Results 181 to 190 of about 11,111 (220)
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Copper-Mediated Intramolecular Interrupted CuAAC Selanylation
The Journal of Organic Chemistry, 2023We, herein, describe a copper-mediated domino CuAAC intramolecular selanylation for the synthesis of unprecedented fused benzo[4,5][1,3]selenazolo[3,2-c][1,2,3]triazoles from 1,2-bis(2-azidoaryl)diselenides and terminal alkynes under microwave irradiation.
Wystan K. O. Teixeira +5 more
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Polymer “Clicking” by CuAAC Reactions
Macromolecular Rapid Communications, 2008AbstractThe CuAAC “click” reaction has developed as one of the most useful and widely employed reactions in ligation within polymer chemistry. This is due to the unique properties of the Cu(I) catalysis which renders the reaction quantitative even at low concentrations, orthogonal with other chemistries and extremely robust.
Morten Meldal
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A Fluxional Copper Acetylide Cluster in CuAAC Catalysis
Angewandte Chemie - International Edition, 2015AbstractA molecularly defined copper acetylide cluster with ancillary N‐heterocyclic carbene (NHC) ligands was prepared under acidic reaction conditions. This cluster is the first molecular copper acetylide complex that features high activity in copper‐catalyzed azide–alkyne cycloadditions (CuAAC) with added acetic acid even at −5 °C.
Bernd F Straub +2 more
exaly +3 more sources
2022
AbstractThe basic principles of the copper-catalyzed azide–alkyne cycloaddition reaction (CuAAC), widely considered to be the first click reaction, are described. This involves amongst others the concept of click reactions, the mechanism of CuAAC, the synthesis and reactivity of organic azides and acetylenes, an overview of most commonly used copper(I)
F. F. Ort, F. P. J. T. Rutjes
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AbstractThe basic principles of the copper-catalyzed azide–alkyne cycloaddition reaction (CuAAC), widely considered to be the first click reaction, are described. This involves amongst others the concept of click reactions, the mechanism of CuAAC, the synthesis and reactivity of organic azides and acetylenes, an overview of most commonly used copper(I)
F. F. Ort, F. P. J. T. Rutjes
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Recent Fascinating Aspects of the CuAAC Click Reaction
Trends in Chemistry, 2020CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts as a true click chemistry reaction allowing densely functional molecular fragments to be joined in a highly controlled manner. Using supercatalysts based on our mechanistic understanding and in the absence of oxygen, CuAAC reactions are superior even in bioligation
Frederik Diness, Morten Meldal
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Application of CuAAC for the covalent immobilization of homogeneous catalysts
Tetrahedron, 2014 : The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is arguably the flagship of the “click” chemistry concept introduced by Sharpless, a concept that revived some well-established reactions which respond the essential criteria of being ...
Alain Jonas +2 more
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2.4 CuAAC in Carbohydrate Conjugation
2022AbstractCopper(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC), as a versatile, reliable, and modular strategy, have been widely investigated in the area of glycoscience during the last 20 years. Herein, we presented a brief overview of CuAAC click approaches for easy access to diverse simple and complex triazole-appended carbohydrate ...
A. K. Agrahari, A. Mishra, V. K. Tiwari
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4-Azidotetrahydroquinazoline derivatives in CuAAC reaction
Mendeleev Communications, 20204-Azido-2-methyltetrahydroquinazoline N-oxide cleanly undergoes the copper( i )-catalyzed azide–alkyne cycloaddition (CuAAC) reaction with alkynes to give new conjugates with pyrimidine N-oxide and triazole moieties. Its deoxygenated analogue, 4-azido-2-methyltetrahydroquinazoline, is inert in CuACC process due to the shift of imidoyl azide–tetrazole ...
Yuri Grishin +2 more
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2.2 CuAAC in Peptidomimetics and Protein Mimics
2022AbstractThe tremendous recent developments in click chemistry, including the impressive developments of strain-promoted cycloaddition reagents, all started with the copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction conceived by Meldal et al. and Sharpless et al.
T. J. Meuleman, R. M. J. Liskamp
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The application of CuAAC ‘click’ chemistry to catenane and rotaxane synthesis
Chem. Soc. Rev., 2010The copper(I)-catalysed azide-alkyne cycloaddition (the CuAAC 'click' reaction) is proving to be a powerful new tool for the construction of mechanically interlocked molecular-level architectures. The reaction is highly selective for the functional groups involved (terminal alkynes and azides) and the experimental conditions are mild and compatible ...
Leigh, D A; id_orcid 0000-0002-1202-4507 +1 more
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