Results 121 to 130 of about 39,021 (326)

Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients

BMC Cancer, 2018
Background Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is
Ashleigh C. McEvoy, Lydia Warburton, Zeyad Al-Ogaili, Liesl Celliers, Leslie Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Melanie Ziman, Elin S. Gray   +10 more
doaj   +1 more source

Impact of cytological sampling on EGFR mutation testing in stage III-IV lung adenocarcinoma [PDF]

, 2017
Objectives. There have been advances in the identification and understanding of molecular subsets of lung cancer, defined by specific oncogenic aberrations.
Butler, Rachel, Davies, Rhian Siân, Edwards, Gwenllian, Lester, Jason Francis, Parry, Diane, Smith, Christian   +5 more
core   +3 more sources

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Effect of DNA input on analytical and clinical parameters of a circulating tumor DNA assay for comprehensive genomic profiling

Journal of Laboratory Medicine
Circulating tumor DNA (ctDNA) assays play an increasingly important role in cancer management. A new version of TruSight Oncology 500 (TSO500) ctDNA, v2, was recently released, and the recommended DNA input was decreased to 20 ng from 30 ng in the prior ...
Lee Cheonghwa, Ha Changhee, Kim Young-gon, Kim Jong-Won   +3 more
doaj   +1 more source

Digital PCR analysis of circulating tumor DNA: a biomarker for chondrosarcoma diagnosis, prognostication, and residual disease detection [PDF]

, 2017
Conventional chondrosarcoma is the most common primary bone tumor in adults. Prognosis corresponds with tumor grade but remains variable, especially for individuals with grade (G) II disease.
Amary, F, Archard, N, Bi, M, Brown, J, Flanagan, AM, Forshew, T, Gibbons, R, Gupta, M, Gutteridge, A, J Davies, KE, O'Donnell, P, Pillay, N, Plagnol, V, Rathbone, VM, Tirabosco, R   +14 more
core   +1 more source

414P Landscape of ERBB2 mutations in advanced cancers (AC) using circulating tumor DNA (ctDNA) next-generation sequencing (NGS) in Asia and Middle East (AME) [PDF]

, 2023
B.C. Cho, Shaheenah Dawood, Talia Golan, N. Sandhir, S. Hsing   +4 more
openalex   +1 more source

Molecular crosstalk via exosomes in lung cancer progression

Interdisciplinary Medicine, EarlyView.
“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan   +3 more
wiley   +1 more source

Exploratory Analysis of $\textit{TP53}$ Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study [PDF]

, 2016
$\textbf{Background:}$ Circulating tumour DNA (ctDNA) carrying tumour-specific sequence alterations may provide a minimally invasive means to dynamically assess tumour burden and response to treatment in cancer patients. Somatic $\textit{TP53}$ mutations
Addley, H, Biggs, H, Brenton, JD, Earl, HM, Freeman, S, Gale, D, Gounaris, I, Hodgkin, C, Hosking, K, Jimenez-Linan, M, Moyle, P, Parkinson, CA, Piskorz, AM, Qian, W, Rosenfeld, N, Sala, E, Sayal, K   +16 more
core   +2 more sources

Lymph‐based liquid biopsy: Current progress and future potential

Interdisciplinary Medicine, EarlyView.
Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo   +6 more
wiley   +1 more source

Circulating tumor DNA (ctDNA) Detection via electrochemical Biosensing Tools

MANAS: Journal of Engineering
Cancer is characterized by the presence of mutated alleles in DNA, leading to the formation of tumors. A delayed diagnosis of this condition can result in fatal outcomes, making it a significant global cause of mortality.
Sonya Sahin, Nimet Yıldırım Tirgil
doaj   +1 more source