Results 51 to 60 of about 1,567 (165)

Molecular characterization of CTNS mutations in Tunisian patients with ocular cystinosis

Diagnostic Pathology, 2022
Background Ocular cystinosis is a rare autosomal recessive disorder characterized by intralysosomal cystine accumulation in renal, ophthalmic (cornea, conjunctiva), and other organ abnormalities.
Latifa Chkioua, Yessine Amri, Chaima Saheli, Wassila Mili, Sameh Mabrouk, Imen Chabchoub, Hela Boudabous, Wissem Ben Azzouz, Hadhami Ben Turkia, Salima Ferchichi, Neji Tebib, Taieb Massoud, Mohamed Ghorbel, Sandrine Laradi   +13 more
doaj   +1 more source

Genetic organisation, mobility and predicted functions of genes on integrated, mobile genetic elements in sequenced strains of Clostridium difficile.

PLoS ONE, 2011
BackgroundClostridium difficile is the leading cause of hospital-associated diarrhoea in the US and Europe. Recently the incidence of C. difficile-associated disease has risen dramatically and concomitantly with the emergence of 'hypervirulent' strains ...
Michael S M Brouwer, Philip J Warburton, Adam P Roberts, Peter Mullany, Elaine Allan   +4 more
doaj   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells

Frontiers in Endocrinology, 2019
Cystinosis is a lysosomal storage disorder caused by defects in CTNS, the gene that encodes the lysosomal cystine transporter cystinosin. Patients with nephropathic cystinosis are characterized by endocrine defects, defective proximal tubule cell (PTC ...
Jinzhong Zhang, Jing He, Jennifer L. Johnson, Farhana Rahman, Evripidis Gavathiotis, Ana Maria Cuervo, Sergio D. Catz   +6 more
doaj   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Accelerated Flowering and Differential Florigen Gene Expression of Seagrass Zostera marina Under Experimental Warming

Ecology and Evolution, Volume 16, Issue 1, January 2026.
Flowering is an important trait for the resilience of seagrasses. Using a native seagrass, Zostera marina, we applied a common garden approach to experimentally test how flowering and its underlying molecular mechanisms responded to elevated water temperature (+3°C).
Christine T. Nolan, Ian T. McBride, Niyah Reid, Sylvia Yang, Takato Imaizumi, Jennifer L. Ruesink, Jeffrey L. Gaeckle   +6 more
wiley   +1 more source

METTL1‐Mediated N7‐Methylguanosine tRNA Modification Alleviates Cardiac Ischemia/Reperfusion Injury by Modulating Mitochondrial Energy Metabolism

MedComm, Volume 7, Issue 1, January 2026.
During cardiac I/R injury, the level of METTL1 and tRNA m7G modification increases and then leads to CMs’ mitochondrial dysfunction and aggravated cardiac injury by modulating the transcription efficiency of ATPIF1. ABSTRACT Ischemic heart disease is one of the diseases with the highest morbidity and mortality in the world. The N7‐methylguanosine (m7G)
Yue Zhang, Mingyang Leng, Ruonan Wang, Xinyuan Tang, Zhenlu Cai, Liang Wang, Xiaoqi Shao, Hongtao Diao, Qinqiang Long, Xu Li, Yingzi Wu, Yuan Jiang, Haifeng Zhang, Haihai Liang, Jiao Guo   +14 more
wiley   +1 more source

Reimagining Early‐Phase Clinical Development in Japan: From Regulatory Obligation to Global Acceleration

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Japan has faced persistent challenges of “Drug Lag” and “Drug Loss”, partly due to the regulatory requirement for Japanese Phase I studies prior to global trial participation. However, recent regulatory reforms have introduced flexibility, creating new opportunities for Japan to strategically contribute to global drug development.
Yasunori Kawakita, Kayoko Matsumoto, Masaru Hirano, Satoru Inoue, Okishi Mashita, Hiroki Tawara, Mika Sato   +6 more
wiley   +1 more source

Advancements in Carbon‐Based Piezoelectric Materials: Mechanism, Classification, and Applications in Energy Science

Advanced Materials, Volume 37, Issue 48, December 3, 2025.
Carbon‐based piezoelectric materials are systematically categorized based on their structural and functional properties. The mechanisms of stress‐induced charge transfer are elucidated, and their applications are explored across three key domains: piezoelectric catalysis for energy conversion and environmental remediation, piezoelectric biomedical ...
Mude Zhu, Qingyou Liu, Wai‐Yeung Wong, Linli Xu   +3 more
wiley   +1 more source

Early diagnostic value of novel biomarkers for breast cancer therapy‐related cardiac dysfunction

ESC Heart Failure, Volume 12, Issue 6, Page 4194-4207, December 2025.
Our meta‐analysis revealed significant post‐treatment increases in GDF‐15, CRP, MPO, and PLGF levels (Gal‐3 unchanged) among breast cancer patients. Only elevated MPO levels were significantly associated with an increased risk of cancer therapy‐related cardiac dysfunction (CTRCD).
Zhengwei Wang, Yujuan Wu, Jingyi He, Diansa Gao, Zhong Zuo   +4 more
wiley   +1 more source