Results 21 to 30 of about 15,621 (174)
Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells
Biochemistry and Biophysics Reports, 2020 Cutaneous T-cell lymphomas and leukemias (CTCLs) are a heterogeneous group of extranodal non-Hodgkin's lymphomas. These are characterized by an accumulation of malignant CD4+ T-lymphocytes in the skin, lymph nodes, and peripheral blood.
Isabella J. Brouwer +3 more
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Toxins, 2022 We examined a two-step target protein binding strategy that uses cofilin as the target protein to analyze the active constituents in Bryonia cretica. In the first step, we prepared the target protein, and used it to analyze the compounds binding to it in
Souichi Nakashima +6 more
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BMC Complementary and Alternative Medicine, 2012 Background Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from the Thai medicinal plant Trichosanthes cucumerina L., has been reported to have several biological activities including anti-inflammatory, antimicrobial and ...
Duangmano Suwit +4 more
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PLoS ONE, 2015 Cucurbitacin I is a naturally occurring triterpenoid derived from Cucurbitaceae family plants that exhibits a number of potentially useful pharmacological and biological activities.
Moon Hee Jeong +6 more
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Integrative Cancer Therapies, 2022 Owing to the crucial role of Src in cancer metastasis, interruption of Src and its signaling has been considered a promising strategy for cancer metastasis treatment.
Putthaporn Kaewmeesri MS +5 more
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Cucurbitacin E Targets Proliferating Endothelia
Journal of Surgical Research, 1997 Tumor vasculature offers a target for drugs directed against proliferating endothelia. We hypothesized that cucurbitacin E (CuE), an actin-disrupting agent, would preferentially inhibit proliferating vs. quiescent endothelia. Log-phase and confluent ECV304 and HUVEC human endothelial cells were exposed to 10-200 nM CuE for 1-96 hr, and toxicity was ...
M D, Duncan, K L, Duncan
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Molecules, 2023 A new series of nitric oxide-releasing estra-1,3,5,16-tetraene analogs (NO-∆-16-CIEAs) was designed and synthesized as dual inhibitors for EGFR and MRP2 based on our previous findings on estra-1,3,5-triene analog NO-CIEA 17 against both HepG2 and HepG2-R
Mahrous A. Abou-Salim +5 more
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Effect of Cucurbitacin I on Proliferation and Migration in Colorectal Cancer Cell Line, LS174T
Proceedings, 2017 Cucurbitacin I is a natural component extracted from plants of the Cucurbitaceae family and has shown anti-cancer activity against various types of cancer. The aim of the present study was to investigate its antiproliferative and antimigratory effects on
Emir Tosun, Ahmet Baysar
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Induction of AHR Gene Expression in Colorectal Cancer Cell Lines by Cucurbitacin D, E, and I [PDF]
Journal of Cell and Molecular Research, 2019 Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and its induction may result in suppressing of cell proliferation in colorectal cancer (CRC).
Younes Aftabi +4 more
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Pharmacokinetics and Biological Activity of Cucurbitacins
Pharmaceuticals, 2022 Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and anticancer biological actions. This review addresses pharmacokinetic parameters recently reported, including absorption, metabolism, distribution, and elimination ...
Eugenia Elisa Delgado-Tiburcio +6 more
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