The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry. [PDF]
ChemMedChem, 2018 AbstractThe Curtius rearrangement is the thermal decomposition of an acyl azide derived from carboxylic acid to produce an isocyanate as the initial product. The isocyanate can undergo further reactions to provide amines and their derivatives. Due to its tolerance for a large variety of functional groups and complete retention of stereochemistry during
Ghosh AK, Brindisi M, Sarkar A.
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The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses. [PDF]
Org Biomol Chem, 2018 An extensive review on the Curtius reaction and its recent applications in the synthesis of bioactive natural products are reported.
Ghosh AK, Sarkar A, Brindisi M.
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Stereospecificity of the Curtius rearrangement [PDF]
Canadian Journal of Chemistry, 1968 Jones and Mason claimed a number of years ago (1) that rearrangement of cis-olefinic acyl azides gave trans-olefinic isocyanates. However, several other workers have found that rearrangement of an acyl azide group attached to an optically active carbon gives configurationally identical products, a discovery which apparently conflicts with Jones and ...
Martin B. Hocking
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Novel Inhibitors of Acetyl- and Butyrylcholinesterase Derived from Benzohydrazides: Synthesis, Evaluation and Docking Study [PDF]
Pharmaceuticals, 2023 On the basis of previous reports, novel 2-benzoylhydrazine-1-carboxamides were designed as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Inhibitors of these enzymes have many clinical applications.
Neto-Honorius Houngbedji +6 more
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N,N′-Dibenzylethylenediammonium dichloride [PDF]
Acta Crystallographica Section E: Crystallographic CommunicationsThe isolation and crystalline structure of N,N′-dibenzylethylenediammonium dichloride, C16H22N22+·2Cl−, is reported. This was obtained as an unintended product of an attempted Curtius rearrangement that involved benzylamine as one of the reagents and 1,2-
Mary Helene Marmande +3 more
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Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives [PDF]
Beilstein Journal of Organic Chemistry, 2021 A continuous flow process is presented that couples a Curtius rearrangement step with a biocatalytic impurity tagging strategy to produce a series of valuable Cbz-carbamate products.
Alexander Leslie +4 more
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Curtius rearrangement and Wolff homologation of functionalized peroxides
Tetrahedron Letters, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Patrick H. Dussault, Chunping Xu
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Curtius Rearrangement of Aromatic Carboxylic Acids to Access Protected Anilines and Aromatic Ureas. [PDF]
Organic Letters, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
H. Lebel, Olivier Leogane
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An efficient new method for the synthesis of 3-[18 F]fluoro-4-aminopyridine via Yamada-Curtius rearrangement. [PDF]
J Labelled Comp Radiopharm, 2018 Basuli F +4 more
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Boc-protected 1-(3-oxocycloalkyl)ureas via a one-step Curtius rearrangement: mechanism and scope. [PDF]
Tetrahedron Lett, 2014 Sun X +5 more
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