Results 161 to 170 of about 3,671 (212)
Brain Pathology, EarlyView.Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma +12 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
Cancer Science, EarlyView.Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Tania Rossi +10 more
wiley +1 more source
Cell Proliferation, EarlyView.Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li +6 more
wiley +1 more source
Socioeconomic status, environmental factors, and motor function in children with cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.Abstract Aim To investigate the association between socioeconomic status and cerebral palsy (CP) motor function, adjusting for known clinical and candidate environmental risk factors, that is, air pollution and distance to a children's treatment center (CTC).
Hana F Alazem +14 more
wiley +1 more source
Ecological Entomology, EarlyView.Hamiltonella defensa infection increases honeydew production in certain aphid genotypes, potentially modifying aphid feeding behaviour. Parasitoid wasps, Aphidius ervi, are more attracted to honeydew from H. defensa‐infected aphids; though larger honeydew amounts may slightly deter searching.
Desiré Macheda +5 more
wiley +1 more source
Poverty Over the Life Course: Evidence From Birth to Emerging Adulthood
Family Relations, EarlyView.ABSTRACT Objective To assess if childhood poverty predicts poverty in emerging adulthood and identify the mechanisms. Background Early‐life poverty elevates the risk of adult economic disadvantage, but the specific pathways require clearer delineation.
Chien‐Chung Huang, Hui‐Fen Lin
wiley +1 more source
The FEBS Journal, EarlyView.Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero +8 more
wiley +1 more source
Long‐Term Institutional Investors and Executive Compensation
Financial Review, EarlyView.ABSTRACT Standard agency theory views would suggest that long‐term investors will use long‐term CEO compensation to align incentives and promote long‐term value maximization. An alternative view is that long‐term investors—who are more able to bear the fixed costs associated with monitoring—will monitor more heavily than short‐term investors, reducing ...
T. Colin Campbell +2 more
wiley +1 more source
Hepatology Research, EarlyView.We carried out proteomic analysis of serum extracellular vesicles to identify biomarkers predictive of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B receiving nucleos(t)ide analog therapy. Candidate proteins identified through proteomic analysis were subsequently quantified in serum by ELISA.
Emi Sometani +21 more
wiley +1 more source