Results 91 to 100 of about 965,886 (297)

Applying a cumulative risk framework to drinking water assessment: a commentary

open access: yesEnvironmental Health, 2019
The health risks of drinking water contaminants and the economic benefits of drinking water standards are typically assessed one chemical at a time, an approach that misses the health impacts of co-occurring contaminants in drinking water. In contrast, a
Tasha Stoiber   +4 more
doaj   +1 more source

A shapley value approach to pricing climate risks [PDF]

open access: yes, 2011
This paper prices the risk of climate change by calculating a lower bound for the price of a virtual insurance policy against climate risks associated with the business as usual (BAU) emissions path. In analogy with ordinary insurance pricing, this price
Cooke, Roger M
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Biased Risk Perceptions of Longevity and Disability in Old Age [PDF]

open access: yes
Rational learning theories postulate that information channels and cognitive biases such as individual optimism may influence an individuals assessment of the risk of undesired events, especially with regard to those that have a cumulative nature.
Joan Costa Font
core   +1 more source

How does the WFD address cumulative stress (including mixture toxicity) of pollutants to achieve good chemiscal and ecological status of water bodies? [PDF]

open access: yes, 2011
It is now more than ten years ago that the Water Framework Directive (WFD) was adopted by the European Parliament. The main objectives of the WFD are (i) to achieve good ecological and chemical status for inland surface waters, transitional waters and ...
Brock, T.C.M.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reliability and risk assessment of structures [PDF]

open access: yes
Development of reliability and risk assessment of structural components and structures is a major activity at Lewis Research Center. It consists of five program elements: (1) probabilistic loads; (2) probabilistic finite element analysis; (3 ...
Chamis, C. C.
core   +1 more source

Childhood Psychosocial Determinants of Cardiovascular Health [PDF]

open access: yes, 2016
Understanding risk and protective factors that impact cardiovascular health is of utmost importance. There is ample evidence that cardiovascular health begins in childhood, tracks over time, and is subject to adverse social influences. This paper reviews
Gidding, Samuel S., Sood, Erica D.
core   +2 more sources

Operationalizing risk-based cumulative effect assessments in the marine environment

open access: yesScience of The Total Environment, 2020
Ecosystem-based management requires an assessment of the cumulative effects of human pressures and environmental change. The operationalization and integration of cumulative effects assessments (CEA) into decision-making processes often lacks a comprehensive and transparent framework. A risk-based CEA framework that divides a CEA in risk identification,
Stelzenmüller, Vanessa   +17 more
openaire   +8 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy