Results 41 to 50 of about 448,910 (231)

Cue reactivity in nicotine and alcohol addiction: a cross-cultural view

Frontiers in Psychology, 2016
A wealth of research indicates that cue reactivity is critical to understanding the neurobiology of nicotine and alcohol addiction and developing treatments.
Wanwan Lv, Qichao Wu, Xiaoming Liu, Ying Chen, Hongwen Song, Li-Zhuang Yang, Xiaochu Zhang   +6 more
doaj   +1 more source

The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers

Brain and Behavior, 2021
Introduction The cannabinoid CB1 receptor (CB1R) has been shown in preclinical studies to be involved in nicotine reinforcement and relapse‐like behavior. The common single nucleotide polymorphism (SNP) rs2023239 may code for an alternative CB1R protein,
Chidera C. Chukwueke, William J. Kowalczyk, Marie Gendy, Richard Taylor, Rachel F. Tyndale, Bernard Le Foll, Stephen J. Heishman   +6 more
doaj   +1 more source

Traumatic Experiences and Reduced Alcohol Self-efficacy in Alcohol Dependent Inpatients: Attentional and Autonomic Mediators

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Self-medication with alcohol has been documented among individuals exposed to chronic trauma who may be unable to resist urges to drink in high-risk situations.
Eric L. Garland, Samantha Brown Brown, Matthew O. Howard   +2 more
doaj   +1 more source

Interaction between dysfunctional connectivity at rest and heroin cues-induced brain responses in male abstinent heroin-dependent individuals. [PDF]

PLoS ONE, 2011
BACKGROUND: The majority of previous heroin cue-reactivity functional magnetic resonance imaging (fMRI) studies focused on local function impairments, such as inhibitory control, decision-making and stress regulation.
Jixin Liu, Wei Qin, Kai Yuan, Jing Li, Wei Wang, Qiang Li, Yarong Wang, Jinbo Sun, Karen M von Deneen, Yijun Liu, Jie Tian   +10 more
doaj   +1 more source

Obesity and Dietary Added Sugar Interact to Affect Postprandial GLP-1 and Its Relationship to Striatal Responses to Food Cues and Feeding Behavior

Frontiers in Endocrinology, 2021
It has been hypothesized that the incretin hormone, glucagon-like peptide-1 (GLP-1), decreases overeating by influencing mesolimbic brain regions that process food-cues, including the dorsal striatum. We previously showed that habitual added sugar intake
Sabrina Jones, Sabrina Jones, Shan Luo, Shan Luo, Shan Luo, Hilary M. Dorton, Hilary M. Dorton, Alexandra G. Yunker, Alexandra G. Yunker, Brendan Angelo, Brendan Angelo, Alexis Defendis, Alexis Defendis, John R. Monterosso, John R. Monterosso, Kathleen A. Page, Kathleen A. Page, Kathleen A. Page   +17 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Individual differences in food-cue reactivity [PDF]

, 2007
Previous studies have suggested that brief exposure to the sight and smell of food can elicit a momentary increase in desire to eat that food and can stimulate food intake. This thesis sought to explore individual differences in this 'food-cue reactivity.
Amanda Tetley (7237100)
core   +5 more sources

Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers

Addiction Neuroscience, 2023
Craving reflects the subjective urge to use drugs and can be triggered by both positive and negative emotional states. No studies have systematically investigated the relative roles of these mechanisms in the pathophysiology of substance misuse. Here, we
Yu Chen, Chiang-Shan R. Li
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder

Frontiers in Psychiatry
BackgroundIndividuals with cocaine use disorder experience heightened motivation to pursue rewards tied to cocaine, often triggered by associated cues.
Etna J. E. Engeli, Katrin H. Preller, Nathalie M. Rieser, Nathalie M. Rieser, Johanna Klar, Johanna Klar, Philipp Staempfli, Lea M. Hulka, Matthias Kirschner, Matthias Kirschner, Erich Seifritz, Erich Seifritz, Marcus Herdener   +12 more
doaj   +1 more source