Results 101 to 110 of about 9,893 (241)
What Does Iron Mean to an Oligodendrocyte?
Glia, Volume 73, Issue 9, Page 1784-1804, September 2025.Main Points Iron is essential for oligodendrocyte (OL) biology and myelin production, with deficiencies leading to severe neurological impairments. Understanding iron trafficking in OLs is crucial for developing treatments for dysmyelinating conditions. ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions.
Quinn W. Wade, James R. Connor
wiley +1 more source
P2x7 receptors control demyelination and inflammation in the cuprizone model
Brain, Behavior, & Immunity - Health, 2020 The contribution of P2x7 receptors to multiple sclerosis remains controversial, as both detrimental and beneficial effects resulting from P2x7 receptor loss-of-function have been reported in autoimmune models of the disease.
Ana Bernal-Chico +5 more
doaj +1 more source
Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions [PDF]
, 2007 The unambiguous identification of oligodendrocytes in tissue sections, especially in myelinated tracts, is often difficult. Most of the antibodies used to identify oligodendrocytes label the myelin sheath as well.
Brück, Wolfgang +4 more
core +1 more source
MedComm, Volume 6, Issue 9, September 2025.Therapies for neurodegenerative diseases (NDs) are constrained by the blood–brain barrier (BBB), which limits drug delivery. Exosomes, with their ability to cross BBB and deliver drugs efficiently, emerge as a promising platform for central nervous system‐targeted therapies. ABSTRACT Neurodegenerative diseases present significant therapeutic challenges,
Min Sun +6 more
wiley +1 more source
Astrogliosis During Acute and Chronic Cuprizone Demyelination and Implications for Remyelination
ASN Neuro, 2012 In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination.
Norah Hibbits +3 more
doaj +1 more source
Folia Neuropathologica, 2017 The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system.
Mohammadreza Semnani +3 more
doaj +1 more source
Diffusion basis spectrum imaging for identifying pathologies in MS subtypes [PDF]
, 2019 Diffusion basis spectrum imaging (DBSI) combines discrete anisotropic diffusion tensors and the spectrum of isotropic diffusion tensors to model the underlying multiple sclerosis (MS) pathologies. We used clinical MS subtypes as a surrogate of underlying
Cross, Anne H +8 more
core +2 more sources
CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.Proanthocyanidin B2 alleviates cuprizone‐induced demyelination in mice by modulating the astrocytic xCT/GSH/GPX4 axis, reducing inflammation and oxidative stress, and protecting oligodendrocytes, offering a novel therapeutic strategy for multiple sclerosis.
Jian Liu +10 more
wiley +1 more source
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis [PDF]
, 2021 Eystein Oveland +9 more
openalex +1 more source
Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination [PDF]
, 2019 Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS).
Ciric, Bogoljub +7 more
core +1 more source