Results 161 to 170 of about 127,497 (313)

Assessing the Estimands and Estimates of Hospitalization Rates in Health Economics and Clinical Medicine

open access: yesHealth Economics, EarlyView.
ABSTRACT Even though data on hospital admissions are widely used in health research, hospitalization‐related estimands measured using these data are not always clearly conceptualized. Consequently, estimators of these quantities can have unclear rationales and undesirable properties.
Aditya Jain   +7 more
wiley   +1 more source

Integrating Immunotherapy Into Head and Neck Surgery: Bridging Tumor Biology to Perioperative Decision‐Making, a Review

open access: yesHead &Neck, EarlyView.
ABSTRACT Objective To provide a comprehensive review of the biological rationale, clinical evidence, and practical perioperative management of immunotherapy for the head and neck surgeon. Summary Background Data Standard treatment for resectable head and neck squamous cell carcinoma (HNSCC) has reached a survival plateau, with over 50% of patients ...
Nicholas Brian Shannon, Bruce Ashford
wiley   +1 more source

CTC [PDF]

open access: yes, 2019
openaire   +1 more source

A Serum lncRNA Signature Determines Oncogenic YAP Activity in Cancer Patients

open access: yesInternational Journal of Cancer, EarlyView.
Long non‐coding RNAs (lncRNAs) signatures are promising cancer biomarkers, since their dysregulation in tumors is reflected in body fluids. In this study, next‐generation sequencing, bioinformatics, and gene expression data were combined to investigate an lncRNA signature linked specifically to the cancer‐promoting YAP in several cancer types ...
Fabian Rose   +24 more
wiley   +1 more source

Inverse association between obesity and intestinal endometriosis: Findings from a cross‐sectional study

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study evaluates the association between obesity and the presence of bowel endometriosis in patients undergoing surgery. Methods A retrospective cross‐sectional observational study was conducted with patients treated between September 2023 and December 2024, at a specialized endometriosis outpatient clinic of a tertiary hospital ...
Tereza Carolina Fonseca Corrêa   +1 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

open access: yesiNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid   +4 more
wiley   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

open access: yesInterdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang   +22 more
wiley   +1 more source

Redox‐Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Dexamethasone (DEX) is widely used in clinical practice, although it may also cause oxidative stress–related damage in different tissues, including the kidney and male reproductive system. This study investigated DEX‐induced renal and reproductive injury in rats and evaluated the modulatory effect of reduced glutathione on DEX‐associated redox
Caner Öztürk   +4 more
wiley   +1 more source

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