Results 151 to 160 of about 135,797 (305)

CTC detection in RCC patients

, 2018
Detection of CTC in patients with renal cell ...
Menglin Bai
core   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

DualCascadeTSF-MobileNetV2: A Lightweight Violence Behavior Recognition Model

Applied Sciences
This paper proposes a lightweight violent behavior recognition model, DualCascadeTSF-MobileNetV2, which is improved based on the temporal shift module and its subsequent research.
Yuang Chen, Yong Li, Shaohua Li, Shuhan Lv, Fang Lin   +4 more
doaj   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single-Cell Level in CTCs From HR+/HER2- Metastatic Breast Cancer. [PDF]

Cancer Sci
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Rossi T, Palleschi M, Gianni C, Merloni F, Virga A, Bandini S, Angeli D, Tebaldi M, Maltoni R, Ulivi P, Musolino A.   +10 more
europepmc   +2 more sources

Independent validation of the CTC-predictive profile on 49 early-stage lymph-node negative breast cancer patients.

, 2012
(A)Distribution of CTC-profile indexes for CTC-positive and CTC-negative patients. The dashed line indicates the threshold as was determined in the training cohort. (B) Validation ROC curve showing classification performance of the CTC-profile.
Paul Roepman (68450), Timothy J. Molloy (181855), Laura J. van't Veer (181864), Bjørn Naume (72631)   +3 more
core   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Liquid biopsy across cancers: Integrating circulating biomarkers, tumor biology, artificial intelligence, and clinical translation

Interdisciplinary Medicine, EarlyView.
Liquid biopsy uses non‐invasive sampling of blood or body fluids to isolate circulating analytes, including circulating tumor DNA, circulating tumor cells, extracellular vesicles, and RNA. These are analyzed using next‐generation sequencing, qPCR, and proteomics to inform cancer detection, monitoring, and characterization. Figure created with BioRender.
Jaswinder Singh, Manjeet Kumar, Kajal Kamra   +2 more
wiley   +1 more source

Redox‐Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations

Journal of Applied Toxicology, EarlyView.
ABSTRACT Dexamethasone (DEX) is widely used in clinical practice, although it may also cause oxidative stress–related damage in different tissues, including the kidney and male reproductive system. This study investigated DEX‐induced renal and reproductive injury in rats and evaluated the modulatory effect of reduced glutathione on DEX‐associated redox
Caner Öztürk, Neşe Hayat Aksoy, Erkan Özkan, Ayşe Ikinci Keleş, Ahmet Karabulut   +4 more
wiley   +1 more source

A Novel Application of the Volumetric Absorptive Micro Sampling Strategy to Quantify Dexmedetomidine in Capillary Blood Using an LC–MS/MS Method

Journal of Clinical Laboratory Analysis, EarlyView.
This study introduces a novel application of MITRA devices for collecting capillary blood to quantify dexmedetomidine using a newly developed and validated LC–MS/MS method. The highly sensitive developed method was successfully applied to analyze patient whole blood samples.
Lorena Lucatello, Martina Franzin, Gabriele Stocco, Jenny Bua, Francesca Cossovel, Riccardo Addobbati, Francesca Capolongo   +6 more
wiley   +1 more source

Trajectory of irritability in children and youth in Ontario, Canada, throughout the COVID‐19 pandemic

JCPP Advances, EarlyView.
This study explored how irritability in children and youth changed during the COVID‐19 pandemic and its impact on mental health. Results showed a gradual decline in irritability, with factors like age, parental anxiety, and resilience influencing its trajectory.
Theodore C. K. Cheung, Katherine T. Cost, Ronda F. Lo, Evdokia Anagnostou, Catherine S. Birken, Alice Charach, Suneeta Monga, Elizabeth Kelley, Rob Nicolson, Paul D. Arnold, Christie Burton, Daphne J. Korczak, Jennifer Crosbie   +12 more
wiley   +1 more source