Results 241 to 250 of about 94,347 (282)

Targeting the osteosarcoma immune microenvironment for improved immunotherapy and translational applications. [PDF]

Discov Oncol
Cai J, Qiu S, Sun B, Ge J, Yu Z, Wang C.
europepmc   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, Volume 13, Issue 8, 9 February 2026.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Combinatorial Analysis of CD4⁺Tregs, CD8⁺Teffs, and Inflammatory Indices Predict Response to ICI in ES-SCLC Patients. [PDF]

Cancers (Basel)
Xagara A, Tsapakidis K, Papadopoulos V, Kokkalis A, Chantzara E, Aidarinis C, Lazarou A, Christodoulopoulos G, Perifanou-Sotiri M, Verveniotis D, Rammou V, Vlachou MS, Kallergi G, Markou A, Samaras I, Koinis F, Saloustros E, Kotsakis A.   +17 more
europepmc   +1 more source

Global, Population and Genetic Evidence on the Relationships Between Immune‐Mediated Inflammatory Disease and Cancer Risk

Cancer Innovation, Volume 5, Issue 1, February 2026.
Using a triangulation framework that synthesizes findings across global, population and genetic perspectives, this work comprehensively establishes associations between six immune‐mediated inflammatory diseases (IMIDs) and 33 cancers, identifying 170 statistically significant IMID‐cancer pairs, validating 20 in the UKBB cohort and uncovering a causal ...
Xuesi Dong, Jiaxin Xie, Zilin Luo, Hao Hong, Chenran Wang, Yadi Zheng, Xiaoyue Shi, Zeming Guo, Xiaolu Chen, Yongjie Xu, Wei Cao, Fei Wang, Dong Hang, Sipeng Shen, Fengwei Tan, Ni Li   +15 more
wiley   +1 more source

Flow Cytometric Profiling of Peripheral Immune Checkpoints Predicts Prognosis and Reveals PD-1/Treg/IL-10 Crosstalk in B-Cell Lymphoma. [PDF]

Immunotargets Ther
Pan B, Li S, Ye R, Zhu J, Tang Y, Li L.
europepmc   +1 more source

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

Autoantibodies as predictors for immune-related adverse events in checkpoint inhibition therapy of metastatic melanoma. [PDF]

J Immunother Cancer
Reschke R, Budde P, Zucht HD, Mangana J, Dummer R, Pfoehler C, Wistuba-Hamprecht K, Weide B, Hakim-Meibodi LE, Meier F, Schulz C, Richter J, Bräutigam M, Gutjahr C, Schulz-Knappe P, Hassel JC.   +15 more
europepmc   +1 more source

Effectiveness and Mechanism of Cryoablation in the Treatment of Oral Mucosal Melanoma

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Objectives To assess the effectiveness and safety of cryoablation for oral mucosal melanoma (OMM) and explore its underlying mechanisms to provide insights for precision treatment of OMM. Materials and Methods Patients diagnosed with OMM were divided into a cryoablation group and a noncryoablation therapy group.
Zhu You, Tianqi Zhang, Li Dai, Jie Wen, Mingyang Liu, Tengda Zhao, Guozhu Yin, Yihua Wu, Shizhou Zhang   +8 more
wiley   +1 more source

Proteostasis of immune checkpoint receptors. [PDF]

Biochem J
Tey PY, Urbé S, Clague MJ.
europepmc   +1 more source