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Recent Fascinating Aspects of the CuAAC Click Reaction
Trends in Chemistry, 2020CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts as a true click chemistry reaction allowing densely functional molecular fragments to be joined in a highly controlled manner. Using supercatalysts based on our mechanistic understanding and in the absence of oxygen, CuAAC reactions are superior even in bioligation
Morten Meldal, Frederik Diness
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2.3 CuAAC in Protein Conjugation
2022AbstractThis chapter summarizes the use of the copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in the synthesis of peptide and protein conjugates. The different reaction conditions used for construction of the conjugates and their application in various disciplines are covered. Synthetic strategies for the introduction of the click groups (
A. La Venia, A. Kovalová, M. Vrabel
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4-Azidotetrahydroquinazoline derivatives in CuAAC reaction
Mendeleev Communications, 20204-Azido-2-methyltetrahydroquinazoline N-oxide cleanly undergoes the copper( i )-catalyzed azide–alkyne cycloaddition (CuAAC) reaction with alkynes to give new conjugates with pyrimidine N-oxide and triazole moieties. Its deoxygenated analogue, 4-azido-2-methyltetrahydroquinazoline, is inert in CuACC process due to the shift of imidoyl azide–tetrazole ...
Anna A. Nazarova +5 more
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Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update
Organic & Biomolecular Chemistry, 2015The recent advances in the copper-catalysed azide–alkyne cycloaddition (CuAAC) reactions are reviewed.
Estela, Haldón +2 more
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2.2 CuAAC in Peptidomimetics and Protein Mimics
2022AbstractThe tremendous recent developments in click chemistry, including the impressive developments of strain-promoted cycloaddition reagents, all started with the copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction conceived by Meldal et al. and Sharpless et al.
T. J. Meuleman, R. M. J. Liskamp
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When CuAAC 'Click Chemistry' goes heterogeneous
Catalysis Science & Technology, 2016Within the green chemistry context, heterogeneous catalysis is more and more applied to organic synthesis. The well known ‘click chemistry’ and especially its flagship, the copper-catalyzed azide–alkyne cycloaddition reaction (CuAAC), is now catch up by such heterogenisation process and copper ions or metals have been grafted or deposited on or into ...
S. Chassaing, V. Bénéteau, P. Pale
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Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC)
2022Contains fulltext : 310029.pdf (Publisher’s version ) (Closed access)
Rutjes, F.P.J.T., Ort, F.F.
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Arylazopyrazoles for Conjugation by CuAAC Click Chemistry
The Journal of Organic ChemistryMolecular photoswitches are increasingly being implemented in bioactive compounds and responsive materials. For this purpose, photoswitches must be coupled to a wide variety of substrates and scaffolds. We present a library of "clickable" arylazopyrazoles (AAPs), which can be conjugated by Cu-catalyzed alkyne azide cycloaddition (CuAAC).
Alisa-Maite Kauth +2 more
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CuAAC-Based Click Chemistry in Self-Healing Polymers
Accounts of Chemical Research, 2017Click chemistry has emerged as a significant tool for materials science, organic chemistry, and bioscience. Based on the initial concept of Barry Sharpless in 2001, the copper(I)-catalyzed azide/alkyne cycloaddition (CuAAC) reaction has triggered a plethora of chemical concepts for linking molecules and building blocks under ambient conditions, forming
Diana Döhler +2 more
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CuAAC: An Efficient Click Chemistry Reaction on Solid Phase
ACS Combinatorial Science, 2015Click chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), to bind two molecular building blocks. CuAAC has broad applications in medicinal chemistry and other fields of chemistry.
Vida, Castro +2 more
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