Results 151 to 160 of about 47,434 (363)

Tumor burden monitoring using cell-free tumor DNA could be limited by tumor heterogeneity in advanced breast cancer and should be evaluated together with radiographic imaging [PDF]

, 2017
BACKGROUND: Accurate measurement of tumor burden in breast cancer disease is essential to improve the clinical management of patients. In this study, we evaluate whether the fluctuations in the fraction of PIK3CA mutant allele correlates with tumor ...
Atocha Romero, Daniel Acosta-Eyzaguirre, Eduardo Díaz-Rubio, Fernando Moreno, José Angel García-Saenz, Julián Sanz, Marion Laig, Marta García-Esquinas, Miguel Barquín, Myriam Montes, Patricia Ayllón, Trinidad Caldes, Vanesa Garcia-Barberan   +12 more
core   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a)pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers [PDF]

, 2018
Introduction: Aqueous Tinospora cordifolia stem extract (Aq.Tc) and arabinogalactan (AG), its bioactive polysaccharide, which are antioxidant remedies were evaluated on pulmonary cancer and associated tumor markers.
Koul, Ashwani, Mohan, Vandana
core   +2 more sources

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto, Sophie Gibert, Caroline Delmas, David Tougeron, Amaury Paumier, Alexandre Taillez, Samuel Le Sourd, Delphine Argo Leignel, Philippe Ronchin, Ariane Darut Jouve, Véronique Vendrely, Olivier Riou, Jérôme Martin‐Babau, Thomas Leroy, Laurent Quéro, Naïma Hanoun, Pierre Cordelier, Veronica Pezzella, Jean Pierre Delord, Rosine Guimbaud, Elizabeth Moyal, Catherine Seva   +21 more
wiley   +1 more source

Circulating tumor DNA (ctDNA) Detection via electrochemical Biosensing Tools

MANAS: Journal of Engineering
Cancer is characterized by the presence of mutated alleles in DNA, leading to the formation of tumors. A delayed diagnosis of this condition can result in fatal outcomes, making it a significant global cause of mortality.
Sonya Sahin, Nimet Yıldırım Tirgil
doaj   +1 more source

Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients

BMC Cancer, 2018
Background Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is
Ashleigh C. McEvoy, Lydia Warburton, Zeyad Al-Ogaili, Liesl Celliers, Leslie Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Melanie Ziman, Elin S. Gray   +10 more
doaj   +1 more source

Adjuvant FLOT provides survival benefit for oesophagogastric junction and gastric adenocarcinoma patients with low tumour regression after neoadjuvant chemotherapy

International Journal of Cancer, EarlyView.
What's New? Perioperative FLOT, a chemotherapy regimen consisting of docetaxel, oxaliplatin, leucovorin and 5‐fluorouracil, is the standard treatment for oesophagogastric junction and gastric adenocarcinoma (OGA). Whether patients benefit further from adjuvant FLOT, given postoperatively, is uncertain.
Max Kraemer, Naita M. Wirsik, Hakan Alakus, Hans A. Schloesser, Hans Fuchs, Wolfgang Schroeder, Christiane J. Bruns, Su Ir Lyu, Friederike Baehr, Thomas Zander, Alexander Quaas   +10 more
wiley   +1 more source

Integrating ctDNA testing for EGFR analysis in advanced non-small cell lung cancer: strategies for clinical laboratories

Advances in Laboratory Medicine
Epidermal growth factor receptor gene (EGFR) molecular testing is essential for guiding targeted therapies in patients with advanced non-small cell lung cancer (NSCLC). Between 15 and 40 % of patients with NSCLC carry mutations in EGFR that are sensitive
Fernández-Galán Esther, Puig-Butillé Joan Anton   +1 more
doaj   +1 more source

Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine [PDF]

, 2018
Approximately one-half of advanced (unresectable or metastatic) melanomas harbor a mutation in the BRAF gene, with V600E being the most common mutation.
Cheng, Liang, Lopez-Beltran, Antonio, MacLennan, Gregory T., Massari, Francesco, Montironi, Rodolfo   +4 more
core   +1 more source

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, EarlyView.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source