Results 21 to 30 of about 20,694 (254)
VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation [PDF]
, 2014 Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis.
He, Xian-Hui +9 more
core +6 more sources
Cucurbitacin B: A Review of its Pharmacology, Toxicity, and Pharmacokinetics.
Pharmacological Research, 2022 Cucurbitacin B (CuB, C32H46O8), the most abundant and active member of cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely distributed in a variety of plants and mainly isolated from plants in the Cucurbitaceae ...
Shuang-Hua Dai +7 more
semanticscholar +1 more source
Cucurbitacins: elucidation of their interactions with the cytoskeleton [PDF]
PeerJ, 2017 Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments.
Xiaojuan Wang +3 more
doaj +2 more sources
Potential of cucurbitacin as an anticancer drug.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 In Chinese medicine, the Cucurbitaceae family contains many compounds known as cucurbitacins, which have been categorized into 12 classes ranging from A to T and more than 200 derivatives.
Yan Li +6 more
semanticscholar +1 more source
Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons [PDF]
, 2014 Natural molecules are under intensive study for their potential as preventive and/or adjuvant therapies for neurodegenerative disorders such as Parkinson’s disease (PD).
Arel-Dubeau, Anne-Marie +8 more
core +8 more sources
Pest Management Science, 2023 Botrytis cinerea is the primary disease affecting cucumber production. It can be managed by applying pesticides and cultivating disease-resistant cucumber strains.
Y. Jia +10 more
semanticscholar +1 more source
Chinese Medicine, 2022 Background Lung cancer is the leading cause of cancer mortality worldwide, and most of the patients after treatment with EGF-TKIs develop drug resistance, which is closely correlated with EMT. Cucurbitacin B (CuB) is a natural product of the Chinese herb
Renyikun Yuan +8 more
semanticscholar +1 more source
Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats
BMC Complementary and Alternative Medicine, 2019 Background Cucurbitacin B is the major bioactive constituent in Trichosanthes cucumerina L. fruits, which the pharmacological properties have been studied for decades particularly an anti-tumor activity.
Natthaphon Hunsakunachai +4 more
doaj +1 more source
Chloroform Fraction of Cucumis melo L. ‘Gama Melon Parfum’ Cytotoxicity against Breast Cancer Cell T47D and MCF7 [PDF]
BIO Web of Conferences, 2022 Nature is the source of various types of phytochemicals. Some of them are unique chemical compounds only found in certain plants. For example, Cucurbitacin is found in the family Cucurbitaceae.
Salamah Rohmi, Widiyanto Slamet
doaj +1 more source
Current Issues in Molecular Biology, 2023 EGFR tyrosine kinase inhibitors (TKIs) are the first-line treatment for advanced EGFR-mutated non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mutation are ineligible for EGFR-TKIs.
Han-Lin Hsu +7 more
semanticscholar +1 more source