Results 61 to 70 of about 1,649,172 (225)

Liquid biopsy from research to clinical practice : focus on non-small cell lung cancer

, 2021
: Introduction In the current era of personalized medicine, liquid biopsy has acquired a relevant importance in patient management of advanced stage non-small cell lung cancer (NSCLC).
Pisapia, Pasquale, De Miguel-Perez, Diego, Nuzzo, Pier Vitale, Addeo, Alfredo, Jantus-Lewintre, Eloisa, Rolfo, Christian, Bellosillo, Beatriz, Serrano, Maria Jose, Malapelle, Umberto, Arrieta, Oscar, Cardona, Andres F., Denninghoff, Valeria, Pauwels, Patrick, Troncone, Giancarlo, Raez, Luis E., Gandara, David R., Duran, Ignacio, Pickering, Edward M., Russo, Alessandro, Cristofanilli, Massimo, O'Byrne, Ken   +20 more
core  

Image_1_Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis.jpeg

, 2022
BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving
Chunhui Li (501186), Lijian Zhang (387002), Hanbin Wang (1556056), Luxuan Wang (14276447), Chuan Fang (11911301)   +4 more
core   +1 more source

Image_2_Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis.jpeg

, 2022
BackgroundBrain metastases (BM) include brain parenchymal (BPM) and leptomeningeal metastases (LM), which are associated with a poor prognosis and high mortality rate. Early and accurate diagnosis and timely, effective treatment are crucial for improving
Chunhui Li (501186), Lijian Zhang (387002), Hanbin Wang (1556056), Luxuan Wang (14276447), Chuan Fang (11911301)   +4 more
core   +1 more source

Utility of cerebrospinal fluid liquid biopsy in distinguishing CNS lymphoma from cerebrospinal infectious/demyelinating diseases

Cancer Medicine, 2023
Background Distinguishing between central nervous system lymphoma (CNSL) and CNS infectious and/or demyelinating diseases, although clinically important, is sometimes difficult even using imaging strategies and conventional cerebrospinal fluid (CSF ...
Chisako Iriyama, Kenichiro Murate, Sachiko Iba, Akinao Okamoto, Naoe Goto, Hideyuki Yamamoto, Toshiharu Kato, Keichiro Mihara, Takahiko Miyama, Keiko Hattori, Ryoko Kajiya, Masataka Okamoto, Yasuaki Mizutani, Seiji Yamada, Tetsuya Tsukamoto, Yuichi Hirose, Tatsuro Mutoh, Hirohisa Watanabe, Akihiro Tomita   +18 more
doaj   +1 more source

Case Report: Concordance of cerebrospinal fluid-derived circulating tumor DNA with tumor tissue in spinal glioblastoma associated with Lynch syndrome

Frontiers in Oncology
BackgroundSpinal glioblastoma (GBM) is an exceptionally rare entity and poses significant diagnostic challenges due to a substantial risk of neurological morbidity with surgical biopsy. Tissue-based analyses are frequently limited by sampling constraints
Carlen A. Yuen, Carlen A. Yuen, David O. Kamson, David O. Kamson, Changrui Xiao, William H. Yong, Jennifer E. Soun, Mark Linskey, Mark Linskey, Michelle Paff, Michelle Paff, Caressa Hui, Caressa Hui, Alexander M. Lopez, Alexander M. Lopez, Yael Freiberg, Hansen Bow, Hansen Bow   +17 more
doaj   +1 more source

3D-printed device for DNA fragmentation prior liquid biopsy testing [PDF]

, 2023
Direct detection of DNA in complex biological samples relates to several problems regarding the selectivity and sensitivity of analyses. Therefore, DNA pre-extraction from biofluids is an emerging tool in biologically related fields.
Marek, Minárik, František, Foret, Helena, Hrušková, Roman, Řemínek   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Cerebrospinal fluid: A unique source of circulating tumor DNA with broad clinical applications

Translational Oncology, 2023
Malignancies involving the central nervous system present unique challenges for diagnosis and monitoring due to the difficulties and risks of direct biopsies and the low specificity and/or sensitivity of other techniques for assessment.
Richard A. Hickman, Alexandra M. Miller, Maria E. Arcila   +2 more
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source