Results 11 to 20 of about 10,378 (206)

Liquid biopsy in pediatric brain tumors [PDF]

Frontiers in Genetics, 2023
Malignant primary brain tumors are the most common cancer in children aged 0–14 years, and are the most common cause of death among pediatric cancer patients.
Arushi Tripathy, Vishal John, Jack Wadden, Seongbae Kong, Sana Sharba, Carl Koschmann   +5 more
doaj   +3 more sources

Targeted liquid biopsy for brain tumors [PDF]

The Journal of Liquid Biopsy
Cerebrospinal fluid (CSF) is a promising source of molecular biomarkers in the detection and monitoring of brain malignancies. Unlike peripheral blood, where biomarker detection is hindered by the blood-brain barrier and the complex nature of biofluids ...
Muhammad Izhar, Ziyad Ahmad, Manahil Moazzam, Arwa Jader   +3 more
doaj   +2 more sources

Role of Machine Learning in Liquid Biopsy of Brain Tumours [PDF]

Journal of the Pakistan Medical Association
Liquid biopsy has multiple benefits and is used extensively in other fields of oncology, but its role in neuro-oncology has been limited so far. Multiple tumour-derived materials like circulating tumour cells (CTCs), tumour-educated platelets (TEPs ...
Zanib Javed, Saqib Kamran Bakhshi, Saad Akhtar Khan, Muhammad Shahzad Shamim   +3 more
doaj   +3 more sources

Utility of cerebrospinal fluid liquid biopsy in distinguishing CNS lymphoma from cerebrospinal infectious/demyelinating diseases [PDF]

Cancer Medicine, 2023
Background Distinguishing between central nervous system lymphoma (CNSL) and CNS infectious and/or demyelinating diseases, although clinically important, is sometimes difficult even using imaging strategies and conventional cerebrospinal fluid (CSF ...
Chisako Iriyama, Kenichiro Murate, Sachiko Iba, Akinao Okamoto, Naoe Goto, Hideyuki Yamamoto, Toshiharu Kato, Keichiro Mihara, Takahiko Miyama, Keiko Hattori, Ryoko Kajiya, Masataka Okamoto, Yasuaki Mizutani, Seiji Yamada, Tetsuya Tsukamoto, Yuichi Hirose, Tatsuro Mutoh, Hirohisa Watanabe, Akihiro Tomita   +18 more
doaj   +2 more sources

MRD4U: A path to development for personalized liquid biopsy for children with central nervous system tumors [PDF]

BMC Cancer
Background Liquid biopsy assays using cerebrospinal fluid (CSF) can revolutionize care for children with central nervous system (CNS) tumors by enabling precise monitoring of therapeutic responses and detecting recurrence or measurable residual disease ...
Anthony R. Miller, Tithi Shah, Corinne N. Strawser, Adithe Rivaldi, Sarah A. Wilson, Huachun Zhong, Jocelyn M. Lucyshyn, Elizabeth AR Garfinkle, Makenna McCoy, Seth Cummins, Alejandro Otero Bravo, Peter Chang, Gregory L. Wheeler, David M. Gordon, Benjamin J. Kelly, Caitlyn Evanovich, Samara L. Potter, Elizabeth A. Varga, Diana P. Rodriguez, Richard K. Wilson, Catherine E. Cottrell, Ralph Salloum, Sara Khan, Maryam Fouladi, Elaine R. Mardis, Margot A. Lazow, Katherine E. Miller   +26 more
doaj   +2 more sources

Low Detection Rate of H3K27M Mutations in Cerebrospinal Fluid Obtained from Lumbar Puncture in Newly Diagnosed Diffuse Midline Gliomas [PDF]

Diagnostics, 2021
Recent studies have suggested the feasibility of detecting H3K27M mutations in the cerebrospinal fluid of diffuse midline glioma (DMG) patients. However, cerebrospinal fluid from patients in these studies were collected mainly during biopsy, ventriculo ...
Jotaro On, Manabu Natsumeda, Jun Watanabe, Shoji Saito, Yu Kanemaru, Hideaki Abe, Yoshihiro Tsukamoto, Masayasu Okada, Makoto Oishi, Junichi Yoshimura, Akiyoshi Kakita, Yukihiko Fujii   +11 more
doaj   +2 more sources

Liquid biopsy for cancer management: a revolutionary but still limited new tool for precision medicine [PDF]

Advances in Laboratory Medicine, 2020
The term liquid biopsy is used in contraposition to the traditional “solid” tissue biopsy. In the oncology field it has opened a new plethora of clinical opportunities as tumor-derived material is shedded into the different biofluids from where it can be
Arechederra María, Ávila Matías A., Berasain Carmen   +2 more
doaj   +2 more sources

Establishing the utility of multi-platform liquid biopsy by integrating the CSF methylome and proteome in CNS tumours

Journal of Neuro-Oncology
Liquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, it is increasingly recognized that multi-omic molecular approaches are a powerful avenue through which to understand complex and heterogeneous disease biology. We hypothesize that merging these two promising frontiers of cancer research
Landry, A. P., Zuccato, J. A., Patil, V., Voisin, M. R., Wang, J. Z., Ellenbogen, Y., Gui, C., Ajisebutu, A., Kislinger, T., Nassiri, F., Zadeh, G.   +10 more
exaly   +3 more sources

Chromatin accessibility derived from cfDNA serves as a novel classification biomarker of glioma [PDF]

Frontiers in Oncology
IntroductionGliomas can be classified by their molecular characteristics, which are also closely associated with clinical outcomes. Cell-free DNA (cfDNA)-based liquid biopsy in gliomas is challenging because of the limited amount of tumor-derived cfDNA ...
Qiuyue Wu, Jian Wu, Fan Wang, Qiang Wang, Wei Dai, Yang Yang, Chuanyue Zhang, Ying Han, Min Chen, Hao Pan, Lan Luo, Xinyi Xia, Xinyi Xia, Xinyi Xia   +13 more
doaj   +2 more sources

Analysis of cerebrospinal fluid tumor-derived DNA to obviate biopsy of IDH-mutant brainstem glioma in an adult [PDF]

The Journal of Liquid Biopsy
Adult brainstem gliomas are rare and present unique diagnostic and therapeutic challenges due to their critical location and limited biopsy feasibility. Molecular profiling of tumor-derived DNA (t-DNA) isolated from cerebrospinal fluid (CSF) is emerging ...
Michael Youssef, Alexandra Larson, Vindhya Udhane, Kala F. Schilter, Qian Nie, Honey V. Reddi   +5 more
doaj   +2 more sources