Results 11 to 20 of about 1,761,915 (233)

Tumor-derived cell-free DNA detected in cerebrospinal fluid enables minimally invasive profiling of pediatric brain tumors [PDF]

The Journal of Clinical Investigation
BACKGROUND Liquid biopsy has emerged as a minimally invasive method for tumor diagnosis, monitoring, and therapeutic guidance. For CNS tumors, cerebrospinal fluid (CSF) provides a reliable and accessible source of tumor-derived cell-free DNA (ctDNA ...
Liana Nobre, Yoshiko Nakano, Ian Burns, Robert Siddaway, Michal Zápotocky, Monique Johnson, Mansuba Rana, Cyril Li, Rodney K. Lyn, Richard Yuditskiy, Michelle Ku, Javal Sheth, Adrian B. Levine, Cody L. Nesvick, Anirban Das, Chantel Cacciotti, Shayna Zelcer, Seth A. Climans, Maria MacDonald, Logine Negm, Jiil Chung, Julie Bennett, Andrew Bondoc, Jim Loukides, Lucie Stengs, Melissa Edwards, Eric Bouffet, Vijay Ramaswamy, Anthony P.Y. Liu, Annie Huang, Ute Bartels, Peter B. Dirks, Uri Tabori, Cynthia Hawkins   +33 more
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MRD4U: A path to development for personalized liquid biopsy for children with central nervous system tumors

BMC Cancer
Background Liquid biopsy assays using cerebrospinal fluid (CSF) can revolutionize care for children with central nervous system (CNS) tumors by enabling precise monitoring of therapeutic responses and detecting recurrence or measurable residual disease ...
Anthony R. Miller, Tithi Shah, Corinne N. Strawser, Adithe Rivaldi, Sarah A. Wilson, Huachun Zhong, Jocelyn M. Lucyshyn, Elizabeth AR Garfinkle, Makenna McCoy, Seth Cummins, Alejandro Otero Bravo, Peter Chang, Gregory L. Wheeler, David M. Gordon, Benjamin J. Kelly, Caitlyn Evanovich, Samara L. Potter, Elizabeth A. Varga, Diana P. Rodriguez, Richard K. Wilson, Catherine E. Cottrell, Ralph Salloum, Sara Khan, Maryam Fouladi, Elaine R. Mardis, Margot A. Lazow, Katherine E. Miller   +26 more
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Utility of cerebrospinal fluid liquid biopsy in distinguishing CNS lymphoma from cerebrospinal infectious/demyelinating diseases

Cancer Medicine, 2023
Background Distinguishing between central nervous system lymphoma (CNSL) and CNS infectious and/or demyelinating diseases, although clinically important, is sometimes difficult even using imaging strategies and conventional cerebrospinal fluid (CSF ...
Chisako Iriyama, Kenichiro Murate, Sachiko Iba, Akinao Okamoto, Naoe Goto, Hideyuki Yamamoto, Toshiharu Kato, Keichiro Mihara, Takahiko Miyama, Keiko Hattori, Ryoko Kajiya, Masataka Okamoto, Yasuaki Mizutani, Seiji Yamada, Tetsuya Tsukamoto, Yuichi Hirose, Tatsuro Mutoh, Hirohisa Watanabe, Akihiro Tomita   +18 more
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Decoding Brain Metastasis With Liquid Biopsy: Biomarkers and Technologies in EGFR‐Mutant NSCLC [PDF]

Cancer Medicine
Brain metastasis (BM) is a leading cause of cancer‐related mortality, particularly in patients with lung cancer. Traditional diagnostic methods, such as tissue biopsies, are often impractical, and there are currently no reliable biomarkers for early ...
Yuxiang Sun, Qinglin Wang, Pengcheng Zhu, Zhitong Li, Tongyan Liu, Rong Yin   +5 more
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Cell-free DNA from cerebrospinal fluid cytology specimens as a novel liquid biopsy approach for pediatric patients with primary central nervous system tumors

Acta Neuropathologica Communications
Background Assessing circulating cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) has been proposed as a promising alternative to tissue biopsy. Advances in cfDNA sequencing have further underscored the potential of CSF liquid biopsies in the clinical ...
Nicholas Chun, Brandon Edelbach, Muhammad Baig, Laura A. T. Kagami, Richard A. Robison, Edwina Choung, Isaac Kremsky, Kevin Leeper, Brian Ferguson, D. Gigi Ostrow, Cindy Fong, Udochukwu Oyoyo, Rajeev Nowrangi, Minwoo Song, Bin Othman, Tanya Minasian, Diem Kieu Tran, Sujata Mushrif, Adina Achiriloaie, Saied Mirshahidi, Gary Yu, Pramil Singh, Ravi Raghavan, Jaclyn A. Biegel, Yan Chen Wongworawat   +24 more
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Urine and cerebrospinal fluid biomarkers for early glioma detection: a systematic review [PDF]

Diagnostic and Prognostic Research
Background Liquid biopsies offer a minimally invasive approach for early glioma detection. However, potential non-blood biomarkers in urine and CSF are under-researched.
Craig Paterson, Jinyue Yu, Philippa Davies, Jack Read, Jennifer C Palmer, Sarah Dawson, Julian PT Higgins, Kathreena M Kurian   +7 more
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CSF Liquid Biopsy in High-Grade Gliomas: Identification of miRNA and Protein Biomarkers

Brain and Spine
Dr. Debora Giunti, Dr. Paolo Caldara, Dr. Elena Cerutti, Dr. Valeria Lusi, Dr. Daniele De Pasquale, Dr. Monica Truffelli, Dr. Andrea Petretto, Dr. Maurizio Bruschi, Dr. Mariella Dono, Gianluigi Zona, Pietro Fiaschi, Dr. Andrea Bianconi   +11 more
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Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis

Frontiers in Oncology, 2022
BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving
Hanbin Wang, Hanbin Wang, Luxuan Wang, Chuan Fang, Chuan Fang, Chuan Fang, Chuan Fang, Chunhui Li, Chunhui Li, Lijian Zhang, Lijian Zhang, Lijian Zhang, Lijian Zhang   +12 more
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Tapping into the genome: the role of CSF ctDNA liquid biopsy in glioma

Neuro-Oncology Advances, 2022
Abstract Liquid biopsy has emerged as a novel noninvasive tool in cancer diagnostics. While significant strides have been made in other malignancies using liquid biopsy for diagnosis, disease monitoring, and treatment selection, development of these assays has been more challenging for brain tumors.
Friedman, Joshua S, Hertz, Charli Ann J, Karajannis, Matthias A, Miller, Alexandra M   +3 more
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Unique Genomic Alterations of Cerebrospinal Fluid Cell-Free DNA Are Critical for Targeted Therapy of Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

Frontiers in Oncology, 2021
We reported unique molecular features of cerebrospinal fluid (CSF) of nonsmall cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM), suggesting establishing CSF as a better liquid biopsy in clinical practices.
Yongsheng Wang, Feng Jiang, Ruixue Xia, Ming Li, Chengyun Yao, Yan Li, Hui Li, Qi Zhao, Mingke Shi, Yanzhe Yu, Yang W. Shao, Guoren Zhou, Hongping Xia, Liyun Miao, Hourong Cai   +14 more
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