Results 11 to 20 of about 1,649,172 (225)

Targeted liquid biopsy for brain tumors

The Journal of Liquid Biopsy
Cerebrospinal fluid (CSF) is a promising source of molecular biomarkers in the detection and monitoring of brain malignancies. Unlike peripheral blood, where biomarker detection is hindered by the blood-brain barrier and the complex nature of biofluids ...
Muhammad Izhar, Ziyad Ahmad, Manahil Moazzam, Arwa Jader   +3 more
doaj   +4 more sources

Integrating Radiogenomics and CSF-Based Liquid Biopsy Sequencing for Precision Neuro-Oncology. [PDF]

Int J Mol Sci
Glioblastoma and diffuse gliomas pose major therapeutic challenges due to marked intratumoral heterogeneity, limited tissue accessibility, and the blood–brain barrier. Tissue-based next-generation sequencing (NGS) remains essential for WHO CNS5 molecular
Kubiak K, Szurowska E.
europepmc   +3 more sources

JS08.6.A CSF DERIVED LIQUID BIOPSIES FOR GLIOMA DIAGNOSIS [PDF]

Neuro-Oncology, 2023
Abstract BACKGROUND Distinctive genetic changes can identify various types of gliomas. However, acquiring tumor material via surgery in the central nervous system (CNS) can pose the danger of neurological impairments, especially if the tumor is located near critical areas or in the brain stem. Gliomas
Florian Iser, Cenap Güngör, Jochen Meyer, L Dörner, L Hofmann, Niklas Graßl, Areeba Patel, Brigitte Wildemann, Michael Platten, Wolfgang Wick, Felix Sahm, Tobias Keßler   +11 more
openalex   +2 more sources

Incorporating CSF liquid biopsy into workflows for Autoimmune Encephalitis: A new diagnostic approach

Journal of the Neurological Sciences
Autoimmune encephalitis (AE) has become the primary framework for evaluating subacute neurological decline in emergency and hospitalized patients. The field's success in identifying antibody-mediated syndromes has been remarkable but that success has created a blind spot.
Jagannadha Avasarala
  +5 more sources

BIOM-40. MONITORING THERAPY IN LEPTOMENINGEAL CARCINOMATOSIS IN COLORECTAL CANCER USING CSF LIQUID BIOPSY [PDF]

Neuro-Oncology
Abstract Leptomeningeal carcinomatosis (LC) in colorectal cancer implies poor prognosis. However, there is little information on the efficacy of systemic or intrathecal therapy for this disease. Liquid biopsy (LBx) as performed using CSF is emerging as a reliable tool for the diagnosis and monitoring of patients with LC.
Maher Albitar, Ahmad Charifa, Sally Agersborg, Adam Albitar, William Hoos, P.M. Kasi, Michael Cusnir, Santosh Kesari   +7 more
openalex   +3 more sources

OS1.4 Liquid biopsy of the CSF in a series of GBM patients: preliminary results [PDF]

Neuro-Oncology, 2019
Abstract BACKGROUND Liquid biopsy (LB) by cerebrospinal fluid (CSF) can be useful to identify circulating tumour DNA (ctDNA), thus offering information about the heterogeneity of the neoplastic genome.
Roberta Rudà, Francesco Bruno, Francesca De Bacco, Francesca Orzan, Paola Cassoni, Roberto Altieri, Antonio Melcarne, Diego Garbossa, Carla Boccaccio, Riccardo Soffietti   +9 more
openalex   +2 more sources

BIOM-68. TAPS LIQUID BIOPSY: AN ULTRASENSITIVE, INTEGRATED GENOMIC-EPIGENETIC CSF ASSAY FOR CNS TUMORS [PDF]

Neuro-Oncology
Abstract Liquid biopsy of cerebrospinal fluid (CSF)-derived circulating tumor DNA (ctDNA) has been shown to be a feasible and low-risk alternative to tissue sampling for patients with central nervous system (CNS) tumors. The implementation of CSF ctDNA liquid biopsy has proven challenging due to the molecular diversity of CNS diseases.
Camila Fang, Eloise Freitag, Alexander Araya Oviedo, Chanel Schroff, Kevin Hadi, Aditya Deshpande, Johnathan Rafailov, Hannah Weiss, Neha Dhasmana, Stergios Zacharoulis, Daniel A. Orringer, Yiying Yang, Kazimierz O. Wrzeszczyński, Marcin Imieliński, Matija Snuderl, Alexandra Miller   +15 more
openalex   +2 more sources

ID #729 LBSeq4Kids clinical liquid biopsy platform demonstrates a high detection rate in CSF at diagnosis and facilitates sequential CSF monitoring for high-risk pediatric brain tumors [PDF]

Neuro-Oncology Pediatrics
Abstract The LBSeqKids clinically validated liquid biopsy platform combines low passage whole genome sequencing (LP-WGS) to detect copy number alterations (CNAs) and a 136 gene targeted sequencing panel (TSP) to detect mutations in cerebrospinal fluid (CSF), aqueous humor of the eye and plasma in patients with solid tumors.
Tom Rosenberg, Laura Kagami, Katrina O’ Halloran, Erin White, Jacquelyn Jones, Susan Chi, JA Biegel   +6 more
openalex   +2 more sources

Blood, CSF, and Urine Biomarkers for Paediatric Brain Tumours: A Systematic Review of Liquid Biopsy Approaches

Neuro-Oncology Pediatrics
Abstract Background Identification of non-invasive biomarkers in blood, cerebrospinal fluid (CSF), or urine could aid diagnosis and monitoring in paediatric brain tumours. Methods We searched MEDLINE, Embase, SCIE ...
Jack Read, Jinyue Yu, C. Paterson, Farhad Shokraneh, Phillipa Davies, Julian P T Higgins, Kathreena M. Kurian   +6 more
openalex   +2 more sources

Is liquid biopsy mature enough for the diagnosis of Alzheimer’s disease?

Frontiers in Aging Neuroscience, 2022
The preclinical diagnosis and clinical practice for Alzheimer’s disease (AD) based on liquid biopsy have made great progress in recent years. As liquid biopsy is a fast, low-cost, and easy way to get the phase of AD, continual efforts from intense ...
Xun Gong, Hantao Zhang, Xiaoyan Liu, Yi Liu, Yi Liu, Junlin Liu, Funmilayo O. Fapohunda, Peng Lü, Kun Wang, Min Tang   +9 more
doaj   +3 more sources