The Clinical Applications of Liquid Biopsies in Pediatric Brain Tumors: A Systematic Literature Review [PDF]
, 2022 SIMPLE SUMMARY: Brain tumors are the most common solid cancer in children and are traditionally diagnosed via a tissue biopsy or resection. Liquid biopsy offers the possibility to characterize brain tumors based on their circulating DNA in blood ...
Raphael Guzman +7 more
core +1 more source
Liquid biopsy in CNS tumors: Current status & future perspectives
Indian Journal of Pathology and Microbiology, 2022 Precise classification of central nervous system (CNS) malignancies is vital for the treatment and prognostication. Identification of noninvasive markers can be of importance to guide treatment decisions and in monitoring treatment response.
Nuzhat Husain +3 more
doaj +1 more source
Liquid biopsy for children with central nervous system tumours: Clinical integration and technical considerations. [PDF]
, 2023 Circulating cell-free DNA (cfDNA) analysis has the potential to revolutionise the care of patients with cancer and is already moving towards standard of care in some adult malignancies.
Hubank, M +5 more
core +1 more source
Clinical Application of Liquid Biopsy In CNS Tumors With Reference To Exosomes And Mirna [PDF]
, 2023 In most cases, it is difficult to make an earlier diagnosis of the Central nervous system (CNS) tumour, which continues to be the most lethal cancer. Patients with chemo-resistance who completed their primary therapy are shown to later develop recurrent ...
Manish Tenguria, Vishal Rajput, Meenu Gupta, Neha Sharma, Sanjay Gupta
core +1 more source
CSF liquid biopsy in patients with difusse glioma. Systematic review [PDF]
, 2023 Curs 2022-2023Background: Diffuse gliomas are the most common primary tumors in the central nervous system, with a low survival rate. Tumor biopsy is the current method to demonstrate them, but it carries risks and does not always represent all the ...
Sainz Vecino, Patricia Eliana
core
Diagnostic accuracy of cerebrospinal fluid liquid biopsy and MRI for leptomeningeal metastases in solid cancers : A systematic review and meta-analysis [PDF]
, 2023 Background: Cerebrospinal fluid (CSF) cytology remains the gold standard approach for diagnosing of leptomeningeal metastases (LM), but has clinical problems due to its low sensitivity.
NOTSU, Akifumi +14 more
core +1 more source
Frontiers in Oncology, 2020 Background: The significance of uncommon epidermal growth factor receptor (EGFR) mutations in patients with non-small cell lung cancer (NSCLC) and brain metastasis (BM) remains unclear.
Chunhua Ma +15 more
doaj +1 more source
Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review [PDF]
Background: The utility of liquid biopsies is well documented in several extracranial and intracranial (brain/leptomeningeal metastases, gliomas) tumors.Methods: The RANO (Response Assessment in Neuro-Oncology) group has set up a multidisciplinary Task ...
Rubenstein, James L +18 more
core +6 more sources
Detection of IDH mutations in cerebrospinal fluid: A discussion of liquid biopsy in neuropathology [PDF]
, 2020 Isocitrate dehydrogenase (IDH) mutations are a common event in secondary glioblastoma multiforme and lower-grade adult infiltrative astrocytomas and independently confer a better prognosis [1,2].
Ming Lee* +3 more
core +1 more source
Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screening [PDF]
, 2023 Advance Access date 9 February 2023Background. Brain cancer is the leading cause of cancer-related death in children. Early detection and serial monitoring are essential for better therapeutic outcomes.
Jordan R Hansford +21 more
core +1 more source