Results 81 to 90 of about 13,244,565 (235)

Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
The molecular mechanism for mulberrin regulating lipid metabolism homeostasis. ABSTRACT Lipid metabolism disorders and the induced metabolic diseases have risen to become one of the primary public health issues. Our preliminary experimental results confirmed that mulberry leaf flavonoid extract exhibited efficacy in lipid metabolism regulation; the ...
Qian Li, Daorui Pang, Erna Li, Dongxu Xing, Fan Liu, Li Wang, Yuxiao Zou   +6 more
wiley   +1 more source

Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells

Bangladesh Journal of Pharmacology, 2015
In the present study, the effect of cucurbitacin B (a natural product with anti-cancer effect) was studied on PC12 cells. It significantly reduced the cell number, changed cell morphology and inhibited colony formation while MTT results showed increased ...
Chuanhong Wu, Jiaolin Bao, Chengwei He, Jinjian Lu, Xiuping Chen   +4 more
doaj  

Study on seasonal variation on the content of Cucurbitacin of various vegetative parts of Trichosanthes cucumerina L. var. cucumerina [PDF]

, 2011
The total cucurbitacin content produced in the different parts of T. cucumerina L. var. cucumerina viz., fruit, stem and leaves with time and temperature was studied during the year 2007-08.
Attard, Everaldo, Devendra, N. K., Raghunandan, Deshpande, Seetharam, Y. N.   +3 more
core  

Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade [PDF]

, 2016
OBJECTIVE: Acquired chemoresistance is a major obstacle in the clinical management of ovarian cancer. Therefore, searching for alternative therapeutic modalities is urgently needed.
Al Rawahi T, D. Grahame Hardie, David W. Chan, Ferla R, Fiona A. Ross, Hextan Y. S. Ngan, Jinbiao Zhan, Kikkawa F, Limtrakul P, Mingo M. H. Yung, Pinto AL, Teh MT, Thomas H. Y. Leung   +12 more
core   +3 more sources

High‐throughput transcriptome mining and in silico screening reveal saccharide feeding stimulants for Cydia pomonella larvae

New Plant Protection, Volume 3, Issue 1, March 2026.
We identified and characterized the gustatory and ionotropic receptors of Cydia pomonella using transcriptomics and in silico approaches, linking candidate sugar receptors to larval feeding attraction. Functional assays and behavioral tests highlighted isoquercitrin as a key feeding stimulant, providing a foundation for olfactory‐ and taste‐based pest ...
Chenyun Ding, Zaiyuan Li, Qiang Wu, Bo Liu, Fanghao Wan, Cong Huang, Rui Tang   +6 more
wiley   +1 more source

Analysis of Active Compounds Using Target Protein Cofilin―Cucurbitacins in Cytotoxic Plant Bryonia cretica

Toxins, 2022
We examined a two-step target protein binding strategy that uses cofilin as the target protein to analyze the active constituents in Bryonia cretica. In the first step, we prepared the target protein, and used it to analyze the compounds binding to it in
Souichi Nakashima, Yoshimi Oda, Moeko Morita, Ayako Ohta, Toshio Morikawa, Hisashi Matsuda, Seikou Nakamura   +6 more
doaj   +1 more source

Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest [PDF]

, 2012
Purpose. To explore the effects of cucurbitacin B on the radiation survival of human breast cancer cells and to elucidate the cellular mechanism of radiosensitization if any. Materials and Methods.
Domann, Frederick E., Duangmano, Suwit, Patmasiriwat, Pimpicha, Sae-lim, Phorntip, Suksamrarn, Apichart   +4 more
core   +3 more sources

Cucurbitacin B induces ferroptosis in oral leukoplakia via the SLC7A11/mitochondrial oxidative stress pathway.

Phytomedicine
BACKGROUND Oral leukoplakia (OLK), characterized by abnormal epithelial hyperplasia, is the most common precancerous oral mucosa lesion and is closely related to oxidative stress.
Mengyuan Yang, Xin Chen, Chen Cheng, Wenpeng Yan, Rongrong Guo, Yajun Wang, Heng Zhang, Jiawei Chai, Yahsin Cheng, Fang Zhang   +9 more
semanticscholar   +1 more source

Mechanistic Insights for Microbiome Application in Plant Disease Resistance

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
This review summarises the mechanisms underlying plant‐guided microbiome modulation and probiotic‐mediated disease suppression. Additionally, it highlights the challenges to be addressed for a better microbiome application of disease resistance in sustainable agriculture and proposes possible strategies. Figure was created with BioRender.
Jiakang Yin
wiley   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source