Results 161 to 170 of about 9,957 (210)

CuAAC: An Efficient Click Chemistry Reaction on Solid Phase

ACS Combinatorial Science, 2015
Click chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), to bind two molecular building blocks. CuAAC has broad applications in medicinal chemistry and other fields of chemistry.
Vida, Castro, Hortensia, Rodríguez, Fernando, Albericio   +2 more
openaire   +3 more sources

Sulfonyl-PYBOX Ligands Enable Kinetic Resolution of α-Tertiary Azides by CuAAC.

Angewandte Chemie, 2023
We report the first highly selective kinetic resolution of racemic α-chiral azides via Cu-catalyzed azide-alkyne cycloaddition (CuAAC). Newly developed pyridine-bisoxazoline (PYBOX) ligands bearing a C4 sulfonyl group enable effective kinetic resolution ...
Yi Gong, Cai-Ming Wang, F. Zhou, Kui Liao, Xi-Yu Wang, Ying Sun, Yan-xue Zhang, Zhi Tu, Xin Wang, Jian Zhou   +9 more
semanticscholar   +1 more source

Copper-Mediated Intramolecular Interrupted CuAAC Selanylation

The Journal of Organic Chemistry, 2023
We, herein, describe a copper-mediated domino CuAAC intramolecular selanylation for the synthesis of unprecedented fused benzo[4,5][1,3]selenazolo[3,2-c][1,2,3]triazoles from 1,2-bis(2-azidoaryl)diselenides and terminal alkynes under microwave irradiation.
Wystan K. O. Teixeira, Danilo Yano de Albuquerque, Julio Zukerman-Schpector, Diego Seckler, Daniel S. Rampon, Ricardo S. Schwab   +5 more
openaire   +2 more sources

Biocompatible photoinduced CuAAC using sodium pyruvate

Chemical Communications, 2021
The use of sodium pyruvate as a photoreducing agent for copper-mediated azide–alkyne cycloaddition (CuAAC) under UV irradiation is described.
Jaepil Jeong, Grzegorz Szczepaniak, Saigopalakrishna S. Yerneni, Francesca Lorandi, Hossein Jafari, Sushil Lathwal, Subha R. Das, Krzysztof Matyjaszewski   +7 more
openaire   +3 more sources

Insight into the Mechanism of the CuAAC Reaction by Capturing the Crucial Au4Cu4-π-Alkyne Intermediate.

Journal of the American Chemical Society, 2021
The classic Fokin mechanism of the CuAAC reaction of terminal alkynes using a variety of Cu(I) catalysts is well-known to include alkyne deprotonation involving a bimetallic σ,π-alkynyl intermediate.
Yaping Fang, K. Bao, Peng Zhang, Hongting Sheng, Yapei Yun, Shu-Xian Hu, D. Astruc, Manzhou Zhu   +7 more
semanticscholar   +1 more source

Simple method for ultrasound assisted «click» modification of azido-chitosan derivatives by CuAAC.

Carbohydrate Polymers, 2022
New quaternized chitosan derivatives HT-TMC were synthesized as a result of copper catalyzed azide-alkyne [3 + 2] cycloaddition (CuAAC). The structure of the HT-TMC was verified by 2D NMR.
A. Lunkov, B. Shagdarova, T. Lyalina, M. Dubinnyi, N. Karpova, S. Lopatin, A. Il’ina, V. Varlamov   +7 more
semanticscholar   +1 more source

CuX Dual Catalysis: Construction of Oxazolo[2,3-b][1,3]oxazines via a Tandem CuAAC/Ring Cleavage/[4+2+3] Annulation Reaction.

Organic Letters, 2022
CuX as a simple dual catalyst strategy that promotes the tandem transformations of fused oxazolo[2,3-b][1,3]oxazines has been developed. Copper catalyzed terminal ynones, sulfonyl azides, and nitriles for the CuAAC/ring cleavage/[4+2] annulation reaction,
Xiai Luo, Zhongtao Yang, Jia Zheng, G. Liang, Hui‐Yun Luo, Weiguang Yang   +5 more
semanticscholar   +1 more source

2.1 Introduction to CuAAC

2022
AbstractThe basic principles of the copper-catalyzed azide–alkyne cycloaddition reaction (CuAAC), widely considered to be the first click reaction, are described. This involves amongst others the concept of click reactions, the mechanism of CuAAC, the synthesis and reactivity of organic azides and acetylenes, an overview of most commonly used copper(I)
F. F. Ort, F. P. J. T. Rutjes
openaire   +1 more source

2.4 CuAAC in Carbohydrate Conjugation

2022
AbstractCopper(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC), as a versatile, reliable, and modular strategy, have been widely investigated in the area of glycoscience during the last 20 years. Herein, we presented a brief overview of CuAAC click approaches for easy access to diverse simple and complex triazole-appended carbohydrate ...
A. K. Agrahari, A. Mishra, V. K. Tiwari
openaire   +1 more source

2.3 CuAAC in Protein Conjugation

2022
AbstractThis chapter summarizes the use of the copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in the synthesis of peptide and protein conjugates. The different reaction conditions used for construction of the conjugates and their application in various disciplines are covered. Synthetic strategies for the introduction of the click groups (
A. La Venia, A. Kovalová, M. Vrabel
openaire   +1 more source