Results 41 to 50 of about 1,649,172 (225)

Disruption of embryonic blood-CSF barrier in chick embryos reveals the actual importance of this barrier to control E-CSF composition and homeostasis in early brain development [PDF]

, 2013
In vertebrates, early brain development takes place at the expanded anterior end of the neural tube. After closure of the anterior neuropore, the brain wall forms a physiologically sealed cavity that encloses embryonic cerebrospinal fluid (E-CSF), a ...
Bueno i Torrens, David, 1965-, Parvas, Maryam   +1 more
core   +6 more sources

Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis

Frontiers in Oncology, 2022
BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving
Hanbin Wang, Hanbin Wang, Luxuan Wang, Chuan Fang, Chuan Fang, Chuan Fang, Chuan Fang, Chunhui Li, Chunhui Li, Lijian Zhang, Lijian Zhang, Lijian Zhang, Lijian Zhang   +12 more
doaj   +1 more source

Unique Genomic Alterations of Cerebrospinal Fluid Cell-Free DNA Are Critical for Targeted Therapy of Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

Frontiers in Oncology, 2021
We reported unique molecular features of cerebrospinal fluid (CSF) of nonsmall cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM), suggesting establishing CSF as a better liquid biopsy in clinical practices.
Yongsheng Wang, Feng Jiang, Ruixue Xia, Ming Li, Chengyun Yao, Yan Li, Hui Li, Qi Zhao, Mingke Shi, Yanzhe Yu, Yang W. Shao, Guoren Zhou, Hongping Xia, Liyun Miao, Hourong Cai   +14 more
doaj   +1 more source

682P CSF liquid biopsy as an innovative tool for research on patients with leptomeningeal metastasis and pediatric brain tumors

Annals of Oncology
Giancarlo Feliciello, Cäcilia Köstler, Kathrin Weidele, Florian Lüke, Miodrag Gužvić, Marcel Jakob, Saida Zoubaa, Adithi R. Varadarajan, Xin Lü, Hong Qu, Jan Martin Proske, Thomas Schamberger, Zbigniew T. Czyż, Jens Warfsmann, Peter Hau, Selim Corbacioglu, Markus J. Riemenschneider, Tobias Pukrop, Christoph A. Klein, Bernhard Polzer   +19 more
openalex   +2 more sources

Cerebrospinal fluid as a medium of liquid biopsy in the management of patients with non-small-cell lung cancer having central nervous system metastasis

Frontiers in Bioscience-Landmark, 2021
The molecular profiling of tumors is fundamental in the management of advanced non-small-cell lung cancer (NSCLC). A tissue specimen obtained from biopsy is needed for diagnosis and mutation analysis. However, this may not be feasible for some metastatic
Chi-Lu Chiang, Hsu-Ching Huang, Yung-Hung Luo, Chao-Hua Chiu   +3 more
doaj   +1 more source

Low Detection Rate of H3K27M Mutations in Cerebrospinal Fluid Obtained from Lumbar Puncture in Newly Diagnosed Diffuse Midline Gliomas

Diagnostics, 2021
Recent studies have suggested the feasibility of detecting H3K27M mutations in the cerebrospinal fluid of diffuse midline glioma (DMG) patients. However, cerebrospinal fluid from patients in these studies were collected mainly during biopsy, ventriculo ...
Jotaro On, Manabu Natsumeda, Jun Watanabe, Shoji Saito, Yu Kanemaru, Hideaki Abe, Yoshihiro Tsukamoto, Masayasu Okada, Makoto Oishi, Junichi Yoshimura, Akiyoshi Kakita, Yukihiko Fujii   +11 more
doaj   +1 more source

Beyond the Blood: CSF-Derived cfDNA for Diagnosis and Characterization of CNS Tumors

Frontiers in Cell and Developmental Biology, 2020
Genetic data are rapidly becoming part of tumor classification and are integral to prognosis and predicting response to therapy. Current molecular tumor profiling relies heavily on tissue resection or biopsy. Tissue profiling has several disadvantages in
Abbye E. McEwen, Abbye E. McEwen, Abbye E. McEwen, Sarah E. S. Leary, Sarah E. S. Leary, Sarah E. S. Leary, Sarah E. S. Leary, Christina M. Lockwood, Christina M. Lockwood   +8 more
doaj   +1 more source

Cerebrospinal Fluid biomarkers in pediatric brain tumors: A systematic review

Neoplasia: An International Journal for Oncology Research, 2023
Central nervous system (CNS) tumors are the leading cause of cancer death in pediatric patients. Though these tumors typically require invasive surgical procedures to diagnose, cerebrospinal fluid (CSF) liquid biopsy presents a potential method for rapid
Kurt R. Lehner, Kelly Jiang, Jordina Rincon-Torroella, Ranjan Perera, Chetan Bettegowda   +4 more
doaj   +1 more source

Genome-wide methylation analysis of circulating tumor DNA: A new biomarker for recurrent glioblastom

Heliyon, 2023
Background: Glioblastoma (GBM) is a malignant tumor with a short survival and poor prognosis and a lack of clinically validated biomarkers for diagnosis and prognosis.
Lin Dai, Zhihui Liu, Yi Zhu, Lixin Ma
doaj   +1 more source

Cerebrospinal fluid circulating tumor DNA depicts profiling of brain metastasis in NSCLC

Molecular Oncology, 2023
Brain metastasis (BM) genetically diverges from the primary tumor in non‐small‐cell lung cancer (NSCLC). Hence, accurately capturing clinically relevant alterations is pivotal for the delivery of targeted therapies.
Jun Wu, Zhiqiang Liu, Tianxiang Huang, Ying Wang, Meng Meng Song, Tao Song, Gretchen Long, Xiaobing Zhang, Xi Li, Longbo Zhang   +9 more
doaj   +1 more source