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Recent Fascinating Aspects of the CuAAC Click Reaction

Trends in Chemistry, 2020
CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts as a true click chemistry reaction allowing densely functional molecular fragments to be joined in a highly controlled manner. Using supercatalysts based on our mechanistic understanding and in the absence of oxygen, CuAAC reactions are superior even in bioligation
Meldal, Morten, Diness, Frederik
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Photopolymerization Reactions Using the Photoinitiated Copper (I)‐Catalyzed Azide‐Alkyne Cycloaddition (CuAAC) Reaction

Advanced Materials, 2013
The first bulk photopolymerization of multifunctional alkyne and azide monomers using the CuAAC reaction is successfully carried out from low molecular weight, nonviscous monomer resins. Compared to other traditional step-growth bulk photopolymerization, this approach readily provides crosslinked, high glass transition temperature polymers that ...
Tao, Gong   +3 more
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Polymer “Clicking” by CuAAC Reactions

Macromolecular Rapid Communications, 2008
AbstractThe CuAAC “click” reaction has developed as one of the most useful and widely employed reactions in ligation within polymer chemistry. This is due to the unique properties of the Cu(I) catalysis which renders the reaction quantitative even at low concentrations, orthogonal with other chemistries and extremely robust.
Morten Meldal
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4-Azidotetrahydroquinazoline derivatives in CuAAC reaction

Mendeleev Communications, 2020
4-Azido-2-methyltetrahydroquinazoline N-oxide cleanly undergoes the copper( i )-catalyzed azide–alkyne cycloaddition (CuAAC) reaction with alkynes to give new conjugates with pyrimidine N-oxide and triazole moieties. Its deoxygenated analogue, 4-azido-2-methyltetrahydroquinazoline, is inert in CuACC process due to the shift of imidoyl azide–tetrazole ...
Anna A. Nazarova   +5 more
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Construction of sequence-defined polytriazoles by IrAAC and CuAAC reactions

Chemical Communications, 2020
A novel sequence-defined polytriazole architecture was synthesized by IrAAC and CuAAC.
Changhong Ju   +4 more
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CuAAC: An Efficient Click Chemistry Reaction on Solid Phase

ACS Combinatorial Science, 2015
Click chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), to bind two molecular building blocks. CuAAC has broad applications in medicinal chemistry and other fields of chemistry.
Vida, Castro   +2 more
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Various polystyrene topologies built from tailored cyclic polystyrene via CuAAC reactions

Chemical Communications, 2010
Rapid CuAAC cross-coupling reactions catalyzed by CuBr/PMDETA in toluene afforded complex architectures from functional polymeric cyclic blocks. Various topologies (from paddle-like to 3-arm stars) rapidly formed with high conversion at 25 °C. Remarkably, this approach overcame significant steric hindrance linking polymeric cyclic structures with high ...
Lonsdale, DE, Monteiro, MJ
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Mechanochemical Activation of Fluorogenic CuAAC “Click” Reactions for Stress‐Sensing Applications

Macromolecular Rapid Communications, 2018
AbstractStrategies for visualizing stress within polymeric materials are of growing interest during the past decade. In this paper, stress‐sensing materials, triggered by a mechanoresponsive catalytic system based on latent copper(I)bis(N‐heterocyclic carbene) mechanophores, are reported, which can be activated by compression force to trigger a ...
Philipp Michael   +2 more
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