Integrated metabolomic and transcriptomic analyses elucidates the molecular mechanisms underlying cucurbitacin accumulation and bitterness development in Luffa fruits [PDF]
BMC Plant BiologyThe fruits of Luffa in the Cucurbitaceae family are characterized by a bitter taste, which is mainly attributed to cucurbitacin. However, the types of cucurbitacins related to bitterness and the molecular mechanism of cucurbitacin accumulation during ...
Dening Zhu +4 more
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International Journal of Molecular Sciences, 2022 Pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), induce the expression of intracellular adhesion molecule-1 (ICAM-1) by activating the nuclear factor κB (NF-κB) signaling pathway.
Takao Kataoka
exaly +2 more sources
Profiling and cheminformatics bioprospection of curcurbitacin I and momordin Ic from Momordica balsamina on α-amylase and α-glucosidase [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryMomordica spp. has been traditionally used to manage type 2 diabetes mellitus, but the mechanisms and metabolites remain unclear. This study evaluated the inhibitory potential of Momordica balsamina extracts on α-amylase and α-glucosidase in vitro ...
Viruska Jaichand +4 more
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Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background In silico studies further provided predictive binding properties of selected ligands for inhibition of target protein. In the study, molecular binding poses of Cucurbitacin-E and antioxidant enzymes (glutathione-S-transferase (GST), superoxide
Fahriye Sümer Ercan +2 more
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Cucurbitacin IIa Ameliorates DSS-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Inhibiting PERK/ATF4/CHOP Signaling Pathway [PDF]
The Turkish Journal of GastroenterologyBackground/Aims: The primary intent of this manuscript is to ascertain the effect of cucurbitacin IIa on ulcerative colitis (UC) and illustrate the potential mechanisms based on intestinal barrier function and the PERK/ATF4/CHOP signaling pathway ...
Yang Yang, Qiong Yang
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Cucurbitacin IIa Alleviates Colitis via Promoting the Release of Host-Derived Extracellular Vesicles Encapsulating microRNA-30b-5p [PDF]
Journal of Inflammation ResearchYinyin Zhao,1 Binyuan Jiang,2 Shengnan Zuo3 1Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Medical Research Center of the ...
Zhao Y, Jiang B, Zuo S
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RETRACTION: <i>Trichosanthes kirilowii</i> Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells. [PDF]
Evid Based Complement Alternat MedEvidence-Based Complementary and Alternative Medicine, Volume 2026, Issue 1, 2026.
And Alternative Medicine EC.
europepmc +2 more sources
Lebensmittelvergiftung durch Cucurbitacine
DMW - Deutsche Medizinische Wochenschrift, 2020 Zusammenfassung Anamnese und klinischer Befund Die 66-jährige Patientin ist wegen einer akuten Lebensmittelvergiftung nach Ingestion von bitteren Zucchini in die Notaufnahme mit Tachykardie, Hypotonie und Somnolenz sowie Exsikkose, Übelkeit, Erbrechen und Hämatochezie eingewiesen worden.
Jung, Carlo +2 more
openaire +3 more sources
Pharmacological Research, 2021 Pyroptosis, a type of programmed cell death (PCD), is characterized by cell swelling with bubbles, and the release of inflammatory cell cytokines.
Renyikun Yuan +7 more
semanticscholar +1 more source
The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells. [PDF]
PLoS ONE, 2013 Cucurbitacin B (CuB) is one of the potential agents for long term anticancer chemoprevention. Cumulative evidences has shown that cucurbitacin B provides potent cellular biological activities such as hepatoprotective, anti-inflammatory and antimicrobial ...
Moltira Promkan +4 more
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