Results 201 to 210 of about 15,690 (247)

Lipopolysaccharide confinement in the bacterial outer membrane is governed by interactions within the conserved Lipid A anchor. [PDF]

EMBO J
Nabarro J, Leaman RM, Lenton S, Mantion L, Spears RJ, Coles MC, Pushkin DO, Fascione MA, Baumann CG.   +8 more
europepmc   +1 more source

Harnessing oligonucleotide architecture for potent multivalent inhibition of human carbonic anhydrases. [PDF]

RSC Med Chem
Abbass EM, Ladu F, Mansot J, Noël M, Nocentini A, Sechi M, Supuran CT, Smietana M, Winum JY.   +8 more
europepmc   +1 more source

Exploring the versatility of heterocyclic compounds containing nitrogen atoms (triazoles): a comprehensive review. [PDF]

RSC Adv
Akram M, Tamminana R.
europepmc   +1 more source

Enhancing the CuAAC efficiency of a Cu(I)-NHC complex in biological media by encapsulation.

Chem Commun (Camb)
Prakasham AP, Singh H, Palmans ARA.
europepmc   +1 more source

Supramolecular assembly properties of a mixed-sequence recognition-encoded melamine oligomer.

Org Biomol Chem
Dhiman M, Smith JT, Hunter CA.
europepmc   +1 more source

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Polymer “Clicking” by CuAAC Reactions

Macromolecular Rapid Communications, 2008
AbstractThe CuAAC “click” reaction has developed as one of the most useful and widely employed reactions in ligation within polymer chemistry. This is due to the unique properties of the Cu(I) catalysis which renders the reaction quantitative even at low concentrations, orthogonal with other chemistries and extremely robust.
Morten Meldal
exaly   +2 more sources

A Fluxional Copper Acetylide Cluster in CuAAC Catalysis

Angewandte Chemie - International Edition, 2015
AbstractA molecularly defined copper acetylide cluster with ancillary N‐heterocyclic carbene (NHC) ligands was prepared under acidic reaction conditions. This cluster is the first molecular copper acetylide complex that features high activity in copper‐catalyzed azide–alkyne cycloadditions (CuAAC) with added acetic acid even at −5 °C.
Ata Makarem, Frank Rominger, Bernd F Straub   +2 more
exaly   +3 more sources

Recent Fascinating Aspects of the CuAAC Click Reaction

Trends in Chemistry, 2020
CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts as a true click chemistry reaction allowing densely functional molecular fragments to be joined in a highly controlled manner. Using supercatalysts based on our mechanistic understanding and in the absence of oxygen, CuAAC reactions are superior even in bioligation
Morten Meldal, Frederik Diness
exaly   +3 more sources

4-Azidotetrahydroquinazoline derivatives in CuAAC reaction

Mendeleev Communications, 2020
4-Azido-2-methyltetrahydroquinazoline N-oxide cleanly undergoes the copper( i )-catalyzed azide–alkyne cycloaddition (CuAAC) reaction with alkynes to give new conjugates with pyrimidine N-oxide and triazole moieties. Its deoxygenated analogue, 4-azido-2-methyltetrahydroquinazoline, is inert in CuACC process due to the shift of imidoyl azide–tetrazole ...
Kseniya N Sedenkova, Dmitry A Vasilenko, Yuri K Grishin   +2 more
exaly   +2 more sources

‘Click’ glycosylation of peptides through cysteine propargylation and CuAAC

Bioorganic and Medicinal Chemistry, 2014
'Click' glycosylation of cysteine-containing peptides were carried out in good yield by Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC). For that peptides were functionalized though direct propargylation of the cysteine residue allowing their use in CuAAC with suitable free or protected azido sugars of gluco, manno and galacto configuration ...
Sandrine Lamandé-Langle, Charlotte Collet, Raphaël Hensienne   +2 more
exaly   +3 more sources