Results 41 to 50 of about 20,694 (254)
Inhibitory Activity of Leaves Extracts of Citrullus colocynthis Schrad. on HT29 Human Colon Cancer Cells [PDF]
, 2016 Aims: Citrullus colocynthis is a plant endemic in Asia, Africa and in the Mediterranean basin. It is used in folk medicine against infections, inflammations and cardiovascular and immune-related diseases.
Aouni, M +8 more
core +1 more source
Acta Pharmaceutica Sinica B, 2022 Conjunctival melanoma (CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B (CuB).
Jinlian Wei +13 more
semanticscholar +1 more source
PLoS ONE, 2015 Cucurbitacin I is a naturally occurring triterpenoid derived from Cucurbitaceae family plants that exhibits a number of potentially useful pharmacological and biological activities.
Moon Hee Jeong +6 more
doaj +1 more source
Cucurbitacin E Targets Proliferating Endothelia
Journal of Surgical Research, 1997 Tumor vasculature offers a target for drugs directed against proliferating endothelia. We hypothesized that cucurbitacin E (CuE), an actin-disrupting agent, would preferentially inhibit proliferating vs. quiescent endothelia. Log-phase and confluent ECV304 and HUVEC human endothelial cells were exposed to 10-200 nM CuE for 1-96 hr, and toxicity was ...
M D, Duncan, K L, Duncan
openaire +2 more sources
Molecules, 2023 A new series of nitric oxide-releasing estra-1,3,5,16-tetraene analogs (NO-∆-16-CIEAs) was designed and synthesized as dual inhibitors for EGFR and MRP2 based on our previous findings on estra-1,3,5-triene analog NO-CIEA 17 against both HepG2 and HepG2-R
Mahrous A. Abou-Salim +5 more
doaj +1 more source
Effect of Cucurbitacin I on Proliferation and Migration in Colorectal Cancer Cell Line, LS174T
Proceedings, 2017 Cucurbitacin I is a natural component extracted from plants of the Cucurbitaceae family and has shown anti-cancer activity against various types of cancer. The aim of the present study was to investigate its antiproliferative and antimigratory effects on
Emir Tosun, Ahmet Baysar
doaj +1 more source
Induction of AHR Gene Expression in Colorectal Cancer Cell Lines by Cucurbitacin D, E, and I [PDF]
Journal of Cell and Molecular Research, 2019 Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and its induction may result in suppressing of cell proliferation in colorectal cancer (CRC).
Younes Aftabi +4 more
doaj +1 more source
Cucurbitacin I Reverses Tumor-Associated Macrophage Polarization to Affect Cancer Cell Metastasis
International Journal of Molecular Sciences, 2023 The tumor microenvironment plays a critical role in tumor progression and immune regulation. As one of the most important components of the tumor microenvironment, macrophages have become a new therapeutic target for inhibiting tumor progression. Despite
Xiaocheng Gong +7 more
semanticscholar +1 more source
Cellular and Molecular Biology, 2023 Cucurbitacin B, a tetracyclic triterpenoid compound extracted from various plants, has been proven to exert a vital role in various diseases. However, the effect of cucurbitacin B on myocardial infarction (MI) and ischemia-reperfusion (I/R) injury is ...
Chao Chen +7 more
semanticscholar +1 more source
Primary Human Macrophages Serve as Vehicles for Vaccinia Virus Replication and Dissemination [PDF]
, 2014 Human monocytic and professional antigen-presenting cells have been reported only to exhibit abortive infections with vaccinia virus (VACV). We found that monocyte-derived macrophages (MDMs), including granulocyte macrophage colony-stimulating factor (GM-
Amet, Tohti +7 more
core +1 more source