Results 31 to 40 of about 12,742 (207)

Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment [PDF]

, 2014
The rapidly increasing interest in the synthesis of antibody–drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of the power of antibodies and antibody fragments as highly selective targeting moieties.
Boyle, Ross W., Bryden, Francesca, Caddick, Stephen, Chudasama, Vijay, Maruani, Antoine, Savoie, Huguette, Smith, Mark E. B.   +6 more
core   +1 more source

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase [PDF]

, 2016
We thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support.
Fleming, Ian N., O’Hagan, David, Thompson, Stephen   +2 more
core   +1 more source

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S, Chester, KA, Chudasama, V, Maruani, A, Miranda, E, Smith, ME   +5 more
core   +1 more source

Intermediates Stabilized by Tris(triazolylmethyl)amines in the CuAAC Reaction

Chemistry – A European Journal, 2017
AbstractTris(triazolylmethyl)amine ligands (TL) are widely used to accelerate the CuI‐catalyzed azide‐alkyne cycloaddition (CuAAC) reaction, but its mechanistic role remains unclear. Using electrospray ionization mass spectrometry, we detected for the first time the trinuclear TL‐CuI3‐acetylide and the dinuclear TL‐CuI2‐acetylide complexes in aqueous ...
Haoqing Chen, Chengzhi Cai, Siheng Li, Yong Ma, Sijin Luozhong, Zhiling Zhu   +5 more
openaire   +3 more sources

Strategy for Conditional Orthogonal Sequential CuAAC Reactions Using a Protected Aromatic Ynamine [PDF]

The Journal of Organic Chemistry, 2017
A method for conditional control of orthogonal sequential Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC reaction of less reactive alkynes.
Marine Z. C. Hatit, Ciaran P. Seath, Allan J. B. Watson, Glenn A. Burley   +3 more
openaire   +3 more sources

A Photoswitchable Chalcone-Carbohydrate Conjugate Obtained by CuAAC Click Reaction

Compounds, 2022
Flavylium/Chalcone-based molecular switches comprise features such as pH-gated photochromism and fluorescence properties that make them attractive for many applications, ranging from stimuli-responsive materials to photopharmacology. However, in contrast to other common photoswitches, the application of flavylium compounds in these areas remains ...
Micael Paulino, Maria Manuela A. Pereira, Nuno Basílio   +2 more
openaire   +2 more sources

Mechanism of CuAAC reaction: In acetic acid and aprotic conditions

Journal of Molecular Catalysis A: Chemical, 2017
Abstract Protonation of copper-triazolide is a distinctive and final part in CuAAC reaction which has kinetic importance such that it can even affect the product distribution. In the context of this study, the protonation mechanism of copper-triazolide was investigated with quantum mechanical calculations to have a deeper understanding of the ...
Ozen, Cihan, Tuzun, Nurcan Senyurt
openaire   +2 more sources

Fluorogenic “click” reaction for labeling and detection of DNA in proliferating cells

BioTechniques, 2010
A thymidine analog, 5-ethynyl-2′-deoxyuridine (EdU), has been reported as a rapid labeling tool for direct measurement of cells in S-phase. The alkynyl group of EdU is a biologically inert group that undergoes an extremely selective reaction with azido ...
Kai Li, L. Andrew Lee, Xiaobing Lu, Qian Wang   +3 more
doaj   +1 more source

Responsive glyco-poly(2-oxazoline)s: synthesis, cloud point tuning, and lectin binding [PDF]

, 2011
A new sugar-substituted 2-oxazoline monomer was prepared using the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. Its copolymerization with 2-ethyl-2-oxazoline as well as 2-(dec-9-enyl)-2-oxazoline, yielding well-defined copolymers with ...
Adams N., Ambrosi M., Aoi K., Aoi K., Aoi K., Aoi K., Bassiri T. G., Bloksma M. M., Campos L. M., Cesana S., Christine Weber, Christova D., Collins B. E., Cortez M. A., Diehl C., Dimick S. M., Gabius H. J., Hoogenboom R., Hoogenboom R., Huber S., Kagiya T., Kempe K., Kempe K., Knop K., Kobayashi S., Kobayashi S., Kobayashi S., Kristian Kempe, Krzysztof Babiuch, Lambermont-Thijs H. M. L., Lin P. Y., Lundquist J. J., Michael Gottschaldt, Mikata Y., Narain R., Richard Hoogenboom, Saegusa T., Saegusa T., Seeliger W., Slavin S., Stillman B. N., Takasu A., Taubmann C., Ting S. R. S., Tomalia D. A., Tsutsumiuchi K., Ulrich S. Schubert, Vazquez-Dorbatt V., Weber C., Wiesbrock F., Wiesbrock F., Witte H.   +51 more
core   +2 more sources

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes

Beilstein Journal of Organic Chemistry, 2018
A copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported.
Muhammad Israr, Changqing Ye, Munira Taj Muhammad, Yajun Li, Hongli Bao   +4 more
doaj   +1 more source