarten, Niklas Thon   +2 more
exaly   +4 more sources

Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma [PDF]

Neurospine, 2023
Objective Although cerebrospinal fluid (CSF)-based liquid biopsy was proved to be practical in molecular analysis of intracranial gliomas, liquid biopsy of primary intramedullary astrocytoma was rarely reported.
Lei Cheng, Wanru Duan, Jian Guan, Kai Wang, Zhenlei Liu, Xingwen Wang, Zuowei Wang, Hao Wu, Zan Chen, Fengzeng Jian   +9 more
doaj   +3 more sources

P16.02.B DIAGNOSTIC ACCURACY OF CSF LIQUID BIOPSY AND MRI FOR LEPTOMENINGEAL METASTASES IN SOLID CANCERS: A META-ANALYSIS [PDF]

Neuro Oncol, 2023
Abstract BACKGROUND Leptomeningeal metastasis (LM) is a life-threatening and quickly advancing complication in patients with solid cancer. Reliable diagnosis is challenging. CSF cytology remains the standard diagnostic test for LM, though the sensitivity has been reportedly at un-satisfactory levels ...
Y Nakasu, S Deguchi, S Nakasu, M Yamazaki, A Notsu, K Mitsuya, N Hayashi   +6 more
europepmc   +2 more sources

Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis

Frontiers in Oncology, 2022
BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving
Hanbin Wang, Hanbin Wang, Luxuan Wang, Chuan Fang, Chuan Fang, Chuan Fang, Chuan Fang, Chunhui Li, Chunhui Li, Lijian Zhang, Lijian Zhang, Lijian Zhang, Lijian Zhang   +12 more
doaj   +3 more sources

Is liquid biopsy mature enough for the diagnosis of Alzheimer’s disease?

Frontiers in Aging Neuroscience, 2022
The preclinical diagnosis and clinical practice for Alzheimer’s disease (AD) based on liquid biopsy have made great progress in recent years. As liquid biopsy is a fast, low-cost, and easy way to get the phase of AD, continual efforts from intense ...
Xun Gong, Hantao Zhang, Xiaoyan Liu, Yi Liu, Yi Liu, Junlin Liu, Funmilayo O. Fapohunda, Peng Lü, Kun Wang, Min Tang   +9 more
doaj   +3 more sources

Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine

Neuro-Oncology, 2022
AbstractBackgroundThe ability to identify genetic alterations in cancers is essential for precision medicine; however, surgical approaches to obtain brain tumor tissue are invasive. Profiling circulating tumor DNA (ctDNA) in liquid biopsies has emerged as a promising approach to avoid invasive procedures.
Gavin Ha, Justin Rhoades, Liliana Goumnerova   +2 more
exaly   +3 more sources

Decoding Brain Metastasis With Liquid Biopsy: Biomarkers and Technologies in EGFR‐Mutant NSCLC [PDF]

Cancer Medicine
Brain metastasis (BM) is a leading cause of cancer‐related mortality, particularly in patients with lung cancer. Traditional diagnostic methods, such as tissue biopsies, are often impractical, and there are currently no reliable biomarkers for early ...
Yuxiang Sun, Qinglin Wang, Pengcheng Zhu, Zhitong Li, Tongyan Liu, Rong Yin   +5 more
doaj   +2 more sources

Cell-free DNA from cerebrospinal fluid cytology specimens as a novel liquid biopsy approach for pediatric patients with primary central nervous system tumors [PDF]

Acta Neuropathologica Communications
Background Assessing circulating cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) has been proposed as a promising alternative to tissue biopsy. Advances in cfDNA sequencing have further underscored the potential of CSF liquid biopsies in the clinical ...
Nicholas Chun, Brandon Edelbach, Muhammad Baig, Laura A. T. Kagami, Richard A. Robison, Edwina Choung, Isaac Kremsky, Kevin Leeper, Brian Ferguson, D. Gigi Ostrow, Cindy Fong, Udochukwu Oyoyo, Rajeev Nowrangi, Minwoo Song, Bin Othman, Tanya Minasian, Diem Kieu Tran, Sujata Mushrif, Adina Achiriloaie, Saied Mirshahidi, Gary Yu, Pramil Singh, Ravi Raghavan, Jaclyn A. Biegel, Yan Chen Wongworawat   +24 more
doaj   +2 more sources

Urine and cerebrospinal fluid biomarkers for early glioma detection: a systematic review [PDF]

Diagnostic and Prognostic Research
Background Liquid biopsies offer a minimally invasive approach for early glioma detection. However, potential non-blood biomarkers in urine and CSF are under-researched.
Craig Paterson, Jinyue Yu, Philippa Davies, Jack Read, Jennifer C Palmer, Sarah Dawson, Julian PT Higgins, Kathreena M Kurian   +7 more
doaj   +2 more sources

METB-05. CSF LIQUID BIOPSY: PAVING THE WAY FOR MINIMALLY INVASIVE BRAIN TUMOR SURVEILLANCE USING LOW-PASS WHOLE GENOME SEQUENCING [PDF]

Neuro Oncol
Abstract OBJECTIVE We describe a clinical liquid biopsy platform for disease detection and surveillance in pediatric patients with primary central nervous system (CNS) tumors using low-pass whole genome sequencing (LP-WGS) on cell-free DNA (cfDNA) isolated from cerebrospinal fluid (CSF).
Tam, Lydia T, Rossi, Grace, Stevens, Jeff, Ronsley, Rebecca, Vitanza, Nicholas A, Cole, Bonnie L, Paulson, Vera A, Lockwood, Christina M, Leary, Sarah E S, Crotty, Erin E   +9 more
europepmc   +2 more sources