Results 71 to 80 of about 733,435 (263)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Los Juegos Olímpicos de Asterix y de los Pitufos: una nueva visión del deporte transmitida a la juventud = The Olympic Games celebrated by Bibi Fricotin, Les Pieds Nickelés, Astérix and the Smurfs

Materiales para la Historia del Deporte, 2015
francesa. Con el fin de revelar las representaciones de juegos en este tipo de literatura infantil, este estudio analizará los "Juegos Olímpicos", serie de cuatro álbumes (Bibi Fricotin, Les Pieds Nickelés, Astérix y los Pitufos), que tuvieron mucho ...
Christian Vivier, Sébastien Laffage-Cosnier, Michel Thiébaut   +2 more
doaj  

Promoting conservation culture through exchange in training on traditional and contemporary lining methods

CeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2019
Conservation training is much influenced by the culture context in which it is developed. Depending on the country of origin, structural treatment of canvas paintings widely varies, reflecting climate conditions but also training traditions.
Maria Aguiar, Nico Broers, Olivier Verheyden, Antonio Iaccarino Idelson, Paolo Roma, Ana Cudell   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effect of Pre-Incubation of Electrospun Silk Fibroin Scaffold in Complete and Serum-Free Media on Survival and Proliferation of Rat Bone Marrow Mesenchymal Stem Cells

Medical Laboratory Journal, 2022
Background and objectives: Developing scaffolds is important for tissue engineering and repairing damaged tissues. The present study aimed to investigate effects of pre-incubation of an electrospun silk fibroin scaffold in complete and serum-free media ...
Maryam Janitermi, esmail fattahi, seyed Gholam ali Jorsaraei   +2 more
doaj