Results 1 to 10 of about 1,649,172 (225)

Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy. [PDF]

Theranostics, 2020
Background: In the era of precision medicine, cancer treatment is increasingly tailored according to tumor-specific genomic alterations. The analysis of tumor-derived circulating nucleic acids in cerebrospinal fluid (CSF) by next generation sequencing (NGS) may facilitate precision medicine in the field of CNS cancer. We therefore evaluated whether NGS
von Baumgarten L, Kumbrink J, Jung A, Reischer A, Flach M, Liebmann S, Metzeler KH, Holch JW, Niyazi M, Thon N, Straube A, von Bergwelt-Baildon M, Heinemann V, Kirchner T, Westphalen CB.   +14 more
europepmc   +6 more sources

Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma [PDF]

Neurospine, 2023
Objective Although cerebrospinal fluid (CSF)-based liquid biopsy was proved to be practical in molecular analysis of intracranial gliomas, liquid biopsy of primary intramedullary astrocytoma was rarely reported.
Lei Cheng, Wanru Duan, Jian Guan, Kai Wang, Zhenlei Liu, Xingwen Wang, Zuowei Wang, Hao Wu, Zan Chen, Fengzeng Jian   +9 more
doaj   +5 more sources

P16.02.B DIAGNOSTIC ACCURACY OF CSF LIQUID BIOPSY AND MRI FOR LEPTOMENINGEAL METASTASES IN SOLID CANCERS: A META-ANALYSIS [PDF]

Neuro Oncol, 2023
Abstract BACKGROUND Leptomeningeal metastasis (LM) is a life-threatening and quickly advancing complication in patients with solid cancer. Reliable diagnosis is challenging. CSF cytology remains the standard diagnostic test for LM, though the sensitivity has been reportedly at un-satisfactory levels ...
Yoko Nakasu, Shoichi Deguchi, Satoshi Nakasu, Mutsumi Yamazaki, Akiko Notsu, Koichi Mitsuya, Nobukazu Hayashi   +6 more
europepmc   +4 more sources

Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine [PDF]

Neuro-Oncology, 2022
AbstractBackgroundThe ability to identify genetic alterations in cancers is essential for precision medicine; however, surgical approaches to obtain brain tumor tissue are invasive. Profiling circulating tumor DNA (ctDNA) in liquid biopsies has emerged as a promising approach to avoid invasive procedures.
Gavin Ha, Justin Rhoades, Liliana Goumnerova   +2 more
exaly   +4 more sources

Establishing the utility of multi-platform liquid biopsy by integrating the CSF methylome and proteome in CNS tumours [PDF]

Journal of Neuro-Oncology
Liquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, it is increasingly recognized that multi-omic molecular approaches are a powerful avenue through which to understand complex and heterogeneous disease biology. We hypothesize that merging these two promising frontiers of cancer research
C Gui
exaly   +4 more sources

METB-05. CSF LIQUID BIOPSY: PAVING THE WAY FOR MINIMALLY INVASIVE BRAIN TUMOR SURVEILLANCE USING LOW-PASS WHOLE GENOME SEQUENCING [PDF]

Neuro Oncol
Abstract OBJECTIVE We describe a clinical liquid biopsy platform for disease detection and surveillance in pediatric patients with primary central nervous system (CNS) tumors using low-pass whole genome sequencing (LP-WGS) on cell-free DNA (cfDNA) isolated from cerebrospinal fluid (CSF).
Lydia Tam, Grace C. Rossi, Jeff Stevens, Rebecca Ronsley, Nicholas A. Vitanza, Bonnie Cole, Vera Paulson, Christina M. Lockwood, Sarah Leary, Erin Crotty   +9 more
europepmc   +4 more sources

Reply to “Improving Specificity of CSF Liquid Biopsy for Genetic Testing” [PDF]

Annals of Neurology, 2021
Stephanie Baulac, Jeong Ho Lee, Sara Baldassari   +2 more
exaly   +4 more sources

CSF Liquid Biopsy in High-Grade Gliomas: Identification of miRNA and Protein Biomarkers

Brain and Spine
Dr. Debora Giunti, Dr. Paolo Caldara, Dr. Elena Cerutti, Dr. Valeria Lusi, Dr. Daniele De Pasquale, Dr. Monica Truffelli, Dr. Andrea Petretto, Dr. Maurizio Bruschi, Dr. Mariella Dono, Gianluigi Zona, Pietro Fiaschi, Dr. Andrea Bianconi   +11 more
doaj   +3 more sources

Tapping into the genome: the role of CSF ctDNA liquid biopsy in glioma [PDF]

Neuro-Oncology Advances, 2022
Abstract Liquid biopsy has emerged as a novel noninvasive tool in cancer diagnostics. While significant strides have been made in other malignancies using liquid biopsy for diagnosis, disease monitoring, and treatment selection, development of these assays has been more challenging for brain tumors.
Joshua Friedman, Charli Ann J. Hertz, Matthias A. Karajannis, Alexandra Miller   +3 more
openalex   +3 more sources

Liquid biopsy for CNS lymphoma: CSF exosomes and CSF exosomal miR-15a, miR-21, miR-155, miR-210, and miR-19b are promising biomarkers for diagnosis

Molecular Biology Reports
Central nervous system lymphoma (CNSL) is a devastating disease with a poor prognosis. Early diagnosis, monitoring of the treatment response, and outcome prediction carry the utmost importance in the management of patients with CNSL. Surgical biopsy is the gold standard for tissue diagnosis, however, this procedure has potential complications ...
Sadaf Mahfooz, Mustafa Aziz Hatiboğlu, Håkan Seyithanoglu   +2 more
exaly   +5 more sources