Results 121 to 130 of about 47,434 (363)

Essential Updates 2023/2024: Recent Advances of Multimodal Approach in Patients for Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Gastric cancer remains a major global health burden, especially in East Asia. Recent years have brought significant advances in multimodal management, including surgery, perioperative chemotherapy, immunotherapy, and supportive care. This review summarizes key updates from 2023 to 2024, focusing on surgical innovations, perioperative systemic ...
Katsutoshi Shoda, Yoshihiko Kawaguchi, Suguru Maruyama, Daisuke Ichikawa   +3 more
wiley   +1 more source

High fragmentation characterizes tumour-derived circulating DNA. [PDF]

PLoS ONE, 2011
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including colorectal cancer, especially when considering the detection of mutations.
Florent Mouliere, Bruno Robert, Erika Arnau Peyrotte, Maguy Del Rio, Marc Ychou, Franck Molina, Celine Gongora, Alain R Thierry   +7 more
doaj   +1 more source

Efficacy, Safety, and Biomarkers of Neoadjuvant Dalpiciclib (CDK4/6 inhibitor) plus Aromatase Inhibitors in Operable HER2-Negative Luminal B Breast Cancer: A Prospective, Single-Center, Single-Arm, Phase II Trial (DANCER). [PDF]

MedComm (2020)
DANCER (NCT05640778) was a circulating tumor DNA (ctDNA)‐directed, single‐arm, phase II trial investigating the clinical activity of dalpiciclib combined with aromatase inhibitors as a neoadjuvant regimen for operable human epidermal growth factor receptor 2 (HER2)‐negative luminal B breast cancer. Although a high complete cell cycle arrest (CCCA) rate
Zhou Y, Zhang Z, Chen H, Huang F, Shen L, Tao S, Qian W, Hong H, Pan C, Wang Z, Zhang J, Hu Y, Shen Y, Fu J, Mao W, Wu S, Guo X, Wang H, Ma M, Ma T, Pan L, Chen Y.   +21 more
europepmc   +2 more sources

Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors. [PDF]

, 2018
BACKGROUND: Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in advanced-
Al-Saadi, Reem, Brok, Jesper, Butcher, Robert, Chagtai, Tasnim, Cresswell, George D, Luscombe, Nicholas M, Mifsud, William, Pritchard Jones, Kathy, Roberts, Chrissy, Treger, Taryn D, Williams, Richard D   +10 more
core   +2 more sources

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

Nature Reviews Clinical Oncology, 2020
An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area of research, the Colon and Rectal–Anal Task Forces of the United States ...
A. Dasari, V. Morris, C. Allegra, C. Atreya, A. Benson, P. Boland, Ki Chung, M. Copur, R. Corcoran, D. Deming, A. Dwyer, M. Diehn, C. Eng, T. George, M. Gollub, R. Goodwin, Stanley R. Hamilton, J. Hechtman, H. Hochster, T. Hong, F. Innocenti, A. Iqbal, S. Jacobs, H. Kennecke, James J. Lee, C. Lieu, H. Lenz, O. Lindwasser, C. Montagut, B. Odisio, F. Ou, Laura D. Porter, K. Raghav, D. Schrag, A. Scott, Q. Shi, J. Strickler, A. Venook, R. Yaeger, G. Yothers, Y. You, J. Zell, S. Kopetz   +42 more
semanticscholar   +1 more source

Integrating Immune Checkpoint Inhibitors With Total Neoadjuvant Therapy in Proficient Mismatch Repair Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
The key to unlocking ICI benefit in pMMR/MSS LARC is to convert “cold” tumors into “hot” ones through lymphocyte‐sparing SCRT and judicious chemotherapy, creating a milieu in which ICIs can act effectively. ABSTRACT The management of locally advanced rectal cancer (LARC) has evolved with the adoption of total neoadjuvant therapy (TNT), integrated ...
Yoshinori Kagawa, Jun Watanabe, Koji Ando, Caleah Kitchens, Aron Bercz, J. Joshua Smith   +5 more
wiley   +1 more source

Circulating tumor DNA and magnetic resonance imaging to predict neoadjuvant chemotherapy response and recurrence risk

npj Breast Cancer, 2021
We investigated whether serial measurements of circulating tumor DNA (ctDNA) and functional tumor volume (FTV) by magnetic resonance imaging (MRI) can be combined to improve prediction of pathologic complete response (pCR) and estimation of recurrence ...
Mark Jesus M. Magbanua, Wen Li, Denise M. Wolf, Christina Yau, Gillian L. Hirst, Lamorna Brown Swigart, David C. Newitt, Jessica Gibbs, Amy L. Delson, Ekaterina Kalashnikova, Alexey Aleshin, Bernhard Zimmermann, A. Jo Chien, Debu Tripathy, Laura Esserman, Nola Hylton, Laura van ‘t Veer   +16 more
doaj   +1 more source

Outcomes of Resected Cases of Pancreatic Ductal Adenocarcinoma Patients With Unexpected Postoperative Uncovering Noncurative Factors: A Multicenter Retrospective Study

Annals of Gastroenterological Surgery, EarlyView.
We aimed to refine treatment strategies for resected cases of pancreatic ductal adenocarcinoma in patients with unexpectedly uncovered postoperative noncurative factors. Cases with unexpected postoperative uncovering noncurative factors had significantly poorer prognoses than those without such factors.
Hiroto Matsui, Naoki Ikenaga, Masafumi Nakamura, Takaaki Tatsuguchi, Shingo Kozono, Hirohisa Okabe, Hiromitsu Hayashi, Tomohiko Adachi, Susumu Eguchi, Kazuaki Hashimoto, Toru Hisaka, Takao Ide, Hirokazu Noshiro, Teijiro Hirashita, Atsushi Miyoshi, Atsushi Nanashima, Masatoshi Kajiwara, Tomoharu Yoshizumi, Yasuhisa Mori, Hiroaki Nagano, Kyushu Study Group of Treatment for Pancreatobilliary Cancer   +20 more
wiley   +1 more source

Significance of Serum Tumor Markers in Esophageal and Gastric Cancers: A Systematic Literature Review

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Serum tumor markers are helpful for diagnosis, monitoring treatment outcomes, and prognosis. However, their clinical utility for esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC) remains unclear. This study aimed to comprehensively evaluate recent studies on serum tumor markers in ESCC and GC.
Yasunori Matsumoto, Takeshi Toyozumi, Hideaki Shimada   +2 more
wiley   +1 more source

Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival. [PDF]

, 2019
PurposeGenomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with colorectal cancers were correlated with clinical outcomes.Patients and methodsNext-generation sequencing of ctDNA (54- to 73-gene panel) was performed in 94 ...
Fanta, Paul T, Kato, Shumei, Kurzrock, Razelle, Lanman, Richard B, Leichman, Lawrence, Lippman, Scott M, Okamura, Ryosuke, Raymond, Victoria M, Schwaederlé, Maria C, Talasaz, AmirAli   +9 more
core   +1 more source