Results 51 to 60 of about 14,776 (215)

Cucurbitacin-B Exerts Anticancer Effects through Instigation of Apoptosis and Cell Cycle Arrest within Human Prostate Cancer PC3 Cells via Downregulating JAK/STAT Signaling Cascade

Pharmaceuticals, 2022
Cucurbitacin-B (Cur-B) is an analogue triterpenoid belonging to the Cucurbitaceae family. Previous reports have explicitly outlined various biological activities of Cucurbitaceae family members, including the anticancer activity of Cur-B.
Ahmed Alafnan, Abdulwahab Alamri, Talib Hussain, Syed Mohd Danish Rizvi   +3 more
doaj   +1 more source

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

The cytotoxic Activity of Cucurbitacin E and Busulphan on ovarian and stomach cancer cells in vitro : a comparative study [PDF]

, 1996
A comparative study of the cytotoxicity of cucurbitacin E, a natural product, and busulphan on human ovarian and stomach cell lines was carried out.
Attard, Everaldo, Cuschieri, Alfred, Grixti, Mario, Scicluna-Spiteri, Anthony   +3 more
core  

Sensitivity of Meloidogyne incognita second-stage juvenile hatch, motility and viability to pure cucurbitacins and cucurbitacin-containing phytonematicides

South African Journal of Plant and Soil, 2018
Previous claims suggested that pure active ingredients from botanicals were less effective in pest management than their fermented crude-extracts.
Dube, Z.P., Mashela, P.W., de Waele, D.
openaire   +3 more sources

Confirmation of bioactivities of active ingredients of nemarioc-AL and nemafric-BL phytonematicides

Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2017
Nemarioc-AL and Nemafric-BL phytonematicides consistently reduced populations of plant-parasitic nematodes. The contribution of juvenile hatch inhibition to the overall reduction of the nematode numbers by the two phytonematicides, with cucurbitacin A ...
Z. P. Dube, P.W. Mashela
doaj   +1 more source

HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy

Pharmaceutics, 2021
The study describes the synthesis, physicochemical properties, and biological evaluation of polymer therapeutics based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers intended for a tumor-targeted immuno-oncotherapy.
Marina R. Tavares, Klára Hrabánková, Rafał Konefał, Martin Kaňa, Blanka Říhová, Tomáš Etrych, Milada Šírová, Petr Chytil   +7 more
doaj   +1 more source

Development of an Artificial Liquid Diet for Allelochemical Delivery in Lycorma delicatula

Journal of Applied Entomology, EarlyView.
ABSTRACT Spotted lanternfly, Lycorma delicatula White (Hemiptera: Fulgoridae), is an invasive phloem‐feeding planthopper native to Asia, which poses a growing threat to US agriculture due to its broad host range and rapid spread since its 2014 detection. To better understand how L.
Brian F. Ruether, Mariana Gelambi, Kate A. Burgiss, Alejandra Caballero, Sherry B. Hildreth, Dorothea Tholl   +5 more
wiley   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Induction of AHR Gene Expression in Colorectal Cancer Cell Lines by Cucurbitacin D, E, and I [PDF]

Journal of Cell and Molecular Research, 2019
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and its induction may result in suppressing of cell proliferation in colorectal cancer (CRC).
Younes Aftabi, Habib Zarredar, Mohammadreza Sheikhi, Zahra Khoshkam, Abasalt Hosseinzadeh Colagar   +4 more
doaj   +1 more source

Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus naudinianus

Biomolecules, 2023
The vast pool of structurally and functionally distinct secondary metabolites (i.e., natural products (NPs)) is constantly being expanded, a process also driven by the rapid progress in the development of analytical techniques. Such NPs often show potent
Moritz Benka, Kristof Görlitz, Michael C. Schöttgen, Simon Lagies, Daniel A. Mohl, Michel Kather, Iwanette Du Preez-Bruwer, Davis Mumbengegwi, Robin Teufel, Stefanie Kowarschik, Roman Huber, Dietmar A. Plattner, Bernd Kammerer   +12 more
doaj   +1 more source