Results 11 to 20 of about 15,621 (174)

Lebensmittelvergiftung durch Cucurbitacine

DMW - Deutsche Medizinische Wochenschrift, 2020
Zusammenfassung Anamnese und klinischer Befund Die 66-jährige Patientin ist wegen einer akuten Lebensmittelvergiftung nach Ingestion von bitteren Zucchini in die Notaufnahme mit Tachykardie, Hypotonie und Somnolenz sowie Exsikkose, Übelkeit, Erbrechen und Hämatochezie eingewiesen worden.
Jung, Carlo, Steuber, Benjamin, Schwörer, Harald   +2 more
openaire   +3 more sources

The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells. [PDF]

PLoS ONE, 2013
Cucurbitacin B (CuB) is one of the potential agents for long term anticancer chemoprevention. Cumulative evidences has shown that cucurbitacin B provides potent cellular biological activities such as hepatoprotective, anti-inflammatory and antimicrobial ...
Moltira Promkan, Sumana Dakeng, Subhas Chakrabarty, Oliver Bögler, Pimpicha Patmasiriwat   +4 more
doaj   +1 more source

Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes

Journal of Translational Medicine, 2023
Background Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological change in osteoarthritis, and persistent inflammation is one of the driving factors of cartilage degeneration.
Lin Wang, Hui Xu, Xin Li, Hongwei Chen, Haigang Zhang, Xunpeng Zhu, Zhijie Lin, Shilei Guo, Zhibo Bao, Haicheng Rui, Wei He, Hui Zhang   +11 more
doaj   +1 more source

Cucurbitacins: elucidation of their interactions with the cytoskeleton [PDF]

PeerJ, 2017
Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments.
Xiaojuan Wang, Mine Tanaka, Herbenya Silva Peixoto, Michael Wink   +3 more
doaj   +2 more sources

Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats

BMC Complementary and Alternative Medicine, 2019
Background Cucurbitacin B is the major bioactive constituent in Trichosanthes cucumerina L. fruits, which the pharmacological properties have been studied for decades particularly an anti-tumor activity.
Natthaphon Hunsakunachai, Nitra Nuengchamnong, Weena Jiratchariyakul, Tanawan Kummalue, Phisit Khemawoot   +4 more
doaj   +1 more source

Chloroform Fraction of Cucumis melo L. ‘Gama Melon Parfum’ Cytotoxicity against Breast Cancer Cell T47D and MCF7 [PDF]

BIO Web of Conferences, 2022
Nature is the source of various types of phytochemicals. Some of them are unique chemical compounds only found in certain plants. For example, Cucurbitacin is found in the family Cucurbitaceae.
Salamah Rohmi, Widiyanto Slamet
doaj   +1 more source

Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. [PDF]

PLoS ONE, 2010
Cucurbitacins are plant natural products that inhibit activation of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway by an unknown mechanism.
David A Knecht, Rebecca A LaFleur, Alem W Kahsai, Christian E Argueta, Anwar B Beshir, Gabriel Fenteany, Gabriel Fenteany   +6 more
doaj   +1 more source

Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling

International Journal of Immunopathology and Pharmacology, 2018
Cucurbitacins are triterpenoids commonly found in Cucurbitaceae and Cruciferae and have long been used in traditional medicine. Cucurbitacins demonstrate anti-inflammatory and anti-cancer activities.
Jin Mo Ku, Se Hyang Hong, Hyo In Kim, Ye Seul Lim, Sol Ji Lee, Mia Kim, Hye Sook Seo, Yong Cheol Shin, Seong-Gyu Ko   +8 more
doaj   +1 more source

Enhanced antitumor activity of cucurbitacin B combined with cerulenin in osteosarcoma

Bangladesh Journal of Pharmacology, 2015
In the present study, the effect of cucurbitacin B and cerulenin combination on osteosarcoma was investigated to develop an effective treatment regimen.
Zhe Zhang, Ying Shen, Jian Wu, Lin Cai
doaj   +1 more source

The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain

Frontiers in Pharmacology, 2023
Paclitaxel (sold under the brand name Taxol) is a chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Keun-Tae Park, Suyong Kim, Ilseob Choi, Ik-Hwan Han, Hyunsu Bae, Woojin Kim, Woojin Kim   +6 more
doaj   +1 more source